In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 400797-94-6, name is tert-Butyl 4-(2-oxoindolin-1-yl)piperidine-1-carboxylate, introducing its new discovery. Quality Control of: tert-Butyl 4-(2-oxoindolin-1-yl)piperidine-1-carboxylate
Activation of the M1 and M4 muscarinic acetylcholine receptors is thought to play an important role in improving the symptoms of schizophrenia. However, discovery of selective agonists for these receptors has been a challenge, considering the high sequence homology and conservation of the orthosteric acetylcholine binding site among muscarinic acetylcholine receptor subtypes. We report in this study the discovery of novel N-substituted oxindoles as potent muscarinic acetylcholine receptor partial agonists selective for M1 and M4 over M2, M3, and M 5. Among these oxindoles, compound 1 showed high selectivity for the M1 and M4 receptors with remarkable penetration into the central nervous system. Compound 1 reversed methamphetamine- and apomorphine-induced psychosis-like behaviors with low potency to extrapyramidical and peripheral side effects.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 400797-94-6 is helpful to your research. Quality Control of: tert-Butyl 4-(2-oxoindolin-1-yl)piperidine-1-carboxylate
Reference:
Piperidine – Wikipedia,
Piperidine | C5H23504N – PubChem