Category: 477600-70-7

Chemistry is traditionally divided into organic and inorganic chemistry. Safety of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 477600-70-7

The invention provides compounds of formula 1: ( I ) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for suppressing an immune response or treating cancer or a hematologic malignancy using compounds of formula I.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine, you can also check out more blogs about477600-70-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H17686N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 477600-70-7, Name is (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine, molecular formula is C14H22N2. In a Patent, authors is ，once mentioned of 477600-70-7

Disclosed are compounds according to Formula (I), and related pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 477600-70-7, help many people in the next few years.Application In Synthesis of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

Reference：
Piperidine – Wikipedia,
Piperidine | C5H17694N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 477600-70-7

Discovery of CP-690,550: A potent and selective janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection

There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells and are involved in the signaling of multiple cytokines important for various T cell functions. Blockade of the JAK1/JAK3-STAT pathway with a small molecule was anticipated to provide therapeutic immunosuppression/immunomodulation. The Pfizer compound library was screened against the catalytic domain of JAK3 resulting in the identification of a pyrrolopyrimidine-based series of inhibitors represented by CP-352,664 (2a). Synthetic analogues of 2a were screened against the JAK enzymes and evaluated in an IL-2 induced T cell blast proliferation assay. Select compounds were evaluated in rodent efficacy models of allograft rejection and destructive inflammatory arthritis. Optimization within this chemical series led to identification of CP-690,550 1, a potential first-in-class JAK inhibitor for treatment of autoimmune diseases and organ transplant rejection.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine, you can also check out more blogs about477600-70-7

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17682N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. 477600-70-7. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 477600-70-7

Chiral piperidine compound of preparation method and chiral resolving agent recovery mechanically method (by machine translation)

The invention discloses a chiral piperidine compound of preparation method and chiral resolving agent of the recycled method, the invention takes the 1 – benzyl – 4 – methyl – 3 – piperidine alcohol as the starting material, halo, armor amination, chiral separation of reaction such as preparation into (3 R, 4 R) – N, 4 – dimethyl – 1 – (phenyl methyl) – 3 – amino piperdine double-hydrochloric acid salt product, at the same time will split the stock solution of alkali treatment, in accordance with the refined after the purification of the recovered response requires the ((2 R, 3 R) – 2, 3 – double-[(4 – methyl benzoyl) oxy] succinic acid product. The invention has the beneficial effect that: 1, short synthetic route, all intermediate purity is easy to control, beneficial control of impurity content; 2, each step reaction process simple and convenient operation, and at the same time a large amount of chiral resolving agent can be recycled, the production cost is reduced at the same time reduce the amount of the solid waste, and is suitable for large-scale industrial production. (by machine translation)

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 477600-70-7 is helpful to your research. 477600-70-7

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17690N – PubChem

 

477600-70-7, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4,6-dichloro-5-methoxy-pyrimidine (0.66g, 3.68mmol) and (3R, 4R) -1- benzyl -N, 4- dimethyl-piperidin-3-amine (0.80g, 3.68 mmol) was dissolved in DMF (5mL), was added potassium carbonate (1.02g, 7.36mmol), 70 reaction was stirred overnight under nitrogen.Water was added (100 mL) to quench the reaction, extracted with ethyl acetate (80mL ¡Á 3), the organic phase was washed with water (50 mL) washed with saturated aqueous sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure, subjected to column chromatography (eluent: PE / EtOAc (v / v) = 1/1), to give the product 1.13g, yield: 85.0%.

477600-70-7, 477600-70-7 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 44630604, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Huang, Jiuzhong; Ren, Xingye; Li, Zhi; Zhang, Yingjun; Zhang, Changchun; (55 pag.)CN105566321; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem