With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4842-86-8,Ethyl 3-piperidinecarboxylate hydrochloride,as a common compound, the synthetic route is as follows.
Example 12 5-[(3-Ethoxycarbonyl)piperidyl]-1-(3-ethoxy-4-methoxyphenyl)-1-penten-3-one hydrochloride Compound No. 12 0.387g (2.0mmol) of 3-ethoxycarbonylpiperidine hydrochloride and 0.4g (14mmol) of paraformaldehyde were dissolved in anhydrous ethanol (5ml). The pH value of the solution was adjusted to pH =2-3 with concentrated hydrochloric acid and the reaction mixture was refluxed and stirred for 2hr. After the solid was dissolved, 0.44g (2.0mmol) of 4-(3-ethoxy-4-methoxyphenyl)-3-buten-2-one (prepared as described in preparation 4) was added to the above reaction mixture. The solution was further refluxed and stirred for 11hr. TLC showed the reaction was completed, after staying overnight at room temperature, the precipitated solid was collected by filtration and then recrystallized from 95% ethanol and dried to give 0.26g of crystals, yield: 30.1 %, mp: 158-160C. 1H-NMR deltappm (DMSO-d6): 1.21(t, 3H, J=7.2 Hz, OCH2CH3), 1.33(t, 3H, J=7.2 Hz, COOCH2CH3), 2.26-2.71(brs, 5H, (CH2)2CH), 3.30-3.40(m, 8H, 3NCH2+COCH2), 3.80(s, 3H, OCH3), 4.10 (d, d, 4H, J=7.2 Hz, J=7.2 Hz, COOCH2CH3, OCH2CH3), 6.82(d, 1H, J=16.2Hz =CHCO), 7.02 (d, 1H, J=9.0Hz, ArH), 7.27(d, J=8.1Hz, 1H, ArH), 7.32(s, 1H, ArH), 7.63(d, 1H, J=16.2Hz, CH=). MS (m/z): 389(M+, 15), 344(M+-45, 12), 232(M+-156+H, 45), 316(M+-73, 3).
4842-86-8, 4842-86-8 Ethyl 3-piperidinecarboxylate hydrochloride 12896004, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES; EP1783115; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem