Category: 40064-34-4

40064-34-4, Piperidine-4,4-diol hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 62 N-t-Butoxycarbonyl-4-piperidone A solution of di-t-butyl dicarbonate (56.8 g, 0.26 mole) in acetonitrile (100 ml) was added dropwise to a stirred, ice-cooled suspension of 4-piperidone hydrochloride monohydrate (40.0 g, 0.26 mole) in triethylamine (26.3 g, 0.26 mole) and acetonitrile (300 ml). After a further 5 days the reaction mixture was filtered and the filtrate evaporated under reduced pressure to give an off-white solid (69 g) which was purified by chromatography on silica gel, using hexane:ether (1:1) as eluant, to provide the title compound (37.5 g) as a white solid, m.p. 74-75 C. Rf 0.60 (SS 17). Found: C,60.36; H,8.78; N,6.88. C10 H17 NO3 requires C,60.28; H,8.60; N,7.03%., 40064-34-4

As the paragraph descriping shows that 40064-34-4 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5917034; (1999); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

40064-34-4, Piperidine-4,4-diol hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,40064-34-4

Step 1 To a stirred, 0 C. solution of 4-piperidinone hydrochloride hydrate (50 g; 0.33 mol) in DMF (500 mL) was added di-t-butyldicarbonate (64 g; 0.29 mol) followed by a dropwise addition of DIEA (63 mL; 0.36 mol). After the addition of DIEA was complete, the reaction was allowed to gradually warm to ambient temperature over 4 h and stirring was continued for 20 h. The DMF was removed under reduced pressure and the residue was dissolved in EtOAc (1000 mL) and washed with 5% aqueous citric acid (2*500 mL), water (250 mL), and saturated aqueous NaHCO3 (500 mL). The EtOAc layer was dried (Na2 SO4), filtered, and the EtOAc was removed under reduced pressure. The residue was boiled in ether (ca. 250 mL) until the solid had dissolved. Cooling gave N-t-butyloxycarbonyl-4-piperidinone as white crystals (47 g; 80% yield).

40064-34-4 Piperidine-4,4-diol hydrochloride 33721, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US5665719; (1997); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem