Category: 39512-49-7

Wang, Dongping; Mao, Jincheng; Zhu, Chen published an article in 2018, the title of the article was Visible light-promoted ring-opening functionalization of unstrained cycloalkanols via inert C-C bond scission.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A novel, useful, visible light-promoted ring-opening functionalization of unstrained cycloalkanols was described. Upon scission of an inert cyclic C-C σ-bond, a set of medium- and large-sized rings were readily brominated under mild reaction conditions to afford the corresponding distal bromo-substituted alkyl ketones that were hard to synthesize otherwise. The products were versatile building blocks, which were easily converted to other valuable mols. in one-step operation. This protocol was also applicable to the unprecedented ring-opening cyanation and alkynylation of unstrained cycloalkanols. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to cycloalkanol iridium photocatalyst ring opening bromination, bromoalkyl ketone preparation, Aliphatic Compounds: Ketones and Derivatives, Including Sulfur Analogs and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On March 13, 2013, Bao, Xiaofeng; Liu, Duliang published an article.COA of Formula: C11H14ClNO The title of the article was Radiosynthesis of 18F-labeled N-desmethyl-loperamide analogues for prospective molecular imaging radiotracers. And the article contained the following:

A simple procedure for preparing fluoroethyl-N-desmethyl-loperamide and its analog I [X = (CH2)2, (CH2)3, Y = F] was developed. Standard compound I [X = (CH2)2, Y = F] was synthesized in useful yields for radiolabeling anal. [N-Ethyl-18F]N-desmethyl-loperamide, I [X = (CH2)2, Y = 18F], was rapidly and efficiently labeled with no-carrier added fluorine-18 (t1/2 = 109.7 min) by treatment of readily prepared [18F]1-bromo-2-fluoroethane with a N-desmethyl-loperamide precursor at a consistent 7% radiochem. yield. This procedure was also adapted to the radiosynthesis of I [X = (CH2)2, Y = 18F] by [18F]ethylene tosylate, but at a lower 3% radiochem. yield. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO

The Article related to loperamide analog radiosynthesis loperamide fluorine 18 pet permeability glycoprotein, Heterocyclic Compounds (One Hetero Atom): Other 6-Membered Rings and other aspects.COA of Formula: C11H14ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Wang, Dongping; Mao, Jincheng; Zhu, Chen published an article in 2018, the title of the article was Visible light-promoted ring-opening functionalization of unstrained cycloalkanols via inert C-C bond scission.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A novel, useful, visible light-promoted ring-opening functionalization of unstrained cycloalkanols was described. Upon scission of an inert cyclic C-C σ-bond, a set of medium- and large-sized rings were readily brominated under mild reaction conditions to afford the corresponding distal bromo-substituted alkyl ketones that were hard to synthesize otherwise. The products were versatile building blocks, which were easily converted to other valuable mols. in one-step operation. This protocol was also applicable to the unprecedented ring-opening cyanation and alkynylation of unstrained cycloalkanols. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to cycloalkanol iridium photocatalyst ring opening bromination, bromoalkyl ketone preparation, Aliphatic Compounds: Ketones and Derivatives, Including Sulfur Analogs and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On August 25, 2016, Damont, Annelaure; Goutal, Sebastien; Auvity, Sylvain; Valette, Heric; Kuhnast, Bertrand; Saba, Wadad; Tournier, Nicolas published an article.Reference of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [11C]-N-desmethyl-loperamide PET study in nonhuman primates. And the article contained the following:

Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro. Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available (i.e. marketed) P-gp inhibitors are needed as probes to investigate the role of P-gp at the human BBB. In this study, the P-gp inhibition potency at the BBB of therapeutic doses of CsA or DPy was evaluated in baboons using Positron Emission Tomog. (PET) imaging with [11C]-N-desmethyl-loperamide ([11C]dLop), a radiolabeled P-gp substrate. The preparation of dLop as authentic standard and [11C]dLop as radiotracer were revisited so as to improve their production yields. [11C]dLop PET imaging was performed in the absence (n = 3, baseline condition) and the presence of CsA (15 mg/kg/h i.v., n = 3). Three animals were injected with i.v. DPy at either 0.56 or 0.96 or 2 mg/kg (n = 1), corresponding to the usual, maximal and twice the maximal dose in patients, resp., administered immediately before PET. [11C]dLop brain kinetics as well as [11C]dLop kinetics and radiometabolites in arterial plasma were measured to calculate [11C]dLop area-under the time-activity curve from 10 to 30 min in the brain (AUCbrain) and in plasma (AUCplasma). [11C]dLop brain uptake was described by AUCR = AUCbrain/AUCplasma. CsA as well as DPy did not measurably influence [11C]dLop plasma kinetics and metabolism Baseline AUCR (0.85 ± 0.29) was significantly enhanced in the presence of CsA (AUCR = 10.8 ± 3.6). Injection of pharmacol. dose of DPy did not enhance [11C]dLop brain distribution with AUCR being 1.2, 0.9 and 1.1 after administration of 0.56, 0.96 and 2 mg/kg DPy doses, resp. We used [11C]dLop PET imaging in baboons, a relevant in vivo model of P-gp function at the BBB, to show the P-gp inhibition potency of therapeutic dose CsA. Despite in vitro P-gp inhibition potency, usual doses DPy are not likely to inhibit P-gp function at the BBB. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Reference of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to cyclosporin a dipyridamole pgp inhibitor abcb1 drug interaction, bbb, drug-drug interaction, positron emission tomography, radiochemistry, stress-test, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Reference of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On September 23, 2021, Barbaraci, Carla; Giurdanella, Giovanni; Leotta, Claudia Giovanna; Longo, Anna; Amata, Emanuele; Dichiara, Maria; Pasquinucci, Lorella; Turnaturi, Rita; Prezzavento, Orazio; Cacciatore, Ivana; Zuccarello, Elisa; Lupo, Gabriella; Pitari, Giovanni Mario; Anfuso, Carmelina Daniela; Marrazzo, Agostino published an article.Synthetic Route of 39512-49-7 The title of the article was Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma. And the article contained the following:

Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults. (±)-MRJF22, a prodrug of the sigma (σ) ligand haloperidol metabolite II conjugated with the histone deacetylase (HDAC) inhibitor valproic acid, has previously demonstrated a promising antiangiogenic activity. Herein, the asym. synthesis of (R)-(+)-MRJF22 and (S)-(-)-MRJF22 was performed to investigate their contribution to (±)-MRJF22 antiangiogenic effects in human retinal endothelial cells (HREC) and to assess their therapeutic potential in primary human uveal melanoma (UM) 92-1 cell line. While both enantiomers displayed almost identical capabilities to reduce cell viability than the racemic mixture, (S)-(-)-MRJF22 exhibited the highest antimigratory effects in endothelial and tumor cells. Given the fundamental contribution of cell motility to cancer progression, (S)-(-)-MRJF22 (I) may represent a promising candidate for novel antimetastatic therapy in patients with UM. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Synthetic Route of 39512-49-7

The Article related to melanoma antimetastatic therapy vegf enantiomers antiangiogenic antiproliferative valproate ester, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Synthetic Route of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zhu, Xue Y.; Etukala, Jagan R.; Eyunni, Suresh V. K.; Setola, Vincent; Roth, Bryan L.; Ablordeppey, Seth Y. published an article in 2012, the title of the article was Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): A search for new dual-acting agents as potential antidepressants.HPLC of Formula: 39512-49-7 And the article contains the following content:

The synthesis and evaluation of several benzothiazole-based compounds are described in an attempt to identify novel dual-acting 5HT1A receptor and SERT inhibitors as new antidepressants. Binding affinities at the 5HT1A receptor and the serotonin transporter do not appear to be congruent and other areas of the binding sites would need to be explored in order to improve binding simultaneously at both sites. Compounds I and II show moderate binding affinity at the 5HT1A receptor and the SERT site and thus, have the potential to be further explored as dual-acting agents. In addition, compound I binds with low affinity to the dopamine transporter (DAT), the norepinephrine transporter (NET) and 5HT2C receptor, which are desirable properties as selectivity for SERT (and not DAT or NET) is associated with an absence of cardiovascular side effects. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).HPLC of Formula: 39512-49-7

The Article related to benzothiazole preparation 5ht1a receptor sert inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.HPLC of Formula: 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Klochkov, S. G.; Anan’ev, I. V.; Pukhov, S. A.; Afanas’eva, S. V. published an article in 2012, the title of the article was Stereochemistry of the aza-Michael reaction with natural alantolactones.Related Products of 39512-49-7 And the article contains the following content:

Hydrogenated 3-aminomethylnaphtho[2,3-b]furan-2-ones were synthesized by the reaction of natural alantolactones with pharmacophoric amines. Determination of the newly formed asym. center configuration by two-dimensional NMR data is presented. The structure of the obtained compounds was proved by X-ray structural anal. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7

The Article related to stereochem aza michael reaction natural alantolactone, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Related Products of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Cabrero-Antonino, Jose R.; Leyva-Perez, Antonio; Corma, Avelino published an article in 2012, the title of the article was Regioselective Hydration of Alkynes by Iron(III) Lewis/Bronsted Catalysis.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

The triflimide iron(III) salt [Fe(NTf2)3] promotes the direct hydration of terminal and internal alkynes with very good Markovnikov regioselectivities and high yields. The enhanced carbophilic Lewis acidity of the FeIII cation mediated by the weakly-coordinating triflimide anion is crucial for the catalytic activity. The iron(III) metal salt can be recycled as the OPPh3/[Fe(NTf2)3] system with similar activity and selectivity. However, spectroscopic and kinetic studies show that [Fe(NTf2)3] hydrolyzes under the reaction conditions and that catalytically less active Broensted species are formed, which points to a Lewis/Broensted co-catalysis. This triflimide-based catalytic system is regioselective for the hydration of internal aryl-alkynes and opens the door to a new synthetic route to alkyl ketophenones. As a proof of concept, the synthesis of two antipsychotics Haloperidol and Melperone, with general butyrophenone-like structure, is shown. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to regioselective hydration alkyne iron lewis broensted catalysis, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ibis, Cemil; Ayla, Sibel Sahinler; Ozkok, Funda; Bahar, Hakan published an article in 2015, the title of the article was Synthesis of New Piperazinyl and Piperidinolyl Substituted p-Chloranil Derivatives and their Reactions with Thiols.Safety of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

In continuation of previous studies of the nucleophilic substitution reactions of p-chloranil with nucleophiles, novel piperazinyl- and hydroxypiperidinyl-substituted quinones were synthesized. The N-substituted compounds were treated with some thiols and N,S-substituted compounds were obtained. The structures of new products were characterized by spectroscopic methods (1H NMR, 13C NMR, and MS) and elemental anal. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Safety of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to piperazinyl hydroxypiperidinyl chloranil derivative preparation thiol, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Safety of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Wang, Kaikai; Zeng, Rong published an article in 2022, the title of the article was Photoinduced Fe-catalyzed bromination and iodination of unstrained cyclic alcohols.Computed Properties of 39512-49-7 And the article contains the following content:

A photoinduced iron catalysis for the efficient C-C bond cleavage and bromination or iodination of unstrained tertiary cycloalkanols, e.g., 8-phenyl-1,4-Dioxaspiro[4.5]decan-8-ol with NBS/NIS was described. The reaction features good functional group tolerance and high yields under mild conditions and provides a powerful tool for the preparation of remote halogenated alkyl ketones, e.g., 3-[2-(2-bromoethyl)-1,3-dioxolan-2-yl]-1-phenyl-1-propanone. The products can be converted via nucleophilic substitution or cross-coupling to other valuable mols., such as haloperidol, fluanisone, and azabuperone, demonstrating the synthetic value of this reaction. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Computed Properties of 39512-49-7

The Article related to halo alkyl ketone preparation, cyclic alc iodosuccinimide bromosuccinimide halogenation iron photocatalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Computed Properties of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem