Category: 388077-74-5

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 388077-74-5, Name is 1-Boc-2-piperidinamide, molecular formula is C11H20N2O3. In an article, author is Dias Viegas, Flavia Pereira,once mentioned of 388077-74-5, Safety of 1-Boc-2-piperidinamide.

Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates

A new series of sixteen multifunctional N-benzyl-piperidine-aryl-acylhydrazones hybrid derivatives was synthesized and evaluated for multi-target activities related to Alzheimer’s disease (AD). The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. Among them, compounds 4c, 4d, 4g and 4j presented the best AChE inhibitory activities, but only compounds 4c and 4g exhibited concurrent anti-inflammatory activity in vitro and in vivo, against amyloid beta oligomer (A beta O) induced neuroinflammation. Compound 4c also showed the best in vitro and in vivo neuroprotective effects against A beta O-induced neurodegeneration. In addition, compound 4c showed a similar binding mode to donepezil in both acetylated and free forms of AChE enzyme in molecular docking studies and did not show relevant toxic effects on in vitro and in vivo assays, with good predicted ADME parameters in silico. Overall, all these results highlighted compound 4c as a promising and innovative multi-target drug prototype candidate for AD treatment. (C) 2018 Elsevier Masson SAS. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 388077-74-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a article, author is Muzaffar, Saima, introduce new discover of the category.

Probing phenylcarbamoylazinane-1,2,4-triazole amides derivatives as lipoxygenase inhibitors along with cytotoxic, ADME and molecular docking studies

Hunting small molecules as anti-inflammatory agents/drugs is an expanding and successful approach to treat several inflammatory diseases such as cancer, asthma, arthritis, and psoriasis. Besides other methods, inflammatory diseases can be treated by lipoxygenase inhibitors, which have a profound influence on the development and progression of inflammation. In the present study, a series of new N-alkyl/aralky/aryl derivatives (7a-o) of 2-(4-phenyl-5-(1-phenylcarbamoyl)piperidine-4H-1,2,4-triazol-3-ylthio)acetamide was synthesized and screened for their inhibitory potential against the enzyme 15-lipoxygenase. The simple precursor ethyl piperidine-4-carboxylate (a) was successively converted into phenylcarbamoyl derivative (1), hydrazide (2), semicarbazide (3) and N-phenylated 5-(1-phenylcarbamoyl)piperidine-1,2,4-triazole (4), then in combination with electrophiles (6a-o) through further multistep synthesis, final products (7a-o) were generated. All the synthesized compounds were characterized by FTIR, H-1, C-13 NMR spectroscopy, EIMS, and HREIMS spectrometry. Almost all the synthesized compounds showed excellent inhibitory potential against the tested enzyme. Compounds 7c, 7f, 7d, and 7g displayed potent inhibitory potential (IC50 9.25 +/- 0.26 to 21.82 +/- 0.35 mu M), followed by the compounds 7n, 7h, 7e, 7a, 7b, 7l, and 7o with IC50 values in the range of 24.56 +/- 0.45 to 46.91 +/- 0.57 mu M. Compounds 7c, 7f, 7d exhibited 71.5 to 83.5% cellular viability by MTT assay compared with standard curcumin (76.9%) when assayed at 0.125 mM concentration. In silico ADME studies supported the drug-likeness of most of the molecules. In vitro inhibition studies were substantiated by molecular docking wherein the phenyl group attached to the triazole ring was making a pi-delta interaction with Leu607. This work reveals the possibility of a synthetic approach of compounds in relation to lipoxygenase inhibition as potential lead compounds in drug discovery.

Synthetic Route of 388077-74-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 388077-74-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 388077-74-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a article, author is Yin, Jinpeng, introduce new discover of the category.

Highly selective 1-pentene epoxidation over Ti-MWW with modified microenvironment of Ti active sites

A titanosilicate/H(2)O(2)catalytic system was applied to process the liquid-phase selective epoxidation of 1-pentene to 1,2-epoxypentane (EP). The effects of titanosilicate topology (MWW, MFI, MSE, MEL, MOR, and *BEA), solvent, H2O/H(2)O(2)ratio, catalyst amount, reaction temperature, pressure, and time on the EP production were investigated systematically. The Ti-MWW/H2O2/acetonitrile system exhibited the highest 1-pentene conversion of 72.9% together with high EP selectivity of 99.9% and H(2)O(2)utilization efficiency of 91.5%. Moreover, it was proved that the Ti active sites located inside the intralayer 10-membered ring sinusoidal channels catalyzed the epoxidation process primarily owing to their supplying more steric fitness for 1-pentene molecules. A piperidine (PI)-assisted structural rearrangement of Ti-MWW was performed to further enhance the catalytic activity, almost doubling the turnover number value. The evolution of the microenvironment of Ti active sites in this structural rearrangement process was carefully investigated, revealing the coordination of N atoms in PI molecules to the Ti atoms. More importantly, we identified that the hexa-coordinated Ti sites with the PI molecules as ligand could significantly accelerate H(2)O(2)activation, the effect of which far exceeded the inhibition effect caused by the electronegativity increase of Ti active sites.

Application of 388077-74-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 388077-74-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 388077-74-5, 388077-74-5, Name is 1-Boc-2-piperidinamide, molecular formula is C11H20N2O3, belongs to piperidines compound. In a document, author is Kaygusuz, Ozge, introduce the new discover.

The reactions of hexachlorocyclotriphosphazene with piperidine, N-(1-naphthyl)ethylenediamine and 2-(2-hydroxyethylamino)ethanol. Antimicrobial activities of iminodiethoxy-substituted cyclotriphosphazene derivatives

A series of cyclotriphosphazene derivatives (5-16) were synthesized from the reactions of hexachlorocyclotriphosphazene (1, N3P3Cl6) with piperidine (2),N-(1-naphthyl)ethylenediamine (3) and 2-(2-hydroxyethylamino)ethanol (4). Of the synthesized compounds, 2-piperidino-2,4,4,6,6-pentachlorocyclotri phosphazatriene, N3P3Cl5[N-(C5H10)] (5); 2,4-piperidino-2,4,6,6-tetrachlorocyclo triphosphazatriene, N3P3Cl4[N-(C5H10)](2)(6); 2,4,6-piperidino-2,4,6-trichlorocyclo triphosphazatriene, N3P3Cl3[N-(C5H10)](3)(7); 2,2,4,6-piperidino-4,6-dichlorocyclotri phosphazatriene, N3P3Cl2[N-(C5H10)](4)(8); the 2,4,6,6-tetrachloro-2,4-non-gem-N-(1-naphthyl)ethylendiamino)-cyclotri phosphazatriene, N3P3Cl4[NH-(CH2)(2)-NH-(C10H7)](2)(9); and the 2,2,4,4,6,6-trispiro-2,2 ‘-iminodiethoxy-cyclotriphosphazatriene, N3P3[O-(CH2)(2)-NH-(CH2)(2)O](3)(14) derivatives are reported for the first time, others (10-13,15and16) were previously reported. The derived compounds (5-16) were structurally elucidated by elemental analysis and spectral data of(1)H and(31)P NMR and TLC-MS. Water-soluble hexachlorocyclotriphosphazene derivatives (10-16) were screened for their antimicrobial activities against three human pathogens;Escherichia coliW3110,Staphylococcus aureusATCC 25923, andCandida albicansATCC 10231 and compounds10,12, and16found to exhibit significant antimicrobial activities against the indicated microorganism.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 388077-74-5. Product Details of 388077-74-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: piperidines, 388077-74-5, Name is 1-Boc-2-piperidinamide, molecular formula is C11H20N2O3, belongs to piperidines compound. In a document, author is Mitsudo, Koichi, introduce the new discover.

Stereoselective nucleophilic addition reactions to cyclic N-acyliminium ions using the indirect cation pool method: Elucidation of stereoselectivity by spectroscopic conformational analysis and DFT calculations

In this study, six-membered N-acyliminium ions were generated by the indirect cation pool method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good to excellent yields. The conformations of the obtained N-acyliminium ions were studied by low temperature NMR analyses and DFT calculations and were found to be consistent with the Steven’s hypothesis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 388077-74-5. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 388077-74-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a article, author is Martucci, Hana F. H., introduce new discover of the category.

Distribution of furanyl fentanyl and 4-ANPP in an accidental acute death: A case report

Fatalities from emerging synthetic opioids have continued to reach new epidemic proportions throughout the world in recent years. Due to the sparsity of research in new opioid analogs, commonly observed lethal concentrations and their distribution following death have yet to be well documented. The prevalence of furanyl fentanyl in postmortem casework contributes to the opioid related deaths that are amongst half of drug-induced fatalities in the United States. In this case study, a 23-year-old man was found dead in San Francisco following the ingestion of blue pills imitating oxycodone. Initial toxicology screening did not detect oxycodone in blood. However, a positive fentanyl immunoassay result was obtained and analysis of the pills collected at the scene showed the presence of furanyl fentanyl. Analysis of postmortem samples revealed concentrations of furanyl fentanyl at 1.9 ng/mL in peripheral blood, 2.8 ng/mL in cardiac blood, and similar to 55,000 ng in gastric contents. Metabolite 4-anilino-N-phenethyl-piperidine (4-ANPP) was also confirmed at 4.3 ng/mL and 5.8 ng/mL in peripheral blood and cardiac blood, respectively. Trace amounts of both analytes were detected in urine and the vitreous humor. Liver 4-ANPP concentrations of >40 ng/g were also detected. This case study of acute furanyl fentanyl overdose in a young male thought to be using oxycodone highlights illicit drug users are often subject to unknown drug entities. The toxicological analysis provides preliminary information of the distribution of furanyl fentanyl and its metabolite in a range of postmortem specimens and collection sites. (c) 2017 Elsevier B.V. All rights reserved.

Application of 388077-74-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 388077-74-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 388077-74-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a article, author is Bari, Ahmed, introduce new discover of the category.

The crystal structure of ethyl-1-(N-(adamantan-1-yl)-carbamothioyl)piperidine-4-carboxylate, C19H30N2O2S

C19H30N2O2S, monoclinic, P2(1)/n (no. 14), a = 6.4977(5) angstrom, b = 28.728(2) angstrom, c = 10.1806(8) angstrom, beta = 101.549(3)degrees, V = 1861.9(2) angstrom(3), Z = 4, R-gt(F) = 0.0460, WRref(F-2) = 0.1213, T = 296 K.

Synthetic Route of 388077-74-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 388077-74-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 388077-74-5, Name is 1-Boc-2-piperidinamide, molecular formula is , belongs to piperidines compound. In a document, author is Szczepanska, Katarzyna, Category: piperidines.

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands

As a continuation of our search for novel histamine H-3 receptor ligands, a series of twenty four new tertbutyl and tert-pentyl phenoxyalkylamine derivatives (2-25) was synthesized. Compounds with three to four carbon atoms alkyl chain spacer were evaluated for their binding properties at human histamine H-3 receptor (hH(3)R). The highest affinities were observed for 4-pyridyl derivatives 4, 10, 16 and 22 (K-i = 16.0 120 nM). As it has been shown in docking studies, those specific heteroaromatic 4-N piperazine substituents might interact with one of the key receptor interacting amino acids. Moreover, the most promising compounds exhibited anticonvulsant activity in the maximal electroshock-induced seizure (MES) model in mice. Furthermore, the blood-brain barrier penetration, the functional H3R antagonist potency as well as the pro-cognitive properties in the passive avoidance test were demonstrated for compound 10. In order to estimate drug-likeness of compound 10, in silico and experimental evaluation of metabolic stability in human liver microsomes was performed. In addition, paying attention to the results obtained within this study, the 4-pyridyl-piperazino moiety has been established as a new bioisosteric piperidine replacement in H3R ligands. (C) 2018 Published by Elsevier Masson SAS.

If you are hungry for even more, make sure to check my other article about 388077-74-5, Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 388077-74-5, Name is 1-Boc-2-piperidinamide, formurla is C11H20N2O3. In a document, author is Avagyan, A. S., introducing its new discovery. Safety of 1-Boc-2-piperidinamide.

Synthesis and Antibacterial Activity of New Oxadiazolylbenzodioxane Derivatives

Reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol with N-substituted chloroacetamides gave a series of the corresponding derivatives at the sulfur atom. Addition reactions of 5-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole-2-thiol to the C=C double bond of acrylonitrile, acrylamide, and ethyl acrylate, as well as Mannich condensation with morpholine and piperidine, were studied. The synthesized compounds were evaluated for their antibacterial activity.

If you are hungry for even more, make sure to check my other article about 388077-74-5, Safety of 1-Boc-2-piperidinamide.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 388077-74-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 388077-74-5, Name is 1-Boc-2-piperidinamide, SMILES is O=C(C1N(C(OC(C)(C)C)=O)CCCC1)N, belongs to piperidines compound. In a article, author is Maram, Lingaiah, introduce new discover of the category.

Switching Electrophile Intermediates to Nucleophiles: Michael and Oxa-Diels-Alder Reactions to Afford Polyoxy-Functionalized Piperidine Derivatives with Tetrasubstituted Carbon

Michael, Michael-annulation, and oxa-Diels-Alder reactions of carbohydrate derivatives that afford polyoxy-functionalized piperidine derivatives bearing tetrasubstituted carbon at the 3-position of the piperidine ring are reported. Iminium ions generated from carbohydrate derivatives with amines were converted to enamines in situ, which acted as nucleophiles. As a result, substituents were introduced at the 3-position or both 2- and 3-positions of the piperidines bearing polyoxy groups. This strategy will be useful in drug discovery efforts.

Application of 388077-74-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 388077-74-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem