Category: 39512-49-7

Gitto, Rosaria; De Luca, Laura; Mancuso, Francesca; Del Prete, Sonia; Vullo, Daniela; Supuran, Claudiu T.; Capasso, Clemente published an article in 2019, the title of the article was Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A series of sixteen benzenesulfonamide derivatives has been synthesized and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship anal. highlighted that all tested compounds proved to be active inhibitors of VchCAα at nanomolar concentration The VchCAβ activity was lower to respect inhibitory efficacy toward VchCAα, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAγ. Interestingly, compound combined the best activity toward VchCAα and VchCAβ. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAβ. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to benzene sulfonamide derivative preparation carbonic anhydrase inhibitor cholera, carbonic anhydrase inhibitors (cais), benzenesulfonamides, molecular docking, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Guo, Yi-An; Lee, Wonchul; Krische, Michael J. published an article in 2017, the title of the article was Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.Related Products of 39512-49-7 And the article contains the following content:

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcs. and isoprene oxide. Based on this methodol., an oxetane containing analog of haloperidol was prepared A related azetidine formation is also described. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7

The Article related to enantioselective synthesis oxetane, iridium catalyst coupling primary alc isoprene oxide, enantioselectivity, iridium, oxetane, quaternary center, transfer hydrogenation, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Related Products of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ronson, Thomas O.; Renders, Evelien; Van Steijvoort, Ben F.; Wang, Xubin; Wybon, Clarence C. D.; Prokopcova, Hana; Meerpoel, Lieven; Maes, Bert U. W. published an article in 2019, the title of the article was Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 byproduct can be recycled. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to multicomponent reductive arylation amide arylboronate ester pyridinyl directing group, amides, amines, arylation, multicomponent reactions, ruthenium, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On August 31, 2014, Shimakami, Natsumi; Yabutani, Tomoki; Takayanagi, Toshio published an article.Name: 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Analysis of acid dissociation of photo-degradable haloperidol through the measurement of electrophoretic mobility by capillary zone electrophoresis. And the article contained the following:

The acid dissociation constants (Ka) of Haloperidol and its degraded product were determined by capillary zone electrophoresis (CZE). Haloperidol is degraded by UV-light irradiation, and 4-(p-chlorophenyl)-4-hydroxypiperidine (CPHP) is generated from Haloperidol. When the irradiated solution was analyzed by CZE, residual Haloperidol and two degraded products were detected. The acid dissociation constant of Haloperidol was determined through the electrophoretic mobility of the residual Haloperidol, and the pKa value determined was similar to that measured under no degradation conditions, as well as literature values. It was also confirmed that one of the degraded products was assigned to CPHP based on the migration time, the electrophoretic mobility, and its acid dissociation constant analyzed. It was demonstrated in this study that the acid dissociation constants are accurately determined by using CZE, even under degraded conditions of the analyte. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Name: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to haloperidol photodegradation acid dissociation constant capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Gitto, Rosaria; De Luca, Laura; Mancuso, Francesca; Del Prete, Sonia; Vullo, Daniela; Supuran, Claudiu T.; Capasso, Clemente published an article in 2019, the title of the article was Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A series of sixteen benzenesulfonamide derivatives has been synthesized and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship anal. highlighted that all tested compounds proved to be active inhibitors of VchCAα at nanomolar concentration The VchCAβ activity was lower to respect inhibitory efficacy toward VchCAα, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAγ. Interestingly, compound combined the best activity toward VchCAα and VchCAβ. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAβ. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to benzene sulfonamide derivative preparation carbonic anhydrase inhibitor cholera, carbonic anhydrase inhibitors (cais), benzenesulfonamides, molecular docking, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Guo, Yi-An; Lee, Wonchul; Krische, Michael J. published an article in 2017, the title of the article was Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.Related Products of 39512-49-7 And the article contains the following content:

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcs. and isoprene oxide. Based on this methodol., an oxetane containing analog of haloperidol was prepared A related azetidine formation is also described. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7

The Article related to enantioselective synthesis oxetane, iridium catalyst coupling primary alc isoprene oxide, enantioselectivity, iridium, oxetane, quaternary center, transfer hydrogenation, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Related Products of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sriramudu, B.; Satyanarayana, B.; Rao, S. Venkat; Krishna, N.; Murali, Krishna P.; Ramachandran, D. published an article in 2018, the title of the article was Synthesis and characterization of biological active compounds contain benzimidazole piperidine analogues.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A series of compounds namely, 1-(3-(piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-ones were synthesized from 1-(3-chloropropyl)-1H-benzo[d]imidazol-2(3H)-one and 4-substituted piperidines by using preamble chem. reactions, which exhibited good antibacterial and antifungal activities. They were structurally related to Domperidone, these results could help full for deriving more potential drug mols. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to chloropropyl benzimidazolone piperidine alkylation, piperidylpropyl benzimidazolone preparation antibacterial antifungal activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On March 13, 2013, Bao, Xiaofeng; Liu, Duliang published an article.COA of Formula: C11H14ClNO The title of the article was Radiosynthesis of 18F-labeled N-desmethyl-loperamide analogues for prospective molecular imaging radiotracers. And the article contained the following:

A simple procedure for preparing fluoroethyl-N-desmethyl-loperamide and its analog I [X = (CH2)2, (CH2)3, Y = F] was developed. Standard compound I [X = (CH2)2, Y = F] was synthesized in useful yields for radiolabeling anal. [N-Ethyl-18F]N-desmethyl-loperamide, I [X = (CH2)2, Y = 18F], was rapidly and efficiently labeled with no-carrier added fluorine-18 (t1/2 = 109.7 min) by treatment of readily prepared [18F]1-bromo-2-fluoroethane with a N-desmethyl-loperamide precursor at a consistent 7% radiochem. yield. This procedure was also adapted to the radiosynthesis of I [X = (CH2)2, Y = 18F] by [18F]ethylene tosylate, but at a lower 3% radiochem. yield. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO

The Article related to loperamide analog radiosynthesis loperamide fluorine 18 pet permeability glycoprotein, Heterocyclic Compounds (One Hetero Atom): Other 6-Membered Rings and other aspects.COA of Formula: C11H14ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On September 23, 2021, Barbaraci, Carla; Giurdanella, Giovanni; Leotta, Claudia Giovanna; Longo, Anna; Amata, Emanuele; Dichiara, Maria; Pasquinucci, Lorella; Turnaturi, Rita; Prezzavento, Orazio; Cacciatore, Ivana; Zuccarello, Elisa; Lupo, Gabriella; Pitari, Giovanni Mario; Anfuso, Carmelina Daniela; Marrazzo, Agostino published an article.Synthetic Route of 39512-49-7 The title of the article was Haloperidol Metabolite II Valproate Ester (S)-(-)-MRJF22: Preliminary Studies as a Potential Multifunctional Agent Against Uveal Melanoma. And the article contained the following:

Increased angiogenesis and vascular endothelial growth factor (VEGF) levels contribute to higher metastasis and mortality in uveal melanoma (UM), an aggressive malignancy of the eye in adults. (±)-MRJF22, a prodrug of the sigma (σ) ligand haloperidol metabolite II conjugated with the histone deacetylase (HDAC) inhibitor valproic acid, has previously demonstrated a promising antiangiogenic activity. Herein, the asym. synthesis of (R)-(+)-MRJF22 and (S)-(-)-MRJF22 was performed to investigate their contribution to (±)-MRJF22 antiangiogenic effects in human retinal endothelial cells (HREC) and to assess their therapeutic potential in primary human uveal melanoma (UM) 92-1 cell line. While both enantiomers displayed almost identical capabilities to reduce cell viability than the racemic mixture, (S)-(-)-MRJF22 exhibited the highest antimigratory effects in endothelial and tumor cells. Given the fundamental contribution of cell motility to cancer progression, (S)-(-)-MRJF22 (I) may represent a promising candidate for novel antimetastatic therapy in patients with UM. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Synthetic Route of 39512-49-7

The Article related to melanoma antimetastatic therapy vegf enantiomers antiangiogenic antiproliferative valproate ester, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Synthetic Route of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On August 25, 2016, Damont, Annelaure; Goutal, Sebastien; Auvity, Sylvain; Valette, Heric; Kuhnast, Bertrand; Saba, Wadad; Tournier, Nicolas published an article.Reference of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Imaging the impact of cyclosporin A and dipyridamole on P-glycoprotein (ABCB1) function at the blood-brain barrier: A [11C]-N-desmethyl-loperamide PET study in nonhuman primates. And the article contained the following:

Cyclosporin A (CsA) and dipyridamole (DPy) are potent inhibitors of the P-glycoprotein (P-gp; ABCB1) in vitro. Their efficacy at inhibiting P-gp at the blood-brain barrier (BBB) is difficult to predict. Efficient and readily available (i.e. marketed) P-gp inhibitors are needed as probes to investigate the role of P-gp at the human BBB. In this study, the P-gp inhibition potency at the BBB of therapeutic doses of CsA or DPy was evaluated in baboons using Positron Emission Tomog. (PET) imaging with [11C]-N-desmethyl-loperamide ([11C]dLop), a radiolabeled P-gp substrate. The preparation of dLop as authentic standard and [11C]dLop as radiotracer were revisited so as to improve their production yields. [11C]dLop PET imaging was performed in the absence (n = 3, baseline condition) and the presence of CsA (15 mg/kg/h i.v., n = 3). Three animals were injected with i.v. DPy at either 0.56 or 0.96 or 2 mg/kg (n = 1), corresponding to the usual, maximal and twice the maximal dose in patients, resp., administered immediately before PET. [11C]dLop brain kinetics as well as [11C]dLop kinetics and radiometabolites in arterial plasma were measured to calculate [11C]dLop area-under the time-activity curve from 10 to 30 min in the brain (AUCbrain) and in plasma (AUCplasma). [11C]dLop brain uptake was described by AUCR = AUCbrain/AUCplasma. CsA as well as DPy did not measurably influence [11C]dLop plasma kinetics and metabolism Baseline AUCR (0.85 ± 0.29) was significantly enhanced in the presence of CsA (AUCR = 10.8 ± 3.6). Injection of pharmacol. dose of DPy did not enhance [11C]dLop brain distribution with AUCR being 1.2, 0.9 and 1.1 after administration of 0.56, 0.96 and 2 mg/kg DPy doses, resp. We used [11C]dLop PET imaging in baboons, a relevant in vivo model of P-gp function at the BBB, to show the P-gp inhibition potency of therapeutic dose CsA. Despite in vitro P-gp inhibition potency, usual doses DPy are not likely to inhibit P-gp function at the BBB. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Reference of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to cyclosporin a dipyridamole pgp inhibitor abcb1 drug interaction, bbb, drug-drug interaction, positron emission tomography, radiochemistry, stress-test, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Reference of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem