Category: 476014-76-3

Chemistry is an experimental science, Recommanded Product: 476014-76-3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 476014-76-3, Name is 4-Hydroxy-2-piperidinone

The present invention provides novel substituted cyclic compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 476014-76-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 476014-76-3, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H2235N – PubChem

476014-76-3, 4-Hydroxy-2-piperidinone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,476014-76-3

[0242] (6) 4-hydroxypiperidin-2-one (0.80g, 6.94mmol) was dissolved in DMF. DMAP (0.085g, 0.694mmol) and imidazole(0.92g, 13.88mmol) were added. After the resulting mixture was stirred evenly, the solution of TBDPS-Cl (2.3g,8.33mmol) in THF was added and stirred at room temperature overnight. After the reaction completed, the reactionmixture was dried by spinning. Column chromatography afforded colorless oily liquid 0.65g, yield 60percent.[0243] 1H NMR (300 MHz, CDCl3) delta 7.70-7.49 (m, 4H), 7.53-7.30 (m, 6H), 4.24-4.09 (dt, J = 8.9,3.0 Hz, 1H),3.62-3.49(dt, J = 13.0, 6.7 Hz, 1H),3.20-3.08 (dtd, J = 11.7, 5.6, 2.3 Hz, 1H), 2.51-2.35 (d, J = 4.8 Hz, 2H),1.83-1.69(m,2H),1.17-1.00 (s,9H).MS(ESI) m/z :[(M+1)+,158.3]

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Reference£º
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Zhe Jiang Jutai Pharmaceutical Co., Ltd; YANG, Yushe; XUE, Tao; DING, Shi; GUO, Bin; EP2947085; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem