Category: 4005-49-6

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, formurla is C12H9N5O. In a document, author is Mondal, Paramita, introducing its new discovery. Safety of N-(7H-Purin-6-yl)benzamide.

Use of an efficient polystyrene-supported cerium catalyst for one-pot multicomponent synthesis of spiro-piperidine derivatives and click reactions in green solvent

One-pot multicomponent reactions are very demanding in synthetic organic chemistry. Here we report a new polystyrene-supported cerium catalyst (PS-Ce-amtp) obtained via an easy two-step procedure, which was thoroughly characterized using various techniques. PS-Ce-amtp catalyses the environmentally benign one-pot multicomponent synthesis of spiro-piperidine derivatives through the reaction of substituted aniline, cyclic active methylene compound and formaldehyde at room temperature. The catalyst also exhibits excellent catalytic activity in one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles via click reaction between in situ generated azides (derived from anilines and amines) and terminal alkynes. The catalyst can be recovered easily after reaction and reused five times without significant loss in its catalytic activity. The advantageous features of this catalyst are atom economy, operational simplicity, short reaction times, easy handling and high recycling efficiency.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4005-49-6 help many people in the next few years. Safety of N-(7H-Purin-6-yl)benzamide.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is de Castro, Sonia, once mentioned the application of 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, molecular formula is C12H9N5O, molecular weight is 239.23, MDL number is MFCD00037927, category is piperidines. Now introduce a scientific discovery about this category, Application In Synthesis of N-(7H-Purin-6-yl)benzamide.

N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction

The influenza virus hemagglutinin (HA) is an attractive target for antiviral therapy due to its essential role in mediating virus entry into the host cell. We here report the identification of a class of N-benzyl-4,4,-disubstituted piperidines as influenza A virus fusion inhibitors with specific activity against the H1N1 subtype. Using the highly efficient one-step Ugi four-component reaction, diverse library of piperidine-based analogues was synthesized and evaluated to explore the structure-activity relationships (SAR). Mechanistic studies, including resistance selection with the most active compound (2) demonstrated that it acts as an inhibitor of the low pH-induced HA-mediated membrane fusion process. Computational studies identified an as yet unrecognized fusion inhibitor binding site, which is located at the bottom of the HA(2) stem in close proximity to the fusion peptide. A direct pi-stacking interaction between the N-benzylpiperidine moiety of 2 and F9(HA2) of the fusion peptide, reinforced with an additional pi-stacking interaction with Y119(HA2), and a salt bridge of the protonated piperidine nitrogen with E120(HA2), were identified as important interactions to mediate ligand binding. This site rationalized the observed SAR and provided a structural explanation for the H1N1-specific activity of our inhibitors. Furthermore, the HA(1)-S326V mutation resulting in resistance to 2 is close to the proposed new binding pocket. Our findings point to the N-benzyl-4,4,-disubstituted piperidines as an interesting class of influenza virus inhibitors, representing the first example of fusion peptide binders with great potential for anti-influenza drug development. (C) 2020 Elsevier Masson SAS. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 4005-49-6, Application In Synthesis of N-(7H-Purin-6-yl)benzamide.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, formurla is C12H9N5O. In a document, author is Griera, Rosa, introducing its new discovery. COA of Formula: C12H9N5O.

Removal of the Chiral Inductor from Phenylglycinol-derived Tricyclic Lac-tams. Unexpected Generation of Chiral trans-Hydrochromene Lactones

In the search for synthetic routes for the preparation of cis-and trans-decahydroquinolin-2ones, a procedure for the generation of enantiopure trans-hydrochromene lactones, by treatment of (R)phenylglycinol-derived oxazoloquinolone lactams with Na/liq. NH3 followed by acidification, has been developed.

If you are hungry for even more, make sure to check my other article about 4005-49-6, COA of Formula: C12H9N5O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 4005-49-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a article, author is Alluri, Kiran Kumar, introduce new discover of the category.

Synthesis and evaluation of 4 ‘,5 ‘-dihydrospiro[piperidine-4,7 ‘-thieno [2,3-c]pyran] analogues against both active and dormant Mycobacterium tuberculosis

Need for new drugs to fight against tuberculosis (TB) is increasing day by day. In the present work we have taken a spiro compound (GSK 2200150A) reported by GSK as a lead and we modified the structure of the lead to study the antitubercular activity. For structure activity profiling twenty-one molecules have been synthesized, characterized and evaluated for their antimycobacterial potency against both active and dormant TB. Compound 06, 1-((4-methoxyphenyl) sulfonyl)-4′,5′-dihydrospiro[piperidine-4,7’-thieno[2,3-c]pyran] was found to be the most potent compound (MIC: 8.23 mu M) in active TB and was less effective than the lead but more potent than standard first line drug ethambutol. It was also found to be more efficacious than Isoniazid and Rifampicin and equipotent as Moxifloxacin against dormant Mycobacterium tuberculosis (MTB). Compound 06 also showed good inhibitory potential against over expressed latent MTB enzyme lysine epsilon-amino transferase with an IC50 of 1.04 +/- 0.32 mu M. This compound is a good candidate for drug development owing to potential against both active and dormant stages of MTB. (C) 2017 Elsevier Ltd. All rights reserved.

Related Products of 4005-49-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 4005-49-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, formurla is C12H9N5O. In a document, author is Matsuda, Daisuke, introducing its new discovery. Computed Properties of C12H9N5O.

Design, synthesis and biological evaluation of novel 7-azaspiro[3.5] nonane derivatives as GPR119 agonists

The design and synthesis of a novel class of 7-azaspiro[3.5] nonane GPR119 agonists are described. In this series, optimization of the right piperidine N-capping group (R-2) and the left aryl group (R-3) led to the identification of compound 54g as a potent GPR119 agonist. Compound 54g showed a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose lowering effect in diabetic rats. (C) 2018 Elsevier Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 4005-49-6, Computed Properties of C12H9N5O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, molecular formula is , belongs to piperidines compound. In a document, author is Bandari, Chandrasekhar, COA of Formula: C12H9N5O.

Oxo-Rhenium-Catalyzed Radical Addition of Benzylic Alcohols to Olefins

Although carbon radicals generated from a variety of alcohol derivatives have proven valuable in coupling and addition reactions, the direct use of alcohols as synthetically useful radical sources is less known. In this report, benzylic alcohols are shown to be effective radical precursors for addition reactions to alkenes when treated with triphenylphosphine or piperidine with the catalyst ReIO2(PPh3)(2) (I).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4005-49-6, in my other articles. COA of Formula: C12H9N5O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, COA of Formula: C12H9N5O, 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a document, author is Gazitua, Marcela, introduce the new discover.

Effect of the nature of the nucleophile and solvent on an SNAr reaction

The reaction of 2,4-dinitrobenzenesulfonyl chloride toward propylamine was kinetically evaluated in 19 organic solvents and 10 ionic liquids as reaction media. This study was compared with a previous study to experimentally show that solvent effects and the nature of the reacting pair drastically affect the reaction rate and the reaction mechanism. While the reaction of the reference electrophile 2,4-dinitrobenzenesulfonyl chloride with piperidine is favored in polar solvents with the ability to donate or accept hydrogen bonds, the reaction with propylamine is favored in solvents with the ability to accept hydrogen bonds.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4005-49-6. COA of Formula: C12H9N5O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a document, author is Sackus, Algirdas, introduce the new discover, SDS of cas: 4005-49-6.

One-pot synthesis of polycyclic heterocyclic compounds by condensation of 1-carbamoylmethyl-2,3,3-trimethyl-3H-indolium salts with pyridine-2, 3, and 4-and quinoline-4-carboxaldehydes

A one-pot synthesis of new polycyclic heterocyclic compounds was carried out via the condensation of 1-carbamoylmethyl-2,3,3-trimethyl-3H-indolium chloride with pyridine- and quinolinecarboxaldehydes. The heating of the aforementioned 3H-indolium salts with 1 eq. of pyridine-2, 3, and 4- or quinoline-4-carboxaldehyde in ethanol in the presence of piperidine as a catalyst provided 9a-12(pyridyl)ethenyll- or 9a-[2-(quinolyl)ethenyl]-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one derivatives as the main products. However, reaction outcome was dramatically different for the analogous reactions in acetic acid. In this case, the heating of the chloride with 2 eq. of pyridine-2-carboxaldehyde afforded derivatives of 9a-[3-(pyridin-2-yl)indolizin-2-yl]-9,9a-dihydro-1H-imidazo [1,2-a]indol-2(3H)-one as the major product, while the use of 2 eq. of pyridine-3 and 4- or quinoline-4-carboxaldehyde led to the formation 2-heteroaryl-1-heteroarylmethyl-9H-pyrrolo[1,2-a]indole-3-carboxamides. Plausible pathways for the cyclization reactions are discussed. The structural assignments were based on H-1, C-13 and N-15 NMR spectroscopy, HRMS and single-crystal X-ray diffraction data. (C) 2018 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4005-49-6 is helpful to your research. SDS of cas: 4005-49-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 4005-49-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, SMILES is O=C(NC1=C2NC=NC2=NC=N1)C3=CC=CC=C3, belongs to piperidines compound. In a article, author is Ferreira, Renata C. M., introduce new discover of the category.

The Involvement of the Endocannabinoid System in the Peripheral Antinociceptive Action of Ketamine

A Ketamine has been widely used as an analgesic and produces dissociative anesthetic effects. The antinociceptive effects of ketamine have been studied, but the involvement of endocannabinoids in these effects has not yet been investigated. In this study, we evaluated the involvement of the endocannabinoid system in the peripheral antinociceptive effects induced by ketamine. All drugs were administered via the intraplantar route. To induce hyperalgesia, rat paws were injected with prostaglandin E-2 (2 mu g per paw). The nociceptive threshold for mechanical stimulation was measured in the right hind paw of Wistar rats using the Randall-Selitto test. The tissue levels of anandamide (AEA), 2-arachidonoylglycerol, palmitoylethanolamide, and oleoylethanolamide were measured using liquid chromatography coupled to single quadrupole mass spectrometry. The administration of the cannabinoid receptor type 1 (CB1) antagonist, N(piperidine-1yl)-5-(4-iodophenyl)-1-(2,4-dichloro phenyl)-4-methyl 1 pyrazolcarboxamide (20, 40, and 80 mu g per paw), but not the cannabinoid receptor type 2 antagonist, 6-iodo-2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl) (4-methoxyphenyl) methanone (100 mu g per paw), antagonized the ketamine-induced peripheral antinociception in a dose-dependent manner. Additionally, the administration of the endocannabinoid metabolizing enzyme inhibitor (.5 mu g per paw) or an AEA reuptake inhibitor, (5Z,82,11Z,14Z)N(4Hydroxy2methylphenyl)5,8, 11,14 eicosatetraenamide (2.5 mu g per paw) significantly enhanced low-dose ketamine-induced peripheral antinociception. AEA paw levels were increased only after ketamine administration to prostaglandin E-2-injected paws. These data suggest that ketamine, in the presence of a nociceptive stimulus, induces a selective release of AEA levels and subsequent CB1 cannabinoid activation at the peripheral level. Perspective: This study suggests that ketamine antinociception depends at least in part on AEA release and CB1 cannabinoid receptor activation in inflammatory conditions. This study could potentially help clinicians in the use of ketamine as a peripheral analgesic for inflammatory pain. (C) 2017 by the American Pain Society.

Synthetic Route of 4005-49-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 4005-49-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Shashi, R., once mentioned the application of 4005-49-6, Name is N-(7H-Purin-6-yl)benzamide, molecular formula is C12H9N5O, molecular weight is 239.23, MDL number is MFCD00037927, category is piperidines. Now introduce a scientific discovery about this category, Name: N-(7H-Purin-6-yl)benzamide.

One-Pot Synthesis of 1,4-Dihydropyridine Derivatives and Their X-Ray Crystal Structures: Role of Fluorine in Weak Interactions

1,4-dihydropyridines, namely diethyl 4-(4-fluorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(1a), diethyl 2,6-dimethyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate(1b), and diethyl 4-(3,4-dimethoxyphenyl)-2,6-dihydroxy-2,6-bis(trifluoromethyl)piperidine-3,5-dicarboxylate(2), are synthesized by one-pot multicomponent condensation of aromatic aldehyde with ethyl acetoacetate and liquid ammonia in the presence of an ethanol-water mixture and are characterized by single crystal X-ray diffraction. The effect of a fluorine atom on the dihydropyridine nucleus give insight into the self-assembly of compounds with various types of non-covalent interactions that greatly affect the crystal packing.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 4005-49-6, Name: N-(7H-Purin-6-yl)benzamide.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem