479630-08-5 | Page 2 of 2 | Heterocyclic Building Blocks-piperidine

Brief introduction of 479630-08-5

479630-08-5, The synthetic route of 479630-08-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479630-08-5,1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine,as a common compound, the synthetic route is as follows.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l-carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 6-fluoro- lH-indazol-3-ylamine (337 mg, 2.27 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in l-methoxy-2-propanol (11 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4: 1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4: 1) and evaporated in vacuo. The residue was triturated with 4 mL MTBE/ethyl acetate (1 : 1), filterered, washed with ethyl acetate (2 mL) and dried for 16 h at 50C in vacuo to yield the title compound (66 mg, 7% of theory) as colorless solid. LC-MS (Method IB): Rt = 1.01 min, MS (ESIPos): m z = 387 [M+H]+

479630-08-5, The synthetic route of 479630-08-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HASSFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; CANCHO-GRANDE, Yolanda; BEYER, Kristin; ROeHRIG, Susanne; KOeLLNBERGER, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; WO2015/67549; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

Simple exploration of 479630-08-5

479630-08-5, 479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various fields.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l-carboxylate (1.07 g, 3.58 mmol, 1.5 eq), 4-ethoxy- lH-indazol-3-amine (423 mg, 2.39 mmol, 1 eq) and potassium phosphate (1.01 g, 4.78 mmol, 2 eq) were suspended in l-methoxy-2-propanol (10 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4: 1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4: 1) and evaporated in vacuo. The residue was triturated with MTBE (15 mL), filterered, washed with MTBE (2 mL) and dried for 16 h at 50C in vacuo to yield the title compound (161 mg, 15% of theory). LC-MS (Method IB): Rt = 1.11 min, MS (ESIPos): m z = 413 [M+H]+

479630-08-5, 479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various fields.

New learning discoveries about 479630-08-5

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

479630-08-5, 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 5 (15 g, 45 mmol) was dissolved in anhydrous ethanol (400 mL) with compound 6 (9.45 g, 49.5 mmol), followed by addition of trifluoroacetic acid (20 mL) and heating at 80 C for 12 hours. Cool to room temperature and spin the solvent. The reaction mixture was diluted with water (100 mL), extracted with 1 M NaOH, and extracted with ethyl acetate (3×200 mL). The extract was dried over anhydrous sodium sulfate, filtered and dried with methanol: dichloromethane = 1:20 Compound 7 (13. 82 g, 72%) was isolated.

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

Reference£º
Patent; HU, XIANMING; HONG, XUECHUAN; WANG, HONGBO; ZHU, XI; DING, MINGMIN; L, GUANGYAO; ZHANG, JIANQIAO; WEN, MENG; QU, CHUNRONG; ZHU, JINMEI; (14 pag.)CN104292233; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

Simple exploration of 479630-08-5

479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various.

Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-l -carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 4- (trifluoromethyl)-lH-indazol-3-amine (448 mg, 2.27 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in l-methoxy-2-propanol (11.8 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180C for 15 min. After cooling to RT, the suspension was diluted with water (20 mL) and neutralized (pH 5) by the addition of IN HCl and extracted with ethyl acetate (2x 30 mL). The combined organic phases were washed with brine (10 mL), dried over sodium sulfate, filtered and evaporated in vacuo. The brown residue was purified by preparative HPLC (Method 1A). The combined product fractions were evaporated in vacuo to remove acetonitrile. The resulting suspension was filtered, the residue was washed with water (2 ml) and dried for 16 h at 50C in vacuo to yield the title compound (116 mg, 12% of theory) as colorless solid. LC-MS (Method IB): Rt = 1.19 min, MS (ESIPos): m/z = 437 [M+H]+

479630-08-5 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine 6618868, apiperidines compound, is more and more widely used in various.