Category: 41556-26-7

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 41556-26-7

Provided are a pressure-sensitive adhesive composition, a protective film, an optical device, and a display device. The pressure-sensitive adhesive composition may exhibit excellent storage stability, suitable low speed and high speed peel-off strengths after forming a crosslinking structure, and have an excellent balance between them. Accordingly, the pressure-sensitive adhesive composition may exhibit an excellent protective effect when applied to a protective film, may be easily peeled in a high speed peel-off and thus advantageous for a high speed process, and may exhibit an excellent antistatic characteristic.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, you can also check out more blogs about41556-26-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24173N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, Which mentioned a new discovery about 41556-26-7

The present invention relates to an ultraviolet absorber for synthetic resins composed of a triazine compound represented by the general formula (I) shown below (wherein R represents an alkyl group having 1 to 4 carbon atoms, n is 0 or an integer of up to 2, and X represents a group selected from the consisting of group (a) to (d) shown below) (wherein R1 represents an aliphatic group having 5 to 60 carbon atoms, which is an alicyclic group, an alkyl group having an alicyclic group at the terminal or in the chain thereof, an alkyl group having a branch, or a linear alkyl group, depending on the number of carbon atoms; R2 represents an alkyl group having 1 to 18 carbon atoms or a (poly)alkyleneoxyalkyl group; R’ represents an aliphatic diyl group having 5 to 60 carbon atoms; R and n have the same meanings as those described in the general formula (I) above).

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 41556-26-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24162N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 41556-26-7

A composition is provided comprising a high viscosity amino functional silicone fluid, a silicone glycol copolymer, an aqueous-based intumescent flame retardant, and an aqueous-based concentrated cationic fluoropolymer system that cures at ambient temperatures. The composition is characterized by providing a protective coating and enhancing the appearance of a wide variety of porous and non-porous vehicle interior material surfaces, including rubber, vinyl, fabric, carpeting, metal, metal alloys, chrome, leather, carbon fiber, aluminum, different grains of wood, dashboard tech screens, plastic made from renewable sources, and plastic made from non-renewable sources.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, you can also check out more blogs about41556-26-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H24204N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4. In an article, author is Zampieri, Daniele,once mentioned of 41556-26-7, SDS of cas: 41556-26-7.

New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation

The sigma receptor (sigma R) family has been considered mysterious for a long time. In fact, the sigma 2R subtype has been cloned only recently, revealing its identity as TMEM97, a NPC1-binding protein involved in cholesterol biosynthesis and implicated in the pathogenesis of cancer and neurologic disorders. With the aim of developing new chemical entities gifted with sigma R affinity, herein we report the design and synthesis of new piperidine-based alkylacetamide derivatives with mixed affinity towards both sigma 1 and sigma 2R subtypes.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Huang, Huoming, once mentioned the application of 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4, molecular weight is 508.78, MDL number is MFCD00134706, category is piperidines. Now introduce a scientific discovery about this category, Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate.

Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic

Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been dedicated to reduce undesirable side effects, moderate progress has been made. In this work, starting from Tramadol, a series of 3-((dimethylamino)methyl)-4hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxamide derivatives were designed and synthesized, and their in vitro and in vivo activities were evaluated. Our campaign afforded selective opioid receptor (MOR) ligand 2a (K-i (MOR): 7.3 +/- 0.5 nM; K-iDOR: 849.4 +/- 96.6 nM; K-i KOR: 49.1 +/- 6.9 nM) as potent analgesic with ED50 of 3.1 mg/kg in 55 degrees C hot plate model. Its antinociception effect was blocked by opioid antagonist naloxone. High binding affinity toward MOR of compound 2a was associated with water bridge, salt bridge, hydrogen bond and hydrophobic interaction with MOR. The high selectivity of compound 2a for MOR over delta opioid receptor (DOR) and kappa opioid receptor (KOR) was due to steric hindrance of compound 2a with DOR and KOR. 2a, a compound with novel scaffold, could serve as a lead for the development of novel opioid ligands. (C) 2020 Elsevier Masson SAS. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 41556-26-7, Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 41556-26-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, SMILES is O=C(OC1CC(C)(C)N(C)C(C)(C)C1)CCCCCCCCC(OC2CC(C)(C)N(C)C(C)(C)C2)=O, belongs to piperidines compound. In a article, author is Ramalingam, Arulraj, introduce new discover of the category.

Synthesis, Crystal Structure, DFT Calculations and Hirshfeld Surface Analysis of 3-Chloro-2,6-Bis(4-Chlorophenyl)-3-Methylpiperidin-4-One

The 3-chloro-2,6-bis(4-chlorophenyl)-3-methylpiperidin-4-one (CCMP) compound have been characterized by FT-IR,H-1-NMR,C-13-NMR,H-1-H-1 NOESY spectroscopy and single-crystal X-ray diffraction. The title compound crystallizes in the orthorhombic space groupPna21. The single crystal measurements reveal a distorted chair conformation [puckering parameter Q = 0.557 (3) A degrees; theta = 167.8 (3)degrees and psi = 206.8 (13)degrees]. The optimized geometric parameters and frequency values were theoretically calculated using DFT/B3LYP method with B3LYP/6-31+G(d,p) basis set. The XRD single crystal measurement parameters are good agreed with the optimized parameters. The spectral and optimized parameters showed that the piperidine-4-one ring adopts normal chair conformation with equatorial orientations of all the substituents except chlorine. The frontier molecular orbitals HOMO and LUMO were computed to know the chemical reactivity and kinetic stability of the molecular compound. Hirshfeld surface analysis was also performed. Hirshfeld surface analysis (d(norm)surface, two-dimensional fingerprint plots and molecular electrostatic potantials) revealed the nature of intermolecular interactions. The most important contributions for the crystal packing are from H center dot center dot center dot H (35%), Cl center dot center dot center dot H/H center dot center dot center dot Cl (32.3%), C center dot center dot center dot H/H center dot center dot center dot C (15%) and O center dot center dot center dot H/H center dot center dot center dot O (7.5%) interactions. Graphic In this study, spectroscopic properties of a new piperidine-4-one crystal compound and it’s DFT structural investigation compared with experimental were gained to literature. [GRAPHICS] .

Electric Literature of 41556-26-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41556-26-7.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is , belongs to piperidines compound. In a document, author is Kiso, Tetsuo, Product Details of 41556-26-7.

ASP8477, a fatty acid amide hydrolase inhibitor, exerts analgesic effects in rat models of neuropathic and dysfunctional pain

Exogenous cannabinoid receptor agonists are clinically effective for treating chronic pain but frequently cause side effects in the central nervous system. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide, an endogenous cannabinoid agonist. 3-Pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477) is a potent and selective FAAH inhibitor that is orally active and able to increase the brain anandamide level and is effective in rat models of neuropathic and osteoarthritis pain without causing motor coordination deficits. In the present study, we examined the pharmacokinetics and pharmacodynamics, analgesic spectrum in pain models, and the anti-nociceptive mechanism of ASP8477. Single and four-week repeated oral administration of ASP8477 ameliorated mechanical allodynia in spinal nerve ligation rats with similar improvement rates. Further, single oral administration of ASP8477 improved thermal hyperalgesia and cold allodynia in chronic constriction nerve injury rats. ASP8477 also restored muscle pressure thresholds in reserpine-induced myalgia rats. This analgesic effect of ASP8477 persisted for at least 4 h, consistent with the inhibitory effect observed in an ex vivo study using rat brain as well as the increasing effect on oleoylethanolamide and palmitoylethanolamide levels but not the ASP8477 concentration in rat brain. ASP8477 also improved alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-, N-methyl-D-aspartic acid (NMDA)-, prostaglandin E-2-, prostaglandin F-2(alpha)-, and bicuculline-induced allodynia in mice, showing broader analgesic spectra than existing drugs. In contrast, however, ASP8477 did not affect acute pain. These results indicate that the FAAH inhibitor ASP8477 exerts analgesic effects on neuropathic and dysfunctional pain, and its pharmacological properties are suitable for use in treating chronic pain.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 41556-26-7, in my other articles. Product Details of 41556-26-7.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Kowalska, Alicja, once mentioned the application of 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4, molecular weight is 508.78, MDL number is MFCD00134706, category is piperidines. Now introduce a scientific discovery about this category, SDS of cas: 41556-26-7.

Synthesis and anticancer activity of multisubstituted purines and xanthines with one or two propynylthio and aminobutynylthio groups

A synthesis of new 2,6-disubstituted and 2,6,8-trisubstituted 7-methylpurines as well as 8-substituted 3,7-dimethylxanthines containing a triple bond chain have been worked out. Purinethiones and xanthinethiones were converted into propynylthio derivatives, which were then further transformed via a Mannich reaction into aminobutynylthio derivatives (amine = pyrrolidine, piperidine, morpholine, and diethylamine). The products thus obtained represent various types of the purine and xanthine structure: 8-mono-, 2,6- and 6,8-dipropynylthio, 6- and 8-monoaminobutynylthio, 2,6- and 6,8-diaminobutynylthio derivatives. All of these compounds were tested for their anticancer activity against human glioblastoma SNB-19, human adenocarcinoma MDA-MB-231, and melanoma C-32 cell lines. The anticancer activity depends on the nature of the substituent and its localization in the purine and xanthine framework. Generally, compounds possessing two alkynylthio groups (propynylthio or aminobutynylthio) were more active than those possessing only one group. Some compounds exhibited stronger or similar anticancer activity to cisplatin. All compounds were also tested for their cytotoxic activity against normal human fibroblasts (HFF-1). The most promising anticancer compounds were found to be 2,6-dipropynylthio-7-methylpurine 4, 2-chloro-6,8-dipropynylthio-7-methylpurine 14, and 2-chloro-6,8-di(N-morpholinylbutynylthio)-7-methylpurine 15c acting selectively on glioblastoma SNB-19, melanoma C-32, and adenocarcinoma MDA-MB-231 with the IC50 = 0.07-4.08 mu g/mL.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 41556-26-7, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, SMILES is O=C(OC1CC(C)(C)N(C)C(C)(C)C1)CCCCCCCCC(OC2CC(C)(C)N(C)C(C)(C)C2)=O, belongs to piperidines compound. In a article, author is Lazewska, Dorota, introduce new discover of the category.

Novel naphthyloxy derivatives – Potent histamine H-3 receptor ligands. Synthesis and pharmacological evaluation

A series of 1- and 2-naphthyloxy derivatives were synthesized and evaluated for histamine H-3 receptor affinity. Most compounds showed high affinities with K-i values below 100 nM. The most potent ligand, 1-(5-(naphthalen-1-yloxy) pentyl)azepane (11) displayed high affinity for the histamine H-3 receptor with a Ki value of 21.9 nM. The antagonist behaviour of 11 was confirmed both in vitro in the cAMP assay (IC50=312 nM) and in vivo in the rat dipsogenia model (ED50=3.68 nM). Moreover, compound 11 showed positive effects on scopolamine induced-memory deficits in mice (at doses of 10 and 15 mg/kg) and an analgesic effect in the formalin test in mice with ED50=30.6 mg/kg (early phase) and ED50=20.8 mg/kg (late phase). Another interesting compound, 1-(5-(Naphthalen-1-yloxy)pentyl)piperidine (13; H3R K-i=53.9 nM), was accepted for Anticonvulsant Screening Program at the National Institute of Neurological Disorders and Stroke/National Institute of Health (Rockville, USA). The screening was performed in the maximal electroshock seizure (MES), the subcutaneous pentylenetetrazole (scPTZ) and the 6-Hz psychomotor animal models of epilepsy. Neurologic deficit was evaluated by the rotarod test. Compound 13 inhibited convulsions induced by the MES with ED50 of 19.2 mg/kg (mice, i.p.), 17.8 (rats, i.p.), and 78.1 (rats, p.o.). Moreover, 13 displayed protection against the 6-Hz psychomotor seizures (32 mA) in mice (i.p.) with ED50 of 33.1 mg/kg and (44 mA) ED50 of 57.2 mg/kg. Furthermore, compounds 11 and 13 showed in vitro weak influence on viability of tested cell lines (normal HEK293, neuroblastoma IMR-32, hepatoma HEPG2), weak inhibition of CYP3A4 activity, and no mutagenicity. Thus, these compounds may be used as leads in a further search for histamine H3 receptor ligands with promising in vitro and in vivo activity. (C) 2018 Published by Elsevier Ltd.

Reference of 41556-26-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41556-26-7.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4, belongs to piperidines compound, is a common compound. In a patnet, author is Ji, Zhi-Xiang, once mentioned the new application about 41556-26-7, Formula: C30H56N2O4.

Crystal Structure and Catalytic Activity of A Novel Cd(II) Coordination Polymer Formed by Dicarboxylic Ligand

A new Cd(II) coordination polymer, {[Cd-3(L)(2)(DMF)(2)(H2O)(2)] H2O}n (H2L = 1,3-bisbenzyl-2imidazolidine- 4,5-dicarboxylic acid) was synthesized by one-pot synthesis method from 1,3-bisbenzyl-2imidazolidine- 4,5-dicarboxylic acid, NaOH, DMF, and Cd(NO3)(2) 4H(2)O. Its structure was determined by elemental analysis and single crystal X-ray diffraction. Structural analysis shows that three Cd(II) ions are all six-coordinated with four oxygen atoms of four 1,3-bisbenzyl-2-imidazolidine-4,5-dicarboxylate ligands and two O atoms from two DMF molecules (Cd1) or two oxygen atoms of two coordinated H2O molecules (Cd2 and Cd3) to form an octahedral coordination geometry. The Cd(II) coordination polymer displays a 1D chained structure by the bridging carboxylate groups from 1,3-bisbenzyl-2-imidazolidine4,5- dicarboxylate ligands. The conversion of benzaldehyde is 90.9%, which is 40 similar to 50% higher than those of the other three aldehydes (4-methylbenzaldehyde, p-methoxybenzaldehyde and 3chlorobenzaldehyde), so the Cd(II) coordination polymer catalyst shows better catalytic activity for the coupling reaction of benzaldehyde, phenylacetylene, and piperidine than the other three aldehydes. Copyright (C) 2018 BCREC Group. All rights reserved

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem