Category: 4045-22-1

McManus, J. M. et al. published their research in Journal of Medicinal Chemistry in 1965 | CAS: 4045-22-1

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Formula: C7H13NO2

Sulfamylurea hypoglycemic agents. I. Synthesis and screening was written by McManus, J. M.;McFarland, J. W.;Gerber, C. F.;McLamore, W. M.;Laubach, G. D.. And the article was included in Journal of Medicinal Chemistry in 1965.Formula: C7H13NO2 This article mentions the following:

A number of sulfamylureas of general structure R1R2NSO2NHCONHR have been prepared and screened for hypoglycemic activity in the rat. The more promising variations in the R1R2N portion of the mol. were those derived from heterocyclic amines, especially piperidines and morpholines. In these series, activity was maximal when R was cyclohexyl, cycloheptyl, or bicycloalkyl. Several analogs, notably certain 4,4-disubstituted piperidine derivatives, were comparable in hypoglycemic potency to chloropropamide. Structure-activity relationships are discussed, and a brief discussion is given of the use in synthetic planning of certain phys. and chem. parameters that appear to be important determinants of drug dynamics in this class of compounds In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1Formula: C7H13NO2).

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Formula: C7H13NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Regnier, Gilbert L. et al. published their research in European Journal of Medicinal Chemistry in 1987 | CAS: 4045-22-1

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C7H13NO2

New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity was written by Regnier, Gilbert L.;Guillonneau, Claude G.;Duhault, Jacques L.;Tisserand, Francoise P.;Saint-Romas, Guy;Holstorp, Sophie M.. And the article was included in European Journal of Medicinal Chemistry in 1987.Synthetic Route of C7H13NO2 This article mentions the following:

Twenty-nine new derivatives of 8-aminoalkyl-substituted xanthine [e.g. I, R1 = H, Me, Et; R2 = Me, iso-Pr, Ph, etc.; R3 = H, Me, 2,3-dihydroxypropyl, etc.; R4 = H or F; and X = CH(OH)CH2, (CH2)n; n = 1-3] were synthesized. All I demonstrated a potent anti-bronochoconstrictive effect in the guinea pig and some had a very long duration of action (> 48h). II was selected for clin. trials in asthmatic patients because of its long duration of action, its lack of central nervous system-stimulating effects and its inhibiting action on mast cell degranulation and phosphodiesterse activity. Structure-activity relationships are discussed. In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1Synthetic Route of C7H13NO2).

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C7H13NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Atkinson, Robert S. et al. published their research in Chemical Communications (Cambridge) in 1996 | CAS: 4045-22-1

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Reference of 4045-22-1

N-Acetyl-N-acyl-3-aminoquinazolinones as chemoselective acetylating agents was written by Atkinson, Robert S.;Barker, Emma;Sutcliffe, Michael J.. And the article was included in Chemical Communications (Cambridge) in 1996.Reference of 4045-22-1 This article mentions the following:

The title compounds, e.g. I, are highly selective acetylating agents for primary amines in the presence of secondary amines and, in particular, for the less sterically hindered of two different secondary amines. In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1Reference of 4045-22-1).

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Reference of 4045-22-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Yu, Ming-cheng et al. published their research in Acta Pharmacologica Sinica in 2021 | CAS: 4045-22-1

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-(4-Hydroxypiperidin-1-yl)ethanone

Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists was written by Yu, Ming-cheng;Yang, Feng;Ding, Xiao-yu;Sun, Nan-nan;Jiang, Zheng-yuan;Huang, Ya-fei;Yan, Yu-rong;Zhu, Chen;Xie, Qiong;Chen, Zhi-feng;Guo, Si-qi;Jiang, Hua-liang;Chen, Kai-xian;Luo, Cheng;Luo, Xiao-min;Chen, Shi-jie;Wang, Yong-hui. And the article was included in Acta Pharmacologica Sinica in 2021.Name: 1-(4-Hydroxypiperidin-1-yl)ethanone This article mentions the following:

A series of 6-substituted carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators were discovered through 6-position modification guided by insights from the crystallog. profiles of the “short” inverse agonist 6. With the increase in the size of the 6-position substituents, the “short” inverse agonist 6 first reversed its function to agonists and then to “long” inverse agonists. The cocrystal structures of RORγt complexed with the representative “short” inverse agonist 6 (PDB: 6LOB), the agonist 7d (PDB: 6LOA) and the “long” inverse agonist 7h (PDB: 6LO9) were revealed by X-ray anal. However, minor differences were found in the binding modes of “short” inverse agonist 6 and “long” inverse agonist 7h. To further reveal the mol. mechanisms of different RORγt inverse agonists, we performed mol. dynamics simulations and found that “short” or “long” inverse agonists led to different behaviors of helixes H11, H11′, and H12 of RORγt. The “short” inverse agonist 6 destabilizes H11′ and dislocates H12, while the “long” inverse agonist 7h separates H11 and unwinds H12. The results indicate that the two types of inverse agonists may behave differently in downstream signaling, which may help identify novel inverse agonists with different regulatory mechanisms. In the experiment, the researchers used many compounds, for example, 1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1Name: 1-(4-Hydroxypiperidin-1-yl)ethanone).

1-(4-Hydroxypiperidin-1-yl)ethanone (cas: 4045-22-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-(4-Hydroxypiperidin-1-yl)ethanone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Properties and Exciting Facts About 4045-22-1

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Recommanded Product: 1-(4-Hydroxypiperidin-1-yl)ethanone, Which mentioned a new discovery about 4045-22-1

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2. R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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Piperidine – Wikipedia,
Piperidine | C5H6854N – PubChem

 

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4045-22-1, molcular formula is C7H13NO2, introducing its new discovery. Recommanded Product: 1-(4-Hydroxypiperidin-1-yl)ethanone

The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer.

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More research is needed about 1-(4-Hydroxypiperidin-1-yl)ethanone

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Synthetic Route of 4045-22-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4045-22-1, Name is 1-(4-Hydroxypiperidin-1-yl)ethanone, molecular formula is C7H13NO2. In a Article，once mentioned of 4045-22-1

The title compounds, e.g. 3, are highly selective acetylating agents for primary amines in the presence of secondary amines and, in particular, for the less sterically hindered of two different secondary amines.

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Piperidine – Wikipedia,
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A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4045-22-1

Synthetic Route of 4045-22-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4045-22-1, Name is 1-(4-Hydroxypiperidin-1-yl)ethanone, molecular formula is C7H13NO2. In a Article，once mentioned of 4045-22-1

A novel series of 3-(2-substituted-3-oxo-2,3-dihydropyridazin-6-yl) -2-phenylpyrazolo[1,5-a]pyridines (5-38) were synthesized and evaluated for their in vitro adenosine A1 and A2A receptor binding activities, and in vitro metabolism by rat liver in order to search for orally active compounds. Most of the test compounds were potent adenosine A1 receptor antagonists with high A1 selectivity and the A1 affinity and A1 selectivity of carbonyl derivatives (5-11) was particularly high. In particular, compound 7 was an extremely potent and selective adenosine A1 antagonist with high A1 selectivity (Ki=0.026 nM, A2A/A1=5400). In terms of metabolic stability, 2-oxopropyl (5), 2-hydroxypropyl (12), N-methylacetamide (16), 2-(piperidin-1-yl)ethyl (28) and 1-methylpiperidin-4-yl (32, FR194921) were the most stable compounds in this series of analogues. Further in vivo evaluation indicated that compounds 5, 13, 17, 28 and 32 were detected in both plasma and brain after oral administration in rats. In particular, 32 displayed good plasma and brain concentrations (dose: 32mg/kg (n=3); after 30 min, plasma conc.=3390±651 nM, brain conc.=3670±496 nM; after 60 min, plasma conc.=1580±348 nM, brain conc.=2143±434 nM), and a good brain/plasma ratio (1.11±0.060 (30 min), 1.39±0.172 (60 min)). As a result, we could show that 32 is a good candidate for an orally active adenosine A1 receptor antagonist with high blood-brain barrier permeability and good bioavailability (Ki=6.6 nM, A2A/A1=820, BA=60.6±4.9% (32 mg/kg)).

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Piperidine – Wikipedia,
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Some scientific research about 4045-22-1

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4045-22-1 is helpful to your research. COA of Formula: C7H13NO2

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4045-22-1, name is 1-(4-Hydroxypiperidin-1-yl)ethanone, introducing its new discovery. COA of Formula: C7H13NO2

The present invention provides a N – heteroaryl sulfonamide derivatives and preparation and application, the derivatives including its pharmaceutically acceptable salt and/or solvate. The invention experiments prove that, of the N – heteroaryl sulfonamide derivatives can be specifically combined and inhibit or reduce the potassium channel Kv1.3 activity, can be applied to humans or animals by Kv1.3 potassium channel abnormal activation of the autoimmune disease. The present invention provides inhibitors also includes the pharmaceutical composition of this compound, and is used for the preparation of such compounds. The derivatives of the general formula: (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4045-22-1 is helpful to your research. COA of Formula: C7H13NO2

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Piperidine – Wikipedia,
Piperidine | C5H6861N – PubChem

 

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4045-22-1, molcular formula is C7H13NO2, introducing its new discovery. Product Details of 4045-22-1

Regulators of the cardiovascular system and, in particular, in the treatment of hypertension having the formula STR1 wherein R is lower alkyl; X, is a 3- or 4-position substituent and is –(CH2)n CONR1 R2, –O(CH2)n CONR1 R2 or STR2 wherein n is 0, 1 or 2; R1 is hydrogen or lower alkyl, and R2 is lower alkyl; lower alkenyl, lower alkynyl, phenyl, substituted phenyl, C3 -C7 cycloalkyl; lower alkyl substituted by phenyl, substituted phenyl, C3 -C7 cycloalkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, lower alkoxycarbonyl, phenoxy, substituted phenoxy or –NR3 R4 wherein R3 and R4 each represent hydrogen, lower alkyl, lower alkanoyl or lower alkylsulfonyl; with the proviso that any O, N or halogen atom in R2 is separated by at least 2 carbon atoms from the nitrogen atom to which R2 is attached; or R1 and R2 taken together with the nitrogen atom to which they are attached form a morpholino group optionally substituted by one or two lower alkyl groups, or a 1,2,3,4-tetrahydroisoquinolyl group optionally substituted on the benzene ring portion by one or two lower alkoxy groups; the pharmaceutically acceptable bioprecursors therefor, and the pharmaceutically acceptable acid addition salts thereof.

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Piperidine – Wikipedia,
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