Category: 39512-49-7

On April 30, 2022, Zhu, Zhenjun; Huang, Rui; Liu, Wei; Wang, Juan; Wu, Shujian; Chen, Mengfei; Huang, Aohuan; Xie, Yizhen; Chen, Moutong; Jiao, Chunwei; Zhang, Jumei; Wu, Qingping; Ding, Yu published an article.Reference of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Whole Agrocybe cylindracea Prevented Obesity Linking with Modification of Gut Microbiota and Associated Fecal Metabolites in High-Fat Diet-Fed Mice. And the article contained the following:

Whole-food-based strategies to prevent metabolic diseases are growing interests. Agrocybe cylindracea (AC) is a major edible mushroom with high values of nutrition, but little is known about its health benefits as a portion of whole food. Diet-induced obese, C57BL/6J mice are fed an high-fat diet (HFD) with or without AC (3% or 5%, weight/weight in the diet) for 9 wk. The results show that dietary AC reduced body weight, adipose accumulation, impairment of glucose tolerance, lipid levels, and liver injury in HFD-fed mice. Moreover, AC not only prevents HFD-induced gut disorder, as indicates by the enriched probiotic Bifidobacterium and reduced endotoxin-bearing Proteobacteria, but also improve the lipopolysaccharide (LPS) level and gut tissue structure. Fecal metabolites such as harmine and harmanine are also remarkably altered by AC. Spearman′s correlation anal. reveals that the AC-altered microbes and metabolites are strongly correlated with obesity-related indexes. These findings suggest that dietary AC prevents HFD-induced obesity and its complications in association with modulating gut microbiota and associated fecal metabolites. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Reference of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to agrocybe cylindracea prevent obesity gut microbiota metabolite hfd, agrocybe cylindracea, gut microbiota, high-fat diet, metabolites, whole food, Placeholder for records without volume info and other aspects.Reference of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On February 15, 2022, Dichiara, Maria; Artacho-Cordon, Antonia; Turnaturi, Rita; Santos-Caballero, Miriam; Gonzalez-Cano, Rafael; Pasquinucci, Lorella; Barbaraci, Carla; Rodriguez-Gomez, Isabel; Gomez-Guzman, Manuel; Marrazzo, Agostino; Cobos, Enrique J.; Amata, Emanuele published an article.Category: piperidines The title of the article was Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. And the article contained the following:

The development of σ1 receptor antagonists hybridized with a H2S-donor is here reported. We aimed to obtain improved analgesic effects when compared to σ1 receptor antagonists or H2S-donors alone. In an in vivo model of sensory hypersensitivity, thioamide 1a induced analgesia which was synergistically enhanced when associated with the σ1 receptor antagonist BD-1063. The selective σ1 receptor agonist PRE-084 completely reversed this effect. Four thioamide H2S-σ1 receptor hybrids (5a-8a) and their amide derivatives (5b-8b) were synthesized. Compound 7a (AD164) robustly released H2S and showed selectivity for σ1 receptor over σ2 and opioid receptors. This compound induced marked analgesia that was reversed by PRE-084. The amide analog 7b (AD163) showed only minimal analgesia. Further studies showed that 7a exhibited negligible acute toxicity, together with a favorable pharmacokinetic profile. To the best of our knowledge, compound 7a is the first dual-acting ligand with simultaneous H2S-release and σ1 antagonistic activities. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Category: piperidines

The Article related to pain analgesic effect pharmacokinetics antagonism, analgesia, antagonist, dual ligands, hydrogen sulfide donor, sigma-1 receptor, Placeholder for records without volume info and other aspects.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rafiq, Kiran; Saify, Zafar Saied; Vaid, Faiyaz; Navaid, Farzana; Kamil, Arfa; Kausar, Rana; Ghous, Asghari published an article in 2013, the title of the article was Synthesis of 4-(4′-chlorophenyl)-4-hydroxy piperidine analogues having promising compatibility with alpha amylase enzyme.Product Details of 39512-49-7 And the article contains the following content:

A new series of 4-(4′-Chlorophenyl)-4-hydroxy piperidine derivatives I·HX [R = adamantan-1-acyl, 6-methyluracil, 3-phenoxy-1-Pr, 3-phenyl-1-propyl] were synthesized with different phenacyl halide. All synthesized compounds were screened for their in vitro antiamylatic activity by semiquant. agar plate method. The parent compound 4-(4′-Chlorophenyl)-4-hydroxy piperidine showed moderate while I·HX [R = adamantan-1-acyl, 3-phenoxy-1-Pr, 3-phenyl-1-propyl] showed good antiamylatic activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Product Details of 39512-49-7

The Article related to chlorophenyl hydroxy piperidine preparation antiamylase, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On July 31, 2018, Rafiq, Kiran; Saify, Zafar Saied; Nesar, Shagufta; Faiyaz, Ambreen; Muhammad, Iyad Naeem published an article.COA of Formula: C11H14ClNO The title of the article was Some novel piperidine analogues having strong alpha glucosidase inhibition. And the article contained the following:

In the present work some hydroxy piperidine analogs have been synthesized and analyzed for their hypoglycemic effect through glucosidase inhibition owing to the structural resemblance with nojirimycin. The activity was done by spectral absorbance anal. using acarbose as standard Two analogs 1-(1”-phenoxypropyl)-4-phenyl-4-hydroxy piperidinium hydrobromide and 1-(1”-adamantan acyl)-4-(4′-bromophenyl)-4-hydroxy piperidinium hydrobromide were found to pose excellent activity having 87.4 and 54.7% inhibition resp., hence strengthening the idea of studying piperidine analogs as glucosidase inhibitors due to structural similarity with nojirimycin. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO

The Article related to piperidine derivative preparation alpha glucosidase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C11H14ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 1, 2014, Hatae, Noriyuki; Nagayama, Tomoyuki; Esaki, Hiroyoshi; Kujime, Eiko; Minami, Masabumi; Ishikura, Minoru; Choshi, Tominari; Hibino, Satoshi; Okada, Chiaki; Toyota, Eiko; Nagasawa, Hideko; Iwamura, Tatsunori published an article.Application of 39512-49-7 The title of the article was Synthesis of 4-arylpiperidin-4-ol derivatives of loperamide as agents with potent antiproliferative effects against HCT-116 and HL-60 cells. And the article contained the following:

The synthesis of 4-arylpiperidin-4-ol derivatives of loperamide I [R1 = n-Pr, Ph2C(OH)CH2, R2 = 4-ClC6H4; R1 = Ph2C(OH)CH2CH2, R2 = Ph, 4-ClC6H4, 3-F3CC6H4] and N-(3-hydroxy-3,3-diphenylpropyl)piperidine was carried out by alkylation of the corresponding N-unsubstituted piperidines. The synthesized compounds were tested for their antiproliferative activity against HCT-116 cells and HL-60 cells. The N-substituents on 4-arylpiperidin-4-ol units were found to play an important role in their antiproliferative activity, and the N-diphenylpropanol analogs exhibited the most potent antiproliferative activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application of 39512-49-7

The Article related to piperidinol aryl preparation loperamide antiproliferative activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ibis, Cemil; Ayla, Sibel Sahinler; Bahar, Hakan; Stasevych, Maryna V.; Komarovska-Porokhnyavets, Olena; Novikov, Volodymyr published an article in 2015, the title of the article was Synthesis, Characterization, and Biological Properties of Novel Piperidinolyl-, Piperidinyl-, and Piperazinyl-Substituted Naphthoquinone Compounds and Their Reactions With Some Thiols.Electric Literature of 39512-49-7 And the article contains the following content:

Nucleophilic substitution reactions of 2,3-dichloro-1,4-naphthoquinone were studied using a variety of piperidinol, piperidine, and piperazine derivatives The N-substituted compounds were treated with some thiols and N,S-substituted compounds were formed. The structures of the new products were characterized by spectroscopic methods (1H NMR, 13C NMR, MS) and elemental anal. The novel compounds were evaluated for their antibacterial and antifungal activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Electric Literature of 39512-49-7

The Article related to naphthoquinone derivative preparation antibacterial antifungal activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 11, 2018, Amata, Emanuele; Rescifina, Antonio; Prezzavento, Orazio; Arena, Emanuela; Dichiara, Maria; Pittala, Valeria; Montilla-Garcia, Angeles; Punzo, Francesco; Merino, Pedro; Cobos, Enrique J.; Marrazzo, Agostino published an article.Recommanded Product: 39512-49-7 The title of the article was (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. And the article contained the following:

Methoxycarbonyl-1-phenyl-2-cyclopropylmethyl based derivatives [cis-(+)-MR200], [cis-(-)-MR201], and [trans-(±)-MR204], have been identified as new potent sigma (σ) receptor ligands. In the present paper, novel enantiomerically pure analogs were synthesized and optimized for their σ receptor affinity and selectivity. Docking studies rationalized the results obtained in the radioligand binding assay. Absolute stereochem. was unequivocally established by X-ray anal. of a precursor as camphorsulfonyl derivative The most promising compound, I, showed remarkable selectivity over a panel of more than 15 receptors as well as good chem. and enzymic stability in human plasma. An in vivo evaluation evidenced that I, in contrast to its isomers, which behave as σ1 antagonists, exhibited a σ1 agonist profile. These data clearly demonstrated that compound I, due to its σ1 agonist activity and favorable receptor selectivity and stability, provided an useful tool for the study of σ1 receptors. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 39512-49-7

The Article related to cyclopropylmethyl piperidine receptor sigma ligand neurodegenerative disorder human, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Filer, Crist N.; Egan, Judith A.; Nugent, Richard P. published an article in 2014, the title of the article was Synthesis and characterization of [N-methyl-3H]loperamide.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

Loperamide is a piperidine butyramide mu-opiate receptor agonist and currently employed to treat diarrhea. Because a single past report of tritiating loperamide was limited to only a very low specific activity product without tech. details or extensive anal., the synthesis of [N-methyl-3H]loperamide at high specific activity was now described in detail. An imine precursor was alkylated with [3H]methyl iodide to obtain a quaternary intermediate, which was then reacted with 4-(4-chlorophenyl)-4-hydroxypiperidine to afford the desired product [N-methyl-3H]loperamide, characterized by thin layer chromatog. (TLC), HPLC, MS, UV, and proton-decoupled tritium NMR. Copyright © 2014 John Wiley & Sons, Ltd. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to tritium labeled loperamide synthesis, loperamide, mu-opiate receptor, tritium, tritium nmr, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On August 31, 2014, Shimakami, Natsumi; Yabutani, Tomoki; Takayanagi, Toshio published an article.Name: 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Analysis of acid dissociation of photo-degradable haloperidol through the measurement of electrophoretic mobility by capillary zone electrophoresis. And the article contained the following:

The acid dissociation constants (Ka) of Haloperidol and its degraded product were determined by capillary zone electrophoresis (CZE). Haloperidol is degraded by UV-light irradiation, and 4-(p-chlorophenyl)-4-hydroxypiperidine (CPHP) is generated from Haloperidol. When the irradiated solution was analyzed by CZE, residual Haloperidol and two degraded products were detected. The acid dissociation constant of Haloperidol was determined through the electrophoretic mobility of the residual Haloperidol, and the pKa value determined was similar to that measured under no degradation conditions, as well as literature values. It was also confirmed that one of the degraded products was assigned to CPHP based on the migration time, the electrophoretic mobility, and its acid dissociation constant analyzed. It was demonstrated in this study that the acid dissociation constants are accurately determined by using CZE, even under degraded conditions of the analyte. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Name: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to haloperidol photodegradation acid dissociation constant capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ronson, Thomas O.; Renders, Evelien; Van Steijvoort, Ben F.; Wang, Xubin; Wybon, Clarence C. D.; Prokopcova, Hana; Meerpoel, Lieven; Maes, Bert U. W. published an article in 2019, the title of the article was Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 byproduct can be recycled. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to multicomponent reductive arylation amide arylboronate ester pyridinyl directing group, amides, amines, arylation, multicomponent reactions, ruthenium, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem