Category: 401566-79-8

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, in an article , author is Enciso, Alan E., once mentioned of 401566-79-8, Formula: C14H18N4.

p-Substituted Tris(2-pyridylmethyl)amines as Ligands for Highly Active ATRP Catalysts: Facile Synthesis and Characterization

A facile and efficient two-step synthesis ofp-substituted tris(2-pyridylmethyl)amine (TPMA) ligands to form Cu complexes with the highest activity to date in atom transfer radical polymerization (ATRP) is presented. In the divergent synthesis,p-Cl substituents in tris(4-chloro-2-pyridylmethyl)amine (TPMA(3Cl)) were replaced in one step and high yield by electron-donating cyclic amines (pyrrolidine (TPMA(PYR)), piperidine (TPMA(PIP)), and morpholine (TPMA(MOR))) by nucleophilic aromatic substitution. The [Cu-II(TPMA(NR2))Br](+)complexes exhibited larger energy gaps between frontier molecular orbitals and >0.2 V more negative reduction potentials than [Cu-II(TPMA)Br](+), indicating >3 orders of magnitude higher ATRP activity. [Cu-I(TPMA(PYR))](+)exhibited the highest reported activity for Br-capped acrylate chain ends in DMF, and moderate activity toward C-F bonds at room temperature. ATRP ofn-butyl acrylate using only 10-25 part per million loadings of [Cu-II(TPMA(NR2))Br](+)exhibited excellent control.

Interested yet? Read on for other articles about 401566-79-8, you can contact me at any time and look forward to more communication. Formula: C14H18N4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Allen, Norman S., once mentioned the application of 401566-79-8, Product Details of 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, molecular formula is C14H18N4, molecular weight is 242.32, MDL number is MFCD22398471, category is piperidines. Now introduce a scientific discovery about this category.

Perspectives on additives for polymers. Part 2. Aspects of photostabilization and role of fillers and pigments

In Part I of this two-part series the most important aspects of antioxidants (primary and secondary), processing aids, metal deactivators and some light stabilizers were described and highlighted together with their mechanisms, problems, and interactions. Emphasis was placed on synergism and antagonism in performances and color problems with a special insight regarding PVC. Part 2 of this article presents in a similar way general perspective on the type, mode of action, properties, uses, problems (and circumvention) of light stabilizers and of some important fillers and pigments. Montmorillonites, silica, carbon blacks, and titanium dioxide will be the main features with an emphasis on structure, activity, and formulations in polymer systems. Additive interactions between stabilizers and fillers/pigments is a major controlling factor in the end use performance from a physical, esthetic, structural, mechanical, and chemical point of view. Indeed, with filled polymers one enters an overly complex world of interactions giving rise to some extreme synergistic and often antagonistic problems which can in many cases destroy or even enhance the activity of functional processing additives. Several of these will be highlighted to provide the technologist with at least some experience such that one can be alert to any potential issues in formulating more complex packages where not just color but high performance is also required.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, in an article , author is Jevtic, Ivana I., once mentioned of 401566-79-8, Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Synthesis and pharmacological evaluation of novel cis and trans 3-substituted anilidopiperidines

Background 4-Anilidopiperidine class of synthetic opioid analgesics, with it’s representative fentanyl, are by far the most potent and clinically significant for the treatment of the severe chronic and surgical pain. However, side effects of mu-opioids are often quite serious. In order to improve the pharmacological profile of this class of opioid analgesics, a novel fentanyl analogs were designed, synthesized and evaluated in vivo for their antinociceptive activity. Methods The title compounds were prepared using known synthetic transformations, includingN-bromoacetamide mediated Hofmann rearrangement, highly selective carbamate cleavage with trimethylsilyl iodide and dehydration of carboxamide group to nitrile in the presence of SOCl2. The antinociceptive activity of the synthesized compounds was determined by tail-immersion and formalin test. Results The scalable synthetic route towards novel fentanyl analogs bearing nitrogen groups in position C(3)of piperidine ring is designed. In addition, Hofmann rearrangement was substantially improved for the more efficient synthesis of previously published 3-substituted fentanyl analogs. The series of ten fentanyl analogs was tested in vivo for their antinociceptive activity. The most potent compound of the series was found to becis-4, based on the determined ED(50)values in tail-immersion test. Conclusion Of ten compounds tested for their antinociceptive activity, compoundcis-4is characterized by high potency, rapid beginning and short duration of action and due to this might be incorporated in different pharmaceutical forms.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 401566-79-8, you can contact me at any time and look forward to more communication. Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a document, author is Lu, Chuanrui, introduce the new discover, SDS of cas: 401566-79-8.

Chemically stable poly(meta-terphenyl piperidinium) with highly conductive side chain for alkaline fuel cell membranes

Poly(arylene piperidine)s (PAPs) backbones, which do not contain unstable ether bonds, was synthesized by one-pot, metal-free superacid-catalyzed polymerization for anion exchange membranes (AEMs) preparation. Meta-terphenyl as a monomer of polymer to regulate the morphology and properties of AEM was also used due to its spatially torsional configuration instead of the recently reported linear structure of peta-terphenyl. Long flexible hydrophilic chains were grafted onto poly(meta terphenyl piperidinium) (m-PTP) backbone to form four cationic functionalized side chains, promoting efficient transfer of OH- and optimizing the hydrophilic/hydrophobic microphase separation structure. The resulting AEM shows a high ion conductivity of 164 mS/cm (mPTP-TFPE-21) at 80 degrees C. Furthermore, stable piperidine cation and long alkyl spacer chain contributed to the excellent alkali stability of m-PTP-TFPE-TQA membrane which shows only 11.67% and 12.73% degradation in ion conductivity and IEC, respectively, after soaking in 2 M NaOH at 80 degrees C for 1500 h. The peak power density of the H-2/O-2 single cell using m-PTP-TFPE-14 is 269 mW/cm(2) at a current density of 540 mA/cm(2) at 80 degrees C.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 401566-79-8 is helpful to your research. SDS of cas: 401566-79-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 401566-79-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Lau, Justin Kai-Chi, introduce new discover of the category.

Collision-induced dissociation of protonated fentanyl: A DFT study

The fragmentation pathways leading to the major products resulting from collision-induced dissociation of protonated fentanyl are investigated. Starting from a protonated fentanyl in a twist conformation, transfer of the proton from the piperidine to the amide nitrogen allows the lone pair of the piperidine nitrogen to assist in displacement of the amide group and results in ring-opening of the piperidine to yield an ion with m/z 188 (C13H18N+). This is the fragmentation pathway with the lowest energy barrier; the barrier to the loss of the phenethyl group as a phenonium or 1-phenylethyl cation from the nitrogen in the piperidine ring is 64 kJ mol(-1) higher in energy. At even higher collision energies a bicyclic ion, also with nominal m/z 188 but with different elemental composition (C12H14NO+), is formed after sequential losses of ethene and phenethylamine from protonated fentanyl. Possible pathways to ring opening of the piperidine ring of N-protonated fentanyl include nucleophilic attack by the amide oxygen or the phenyl ring on the piperidine ring. The two m/z 188 ions give different dissociation products; minor products in the mass spectrum of protonated fentanyl at m/z 146, 134 and 132 are all generated from the dominant m/z 188 ion, C13H18N+, whereas only a product at m/z 132 is formed from the C12H14NO+ ion.

Related Products of 401566-79-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 401566-79-8 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, formurla is C14H18N4. In a document, author is Liu, Yi-Wen, introducing its new discovery. Safety of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Asymmetric synthesis of (-)-sedacryptine through a diastereoselective Mannich reaction of N,O-acetals with ketones

An efficient diastereoselective approach to access the 3-hydroxy-2,6-disubstituted piperidine scaffold 1 has been developed through the Mannich process involving N,O-acetal (2S,3R)-6 and ketones in excellent yield with high diastereoselectivity (dr > 99 : 1). In addition, the utility of this convenient one-pot process is demonstrated by the asymmetric synthesis of (-)-sedacryptine 3.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 401566-79-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Yamaguchi-Sasaki, Toru, introduce new discover of the category.

Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors

Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections and a significant pathogen for both adults and children. Although two drugs have been approved for the treatment of RSV infections, the low therapeutic index of these drugs have led pharmaceutical companies to develop safe and effective small-molecule anti-RSV drugs. The pyrazolo[1,5-a]pyrimidine series of compounds containing a piperidine ring at the 2-position of the pyrazolo[1,5-a]pyrimidine scaffold are known as candidate RSV fusion (F) protein inhibitor drugs, such as presatovir and P3. The piperidine ring has been revealed to facilitate the formation of an appropriate dihedral angle between the pyrazolo[1,5-a]pyrimidine scaffold and the plane of the amide bond for exertion of anti-RSV activity. A molecular-dynamic study on newly designed compounds with an acyclic chain instead of the piperidine ring proposed and demonstrated a new series of pyrazolo[1,5-a]pyrimidine derivatives, such as 9c with a 1-methyaminopropyl moiety, showing similar dihedral angle distributions to those in presatovir. Compound 9c exhibited potent anti-RSV activity with an EC50 value of below 1 nM, which was similar to that of presatovir. A subsequent optimization study on the benzene ring of 9c led to the potent RSV F protein inhibitor 14f with an EC50 value of 0.15 nM. The possibility of improving the biological properties of anti-RSV agents by modification at the 7-position of pyrazolo[1,5-a]pyrimidine is also discussed.

Synthetic Route of 401566-79-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 401566-79-8 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Jadhav, Manoj M., introduce new discover of the category.

Structure-efficiency relationship of newly synthesized 4-substituted donor-pi-acceptor coumarins for dye-sensitized solar cells

Four (MC1-MC4) 4-substituted coumarin dyes having N,N-diethyl aniline as donor and rhodanine-3-acetic acid as acceptor have been synthesized for use in nano-crystalline TiO2-based dye-sensitized solar cells (DSSCs). The alteration at the 4-position of coumarin was carried out by substituting H atom by chlorine (-Cl), piperidine (-NC5H10), and cyano group (-CN) to study the effect of substitution on the efficiency of the DSSCs. All the dyes were characterised by H-1-NMR and C-13-NMR spectroscopy and CHN analysis. The absorption and emission spectra of these coumarin dyes were recorded in eight different solvents and show positive solvatochromism. The TiO2-based DSSCs were fabricated using the four dyes and their photovoltaic properties were estimated. A maximum efficiency of 4.60% was obtained for the MC4 device, which has an electron-withdrawing cyano group at the 4-position of coumarin, while 2.64% efficiency was obtained for the MC1 device, which has only hydrogen at the 4-position. The efficiencies of the MC2 and MC3 devices lie between those of MC1 and MC4, suggesting the significance of substitution at the 4-position. The introduction of a cyano group, which acts as an electron trap, increases the electron-withdrawing capacity of the dye; thus, more electron density is withdrawn from the donor, resulting in enhanced efficiency. These dyes were studied by using density functional theory (DFT) and time dependent density functional theory (TD-DFT) to obtain the vertical excitation, HOMO-LUMO energy levels, band gap and electron distribution in the ground and excited state. The calculated values showed good correlation with the experimental values. Our results suggest that substitution at the 4-position is essential for enhancing the efficiency of coumarin-based DSSCs.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 401566-79-8. Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, formurla is C14H18N4. In a document, author is Dooley, Charles J., III, introducing its new discovery. Recommanded Product: 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode’s Acylation Reagents

The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 401566-79-8, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Shady, Nourhan Hisham, introduce new discover of the category.

Dereplication Analysis and Antitrypanosomal Potential of the Red Sea Sponge Amphimedon sp. Supported by Molecular Modelling

The present investigation was oriented to the discovery of chemical compounds from the Red Sea spongeAmphimedonsp., as a source of active agents againstTrypanosoma brucei, the causal agent of human sleeping sickness. Dereplication analysis of the active fraction fromAmphimedonsp. using liquid chromatography coupled with high-resolution mass spectrometry revealed the chemical richness of this sponge with diverse alkaloidal classes such as purine, manzamine, bis-piperidine, and pyridine. Activity-guided fractionation of the total extract showed the antitrypanosomal activity concentrated in the ethyl acetate fraction (IC50 = 3.8 mu g/ml).In silicomodelling was carried out on the dereplicated compounds to provide an insight into their antitrypanosomal mechanism of action with docking study on eight trypanosomal proteins. Molecular dynamics was run for the complex of zamamidine D and ornithine decarboxylase, which illustrated that zamamidine D has the highest affinity to the ornithine decarboxylase enzyme. These results highlight the valuable chemical profile ofAmphimedonsp., as a lead source for antitrypanosomal natural products.

Related Products of 401566-79-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 401566-79-8.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem