Category: 39512-49-7

On September 19, 2022, Chen, Jia-Hao; Teng, Ming-Ya; Huang, Fan-Rui; Song, Hong; Wang, Zhen-Kai; Zhuang, He-Lin; Wu, Yong-Jie; Wu, Xu; Yao, Qi-Jun; Shi, Bing-Feng published an article.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Cobalt/Salox-Catalyzed Enantioselective Dehydrogenative C-H Alkoxylation and Amination. And the article contained the following:

Desymmetrization of diarylphosphinamides Ar2P(O)NHQ (Q = 8-quinolinyl) catalyzed by cobalt chiral Salox complexes (Salox = 2-(4-R-2-hydroxyphenyl)-4-phenyl-5-R1-oxazole) proceeds as dehydrogenative aromatic C-H alkoxylation and amination in one or both o-positions of one of the Ar rings. The past decade has witnessed a rapid progress in asym. C-H activation. However, the enantioselective C-H alkoxylation and amination with alcs. and free amines remains elusive. Herein, we disclose the first enantioselective dehydrogenative C-H alkoxylation and amination enabled by a simple cobalt/salicyloxazoline (Salox) catalysis. The use of cheap and readily available cobalt(II) salts as catalysts and Saloxs as chiral ligands provides an efficient method to access P-stereogenic compounds in excellent enantioselectivities (up to >99% ee). The practicality of this protocol is demonstrated by gram-scale preparation and further derivatizations of the resulting P-stereogenic phosphinamides, which offering a flexible asym. alternative to access P-stereogenic mono- and diphosphine chiral ligands. Preliminary mechanistic studies on the enantioselective C-H alkoxylation reaction suggest that a cobalt(III/IV/II) catalytic cycle might be involved. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to phosphinamide diaryl dehydrogenative alkoxylation amination desymmetrization cobalt salox catalyst, aromatic ch activation desymmetrization diarylphosphinamide alc amine cobalt catalyst, c−h alkoxylation, c−h amination, enantioselectivity, octahedral cobalt catalysis, salicyloxazoline and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On October 1, 2013, Wang, Min; Gao, Mingzhang; Zheng, Qi-Huang published an article.Reference of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was A high-yield route to synthesize the P-glycoprotein radioligand [11C]N-desmethyl-loperamide and its parent radioligand [11C]loperamide. And the article contained the following:

N-Desmethyl-loperamide and loperamide were synthesized from α,α-diphenyl-γ-butyrolactone and 4-(4-chlorophenyl)-4-hydroxypiperidine in five and four steps with 8% and 16% overall yield, resp. The amide precursor was synthesized from 4-bromo-2,2-diphenylbutyronitrile and 4-(4-chlorophenyl)-4-hydroxypiperidine in 2 steps with 21-57% overall yield. [11C]N-Desmethyl-loperamide and [11C]loperamide were prepared from their corresponding amide precursor and N-desmethyl-loperamide with [11C]CH3OTf through N-[11C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 20-30% and 10-15% radiochem. yields, resp., based on [11C]CO2 and decay corrected to end of bombardment (EOB), with 370-740 GBq/μmol specific activity at EOB. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Reference of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to radioligand desmethylloperamide loperamide preparation, butyrolactone hydroxypiperidine ring opening, automation, brain imaging, p-glycoprotein (p-gp), positron emission tomography (pet), [(11)c]loperamide, [(11)c]n-desmethyl-loperamide ([(11)c]dlop) and other aspects.Reference of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Redzicka, Aleksandra; Czyznikowska, Zaneta; Wiatrak, Benita; Gebczak, Katarzyna; Kochel, Andrzej published an article in 2021, the title of the article was Design and synthesis of N-substituted 3,4-pyrroledicarboximides as potential anti-inflammatory agents.COA of Formula: C11H14ClNO And the article contains the following content:

The biol. activity of the newly designed and synthesized series N-substituted 3,4-pyrroledicarboximides I [R = Bu, Ph, 3-chlorophenyl; R1 = hydroxy; R2 = 1-hydroxyethyl, pyrimidin-2-yl, cyclohexyl etc.; X = C, N, O] was described. The compounds I were obtained in good yields by one-pot, three-component condensation of pyrrolo[3,4-c]pyrroles with secondary amines and an excess of formaldehyde solution in C2H5OH. The structural properties of the compounds I were characterized by 1H NMR, 13C NMR FT-IR, MS, and elemental anal. Moreover, single crystal X-ray diffraction has been recorded for compound I [R = 3-chlorophenyl; R2 = cyclohexyl; X = N]. The colorimetric inhibitor screening assay was used and obtained their potencies and inhibited COX-1 and COX-2 enzymes. According to the results, all of the tested compounds I inhibited the activity of COX-1 and COX-2. Theor. modeling was also applied to describes the binding properties of compoundsI towards COX-1 and COX-2 cyclooxygenase isoform. The data were supported by QSAR study. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).COA of Formula: C11H14ClNO

The Article related to aminomethylpyrrolopyrroledione preparation antiinflammatory docking cyclooxygenase inhibitor analgesic antioxidant, cox-1/cox-2 inhibition, mannich bases, analgesic activity, cyclic imides, docking study, inflammatory agents, pyrrolo[3,4-c]pyrrole and other aspects.COA of Formula: C11H14ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zapol’skii, Viktor A.; Berneburg, Isabell; Bilitewski, Ursula; Dillenberger, Melissa; Becker, Katja; Jungwirth, Stefan; Shekhar, Aditya; Krueger, Bastian; Kaufmann, Dieter E. published an article in 2022, the title of the article was Chemistry of polyhalogenated nitrobutadienes, 17: efficient synthesis of persubstituted chloroquinolinyl-1H-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1H-pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thioperchloro-2-nitrobuta-1,3-dienes with 7-chloro-4-hydrazinylquinoline. A new way for the formation of a pyrazole cycle from 3-methyl-2-(2,3,3-trichloro-1-nitroallylidene)oxazolidine is also described. In addition, the antimalarial activity of the synthesized compounds has been evaluated in vitro against the protozoan malaria parasite Plasmodium falciparum. Notably, the I and 7-chloro-4-(3-((4-chlorophenyl)thio)-5-(dichloromethyl)-4-nitro-1H-pyrazol-1-yl)quinoline inhibited the growth of the chloroquine-sensitive Plasmodium falciparum strain 3D7 with EC50 values of 0.2 ± 0.1μM (85 ng/mL, 200 nM) and 0.2 ± 0.04μM (100 ng/mL, 200 nM), resp. Two compounds (I and II) have also been tested for anti-SARS-CoV-2, antibacterial, and cytotoxic activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to persubstituted chloroquinolinyl pyrazole preparation antimalarial antisars cov2 antibacterial cytotoxic, 1h-pyrazoles, 2-nitroperchlorobutadiene, anti-sars-cov-2 activity, antimalarial activity, chloroquine, nucleophilic vinylic substitution and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On July 25, 2022, Zhou, Jimei; Jia, Minxian; Song, Menghui; Huang, Zhiliang; Steiner, Alexander; An, Qidong; Ma, Jianwei; Guo, Zhiyin; Zhang, Qianqian; Sun, Huaming; Robertson, Craig; Bacsa, John; Xiao, Jianliang; Li, Chaoqun published an article.Related Products of 39512-49-7 The title of the article was Chemoselective Oxyfunctionalization of Functionalized Benzylic Compounds with a Manganese Catalyst. And the article contained the following:

Reported in this study is a new non-heme Mn catalyst stabilized by a bipiperidine-based tetradentate ligand, which enables methylene oxidation of benzylic compounds RCH2(CH2)nCH2R1 (R = Ph, 4-chlorophenyl, 2-bromophenyl, etc.; R1 = COOH, Me, Et, etc.) by H2O2, showing high activity and excellent chemoselectivity under mild conditions. The protocol tolerates an unprecedentedly wide range of functional groups, including carboxylic acid and derivatives, ketone, cyano, azide, acetate, sulfonate, alkyne, amino acid, and amine units, thus providing a low-cost, more sustainable and robust pathway for the facile synthesis of ketones RC(O)(CH2)nCH2R1, increase of complexity of organic mols., and late-stage modification of drugs. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7

The Article related to aryl ketone preparation chemoselective green chem, heterocyclic preparation chemoselective green chem, aromatic hydrocarbon oxidation manganese catalyst, benzylic oxidation, cyclic imines, ketones, manganese catalysts, selective oxidation and other aspects.Related Products of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zapol’skii, Viktor A.; Bilitewski, Ursula; Kupiec, Soeren R.; Ramming, Isabell; Kaufmann, Dieter E. published an article in 2020, the title of the article was Polyhalonitrobutadienes as versatile building blocks for the biotargeted synthesis of substituted N-heterocyclic compounds.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

Substituted nitrogen heterocycles are structural key units in many important pharmaceuticals. A new synthetic approach towards heterocyclic compounds displaying antibacterial activity against Staphylococcus aureus or cytotoxic activity has been developed. Selective synthesis of a series of 64 new N-heterocycles from the three nitrobutadienes, 2-nitroperchloro-1,3-butadiene, 4-bromotetrachloro-2-nitro-1,3-butadiene and (Z)-1,1,4-trichloro-2,4-dinitrobuta-1,3-diene, proved feasible. Their reactions of these butadienes with N-, O- and S-nucleophiles provided rapid access to push-pull substituted benzoxazolines, benzimidazolines, imidazolidines, thiazolidinones, pyrazoles, pyrimidines, pyridopyrimidines, benzoquinolines, isothiazoles, dihydroisoxazoles and thiophenes with unique substitution patterns. Antibacterial activities of the synthesized compounds were examined Seven studied compounds exhibited a significant cytotoxicity with IC50-values from 1.05 to 20.1μM. In conclusion, it was demonstrated that polyhalonitrobutadienes have an interesting potential as structural backbones for a variety of highly functionalized, pharmaceutically active heterocycles. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to butadiene nitro polyhalo preparation heterocyclization, nitrogen heterocycle preparation antitumor antibacterial activity, heterocyclization, medicinal chemistry, nitrogen heterocycles, nucleophilic substitution, polyhalonitrobutadienes and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On September 30, 2020, Szczukowski, Lukasz; Redzicka, Aleksandra; Wiatrak, Benita; Krzyzak, Edward; Marciniak, Aleksandra; Gebczak, Katarzyna; Gebarowski, Tomasz; Swiatek, Piotr published an article.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Design, synthesis, biological evaluation and in silico studies of novel pyrrolo[3,4-d]pyridazinone derivatives with promising anti-inflammatory and antioxidant activity. And the article contained the following:

Novel Mannich base analogs of pyrrolo[3,4-d]pyridazinone I (R1 = n-Bu, Ph; X = N, O, C; R2 = Ph, 4-MeC6H4, 2-pyridyl, etc.; R3 = OH) are designed and synthesized as potential anti-inflammatory agents. The title compounds are obtained via convenient one-pot synthesis with good yields. The aim of this study is to evaluate the inhibitory activity of the new derivatives against both cyclooxygenase isoforms COX1 and COX2 as well as their cytotoxicity. The results clearly indicate that the tested compounds are not toxic, all show better affinity towards isoform COX-2, and some of them act as selective COX-2 inhibitors. Moreover, every examined compounds I demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam. Mol. docking studies confirm that all compounds preferably bind COX-2 and all of them bind to the active site of cyclooxygenase in a way very similar to meloxicam. Subsequently, synthesized Mannich bases are evaluated for potential antioxidant activity. Most of the investigated derivatives reduce induced oxidative and nitrosative stress. Moreover, some compounds protect chromatin from oxidative stress and decrease the number of DNA strand breaks caused by intracellular growth of free radicals. Finally, a study of the binding mechanism between compounds I and bovine serum albumin (BSA) was carried out and all examined derivatives interact with BSA, which suggests their potential long half-life in vivo. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to pyrrolopyridazinone preparation antiinflammatory antioxidant drug toxicity mol docking sar, 1,3,4-oxadiazole-2-thione, anti-inflammatory agents, antioxidants, cyclooxygenase inhibitors, mannich bases, molecular docking, pyridazinone and other aspects.Application In Synthesis of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On September 19, 2022, Zhang, Ke; Ren, Bai-Hao; Liu, Xiao-Fei; Wang, Lin-Lin; Zhang, Min; Ren, Wei-Min; Lu, Xiao-Bing; Zhang, Wen-Zhen published an article.Product Details of 39512-49-7 The title of the article was Direct and Selective Electrocarboxylation of Styrene Oxides with CO2 for Accessing β-Hydroxy Acids. And the article contained the following:

Highly selective and direct electroreductive ring-opening carboxylation of epoxides with CO2 in an undivided cell was reported. This reaction showed broad substrate scopes within styrene oxides under mild conditions, providing practical and scalable access to important synthetic intermediate β-hydroxy acids. Mechanistic studies show that CO2 functions not only as a carboxylative reagent in this reaction but also as a promoter to enable efficient and chemoselective transformation of epoxides under additive-free electrochem. conditions. Cathodically generated α-radical and α-carbanion intermediates leaded to the regioselective formation of α-carboxylation products. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Product Details of 39512-49-7

The Article related to epoxide carbon dioxide regioselective chemoselective electroreductive ring opening carboxylation, hydroxyalkyl carboxylic acid preparation, carbon dioxide fixation, carboxylation, epoxides, hydroxy acids, organic electrosynthesis and other aspects.Product Details of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On January 27, 2015, Sozio, Piera; Fiorito, Jole; Di Giacomo, Viviana; Di Stefano, Antonio; Marinelli, Lisa; Cacciatore, Ivana; Cataldi, Amelia; Pacella, Stephanie; Turkez, Hasan; Parenti, Carmela; Rescifina, Antonio; Marrazzo, Agostino published an article.Computed Properties of 39512-49-7 The title of the article was Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells. And the article contained the following:

In a previous work the authors reported the antiproliferative effects of (±)-MRJF4, a novel haloperidol metabolite II (HP-mII) (a sigma-1 antagonist and sigma-2 agonist) prodrug, obtained through conjugation to 4-phenylbutyric acid (PhBA) [a histone deacetylase inhibitor (HDACi)] by an ester bond. As a continuation of this work, here the authors report the asym. synthesis of compounds Benzenebutanoic acid 4-[(1R)-4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)butyl ester [(R)-(+)-MRJF4] and 4-[(1R)-4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)butyl ester [(S)-(-)-MRJF4] and the evaluation of their biol. activity on rat C6 glioma cells, derived from glioblastoma multiforme (GBM), which is the most common and deadliest central nervous system (CNS) invasive malignancy. Favorable physicochem. properties, high permeability in the parallel artificial membrane permeability assay (PAMPA), good enzymic and chem. stability, in vivo anticancer activity, associated with the capacity to reduce cell viability and to increase cell death by apoptosis, render compound (R)-(+)-MRJF4 a promising candidate for the development of a useful therapeutic for glioma therapy. The synthesis of the target compounds was achieved by a reaction of (αS)-4-(4-chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidienbutanol or (αR)-4-(4-chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidienbutanol with benzenebutanoyl chloride. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Computed Properties of 39512-49-7

The Article related to haloperidol metabolite prodrug anticancer antitumor glioma, benzenebutanoic acid hydroxypiperidine preparation anticancer agent cns glioma, glioma, hdac, inhibitors, medicinal chemistry, sigma receptors and other aspects.Computed Properties of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On October 18, 2019, Lin, Zhiyang; Lan, Yun; Wang, Chuan published an article.Formula: C11H14ClNO The title of the article was Reductive Allylic Defluorinative Cross-Coupling Enabled by Ni/Ti Cooperative Catalysis. And the article contained the following:

Tertiary alkyl chlorides, secondary alkyl chlorides and bromides, and primary alkyl bromides underwent chemoselective defluorinative cross-coupling reactions with α-trifluoromethyl aryl alkenes in the presence of (indenyl)TiCl3, NiBr2, and 3,4,7,8-tetramethyl-1,10-phenanthroline to yield α-substituted aryl difluoroalkenes such as 4-MeOC6H4C(:CF2)CH2R (R = t-Bu, cyclohexyl, n-octyl). Unfunctionalized and ester-functionalized alkyl halides underwent cross-coupling under the reaction conditions, while a variety of functionalized aryl alkenes underwent cross-coupling. Using this method, gem-difluoroalkene analogs of azaperone, haloperidol, and benperidol were prepared The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Formula: C11H14ClNO

The Article related to alkyl aryl difluoroalkene chemoselective preparation, nickel titanium catalyst reductive defluorinative coupling trifluoromethylalkene chloroalkane bromoalkane, tertiary secondary chloroalkane reductive defluorinative coupling trifluoromethyl aryl alkene, secondary primary bromoalkane reductive defluorinative coupling trifluoromethyl aryl alkene and other aspects.Formula: C11H14ClNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem