Category: 4727-72-4

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Wu Yali, once mentioned the application of 4727-72-4, Name is 1-Benzylpiperidin-4-ol, molecular formula is C12H17NO, molecular weight is 191.2695, MDL number is MFCD00006503, category is piperidines. Now introduce a scientific discovery about this category, Computed Properties of C12H17NO.

Recent Progress in Applications of Vinylaziridines in Organic Synthesis

Due to its alkene moiety and highly strained aziridine scaffold, vinylaziridines represent a versatile type of synthetic building blocks and can undergo various chemcial transformations. These transformations enabled facile synthesis of a wide range of nitrogen-containing compounds, especially diverse nitrogen heterocycles, inculding azetidines, pyrrolidines, piperidines, azacycloheptanes and so on. Moreover, development of simple and efficient synthetic methods for various substituted vinylaziridines, stimulating their applications in the fields of organic synthesis, medicinal and agrochemistry, as well as fine chemistry. In recent years, such type of reagents continue to attract considerable research efforts from chemists and enjoyed rapid development. The representative examples of nucleophilic ring-opening and cyclization reactions of vinylaziridines over the past five years are summarized. Moreover, the prospects of further development are also disscussed.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 4727-72-4, Name is 1-Benzylpiperidin-4-ol, molecular formula is , belongs to piperidines compound. In a document, author is Ngemenya, Moses N., Computed Properties of C12H17NO.

Structurally simple synthetic 1,4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

Background: Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1,4-disubstituted piperidines with simple molecular structures were evaluated in this study. Methods: Antiplasmodial activity were determined against cultured chloroquine-sensitive 3D7 and resistant Dd2 strains of P. falciparum by in vitro parasite growth inhibition. A primary screen was done to identify active compounds by fluorescence microscopy followed by a secondary screen to determine IC50 and IC90 values of active compounds by the parasite lactate dehydrogenase assay. Cytotoxicity of active compounds was assessed using the MTT/formazan assay and selectivity indices (SIs) determined. Optical densities were analysed to obtain experimental results. Results: The compounds produced 56 to 93% inhibition of parasite growth at 40 mu g/mL. Eight compounds (2 ketone, 5 alcohol and one amine analogues) showed high activity (IC(50)s between 1 and 5 mu g/mL). Nine compounds were highly selective for the parasite (SIs = 15 to 182). Three promising (alcohol) analogues were identified: [1-(4-fluorobenzyl) piperidin- 4-yl] [4-fluorophenyl] methanol, (7), [1-(3, 4-dichlorobenzyl) piperidin-4-yl] [4- fluorophenyl] methanol (8) and [1-(4-bromobenzyl) piperidin-4-yl] [4- fluorophenyl] methanol (11) which were more active on the resistant strain (IC50 values between 1.03 to 2.52 mu g/mL), than the sensitive strain (IC50 values between 2.51 to 4. 43 mu g/mL). Conclusions: The alcohol analogues were the most active and most selective for the parasite with three promising hit molecules identified among them, suggesting the hydroxyl group at C-7′ in these alcohol analogues is contributing greatly to their antiplasmodial activity. Further exploration of the core structure using chemistry approaches and biological screening including in vivo studies in an animal model of malaria may yield important antimalarial leads.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4727-72-4, in my other articles. Computed Properties of C12H17NO.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 4727-72-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4727-72-4, name is 1-Benzylpiperidin-4-ol. In an article£¬Which mentioned a new discovery about 4727-72-4

BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS

Provided are novel compounds having an inhibitory activity against production or secretion of beta-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.4727-72-4. In my other articles, you can also check out more blogs about 4727-72-4

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H12689N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ name: 1-Benzylpiperidin-4-ol, Which mentioned a new discovery about 4727-72-4

COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

The present invention relates to compounds acting both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists, to processes for their preparation, to compositions comprising them, to therapeutic uses and combinations with other pharmaceutical active ingredients.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, name: 1-Benzylpiperidin-4-ol, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4727-72-4

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H12640N – PubChem