Awesome Chemistry Experiments For (S)-3-Hydroxypiperidine hydrochloride

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An asymmetric synthesis of substituted piperidines has been described. beta-Cyclodextrin- or oxazaborolidine-catalyzed asymmetric reduction of alpha-azido aryl ketones to the corresponding alcohols has been employed as the key step along with ring closing metathesis and selective dihydroxylation.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H6353N – PubChem

 

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The present invention relates to substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators. Depending on the structure and the stereochemistry the compounds of the invention are either selective agonists or selective antagonists of the human melanocortin-4 receptor (MC-4R). The agonists can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. Generally all diseases and disorders where the regulation of the MC-4R is involved can be treated with the compounds of the invention.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H6331N – PubChem

 

Can You Really Do Chemisty Experiments About (S)-3-Hydroxypiperidine hydrochloride

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: piperidines, you can also check out more blogs about475058-41-4

Chemistry is traditionally divided into organic and inorganic chemistry. category: piperidines. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 475058-41-4

Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H6349N – PubChem

 

Awesome Chemistry Experiments For (S)-3-Hydroxypiperidine hydrochloride

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Reference of 475058-41-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 475058-41-4, Name is (S)-3-Hydroxypiperidine hydrochloride, molecular formula is C5H12ClNO. In a Patent,once mentioned of 475058-41-4

The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X1, X2, X3, R1, R3, ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H6339N – PubChem

 

Awesome Chemistry Experiments For 475058-41-4

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SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS

The present invention provides fused aryl and heteroaryl derivatives of Formula I that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6337N – PubChem

 

Archives for Chemistry Experiments of (S)-3-Hydroxypiperidine hydrochloride

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Method for industrial production of (S)-3-(4- n)-bromophenyl-piperidine (by machine translation)

The invention belongs to the field of chemical, medicine synthesis, and provides a method (S)- 3 – (4 – for) producing a C; five.membered B; cyclic (S)- 1 – sulfonic acid (S)- 3 – ester compound, through a tert-butyloxycarbonyl, protecting group as an initial raw material. A; A B C, (S)- 3 – (4 -). (by machine translation)

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Piperidine – Wikipedia,
Piperidine | C5H6343N – PubChem

 

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 475058-41-4, molcular formula is C5H12ClNO, introducing its new discovery. Safety of (S)-3-Hydroxypiperidine hydrochloride

SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H6344N – PubChem

 

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475058-41-4, Big data shows that 475058-41-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.475058-41-4,(S)-3-Hydroxypiperidine hydrochloride,as a common compound, the synthetic route is as follows.

(A) N8-[4-(tert-Butyl)-1,3-thiazol-2-yl]-2-[(3S)-3-hydroxyhexahydro-1-pyridinyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxamide Reactions were performed in the same manner as in Example 8, (E) by using N8-[4-(tert-butyl)-1,3-thiazol-2-yl]-2,4-dioxo-3,4-dihydro-2H-pyrido[1,2-a]pyrimidine-8-carboxamide (600 mg, 1.74 mmol) and (S)-(-)-3-hydroxypiperidine hydrochloride (360 mg, 2.61 mmol) to obtain 463 mg (62%) of the title compound. 1H-NMR (CDCl3) delta: 1.35 (9H, s), 1.59 (1H, brd), 1.73-1.99 (3H, m), 3.61 (3H, m), 3.93 (2H, m), 5.71 (1H, s), 6.61 (1H, s), 7.31 (1H, d, J=7.32 Hz), 7.77 (1H, s), 8.89 (1H, d, J=7.32 Hz) EI/MS; m/s: 428 (M++1)

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Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD; US2003/92720; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem