Category: 385425-15-0

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: C11H12INO, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 385425-15-0, Name is 1-(4-Iodophenyl)piperidin-2-one, molecular formula is C11H12INO. In a Patent, authors is ，once mentioned of 385425-15-0

The present invention relates to an improved process for the preparation of Apixaban and its intermediates.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 385425-15-0, help many people in the next few years.HPLC of Formula: C11H12INO

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23061N – PubChem

Chemistry is an experimental science, Product Details of 385425-15-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 385425-15-0, Name is 1-(4-Iodophenyl)piperidin-2-one

The present invention provides a method for preparing […] , the structure of the compounds of the formula (II) compound having a structure of the formula (III) is obtained by reacting the compound of formula (IV), then the compounds of the formula (IV) into […] structure, wherein the structure of the formula (II) by selecting the compounds of formula (III) the reaction of a compound of the structure, the compounds of formula (IV) structure, not only simplifies the preparation method of compound of formula (IV), and higher yield, further the total yield is greatly improved. (by machine translation)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Product Details of 385425-15-0, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 385425-15-0, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23064N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, name: 1-(4-Iodophenyl)piperidin-2-one, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 385425-15-0, Name is 1-(4-Iodophenyl)piperidin-2-one, molecular formula is C11H12INO. In a Patent, authors is ，once mentioned of 385425-15-0

Disclosed are a compound of formula (I), a tautomer, an optical isomer or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the above-mentioned compounds. The above-mentioned compounds have the activity of inhibiting Xa factor positive effect, and can be used for the preparation of a medicament for preventing and/or treating diseases inhibiting Xa factor positive effect in case of low bleeding risk.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. name: 1-(4-Iodophenyl)piperidin-2-one

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23074N – PubChem

385425-15-0, 1-(4-Iodophenyl)piperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under room temperature, will be sequentially 1 – (piperidin-2-oxo-1-yl) – 4-iodophenylamino (2.5 g, 8.3 mmol), 1 – (3-fluoro-4-ethoxy phenyl) – 7-oxo -4, 5, 6, 7-tetrahydro -1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid ethyl ester (2.4 g, 6.9 mmol) and potassium carbonate (2.1 g, 15.1 mmol) by adding DMSO in (35 ml). Under the protection of nitrogen is added in the mixture of the obtained CuI (650 mg, 3.4 mmol) and 1,10-phenanthrene (613 mg, 3.4 mmol). The obtained mixture is heated to 120 C, reaction 12 hours. After the completion of the reaction, the obtained cooling to room temperature the mixture, adding water. The resulting mixture is extracted with ethyl acetate. The resulting organic phase is concentrated under reduced pressure to obtain crude products. Crude product is purified by silica gel column chromatography (PE:EA=1:1) to obtain 1.0 g (yield: 26.7%) of the product., 385425-15-0

The synthetic route of 385425-15-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CSPC Weisheng Pharmaceutical Technology (Shijiahuang) Co., Ltd.; Shi, Ying; Gao, Qingzhi; Mi, Yi; Wang, Xuliang; (129 pag.)CN105384739; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.385425-15-0,1-(4-Iodophenyl)piperidin-2-one,as a common compound, the synthetic route is as follows.

Example 52 1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid (61). A solution of 1-(4-methoxy-phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester (50, 2.0 g, 6.4 mmol), 1-(4-iodo-phenyl)-piperidin-2-one (60, 2.5 g, 8.3 mmol, 1.3 equiv), and K2CO3 (325 mesh powder, 1.80 g, 12.8 mmol, 2.0 equiv) in DMSO (35 mL) was degassed three times under a steady nitrogen stream before being treated with CuI (244 mg, 1.3 mmol, 20% equiv) and 8-hydroxyquinoline (189 mg, 1.3 mmol, 20% equiv) under N2. The resulting reaction mixture was subsequently degassed three times again before being warmed up to 125 C. for 10 h. When HPLC showed the coupling reaction was complete, the reaction mixture was cooled down to 5-10 C. before being treated with 14% NH4OH aqueous solution (30 mL) and ethyl acetate (30 mL) at 5-10 C. with good stirring. The mixture was stirred for an additional 1 h at 5-10 C. The mixture was filtered through a Celite bed and the Celite bed was washed with water (2*10 mL). The two layers of the filtrates were separated, and the aqueous layer was acidified by 1 N aqueous HCl solution to pH=4. The mixture was subsequently stirred at 5-10 C. for an additional 1 h. The solids were collected by filtration, washed with water (2*5 mL), and dried in vacuo at 40-45 C. for 12 h to afford the crude desired 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid (61, 2.0 g, 2.95 g theoretical, 68%), which was found to be pure enough to do the following reaction without further purification. For 61, CIMS m/z 461 (M++H, C25H24N4O5)., 385425-15-0

As the paragraph descriping shows that 385425-15-0 is playing an increasingly important role.

Reference£º
Patent; Zhou, Jiacheng; Oh, Lynette M.; Ma, Philip; Li, Hui-Yin; Confalone, Pasquale; US2003/181466; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem