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Various 2-thiopyrimidine derivatives have been synthesized by an efficient, one-pot reaction of functionalized amines with either 4-isothiocyanato-4- methyl-2-pentanone or 3-isothiocyanatobutanal. All the synthesized compounds were fully characterized by elemental analysis (CHN), FT-IR, 1H NMR, and mass spectral data. One of the compounds, 7,7,8a-trimethyl-hexahydro- thiazolo[3,2-c]pyrimidine-5-thione (17) showed good anti-inflammatory (37.4% at 100 mg/kg p.o.) and analgesic activity (75% at 100 mg/kg p.o.). 7-(1-Mercapto-3,3,4a-trimethyl-4,4a,5,9b-tetrahydro-3H-pyrido[4,3-b]indol-7-yl) -3,3,4a-trimethyl-3,4,4a,5-tetrahydro-benzo[4,5]imidazo[1,2-c] pyrimidine-1-thiol (3) showed moderate activity against CDK-1 (IC50 = 5 muM). The other compounds showed moderate anti-inflammatory (5-20%), analgesic (25-75%) and protein kinase (CDK-5, GSK-3) inhibitory activities (IC50 > 10 muM).

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H8569N – PubChem

 

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 36768-62-4 is helpful to your research. HPLC of Formula: C9H20N2

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 36768-62-4, name is 4-Amino-2,2,6,6-tetramethylpiperidine, introducing its new discovery. HPLC of Formula: C9H20N2

Tris[2-hydroxy-3-(2,2,6,6-tetramethyl-4-piperidylamino)propyl] isocyanurate is useful as a light stabilizer for organic materials. A composition comprising an organic material and the isocyanurate is stable against light and also excellent in heat resistance. The isocyanurate can be produced by the reaction between tris(2,3-epoxypropyl) isocyanurate and 4-amino-2,2,6,6-tetramethylpiperidine.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 36768-62-4 is helpful to your research. HPLC of Formula: C9H20N2

Reference:
Piperidine – Wikipedia,
Piperidine | C5H8585N – PubChem

 

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The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 36768-62-4 is helpful to your research. Synthetic Route of 36768-62-4

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Poly-bis-triazinylimides of the formula STR1 are prepared from bis-(2,4-dichloro-1,3,5-triazin-6-yl)imides and polyalkylpiperidylamines. They are used as light stabilizers for polymers.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H8731N – PubChem

 

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Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 36768-62-4. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 36768-62-4

Reactions of 5-nitrospiro[benzimidazole-2,1′-cyclohexane] 1,3-dioxide with aliphatic amines and sodium hydroxide resulted in removal of one N-oxide oxygen atom and formation of 4-alkylamino- or 4-hydroxy-substituted 5-nitrospiro[benzimidazole-2,1′-cyclohexane] 1-oxides, respectively. The title compound reacted with ammonia and methylamine in the presence of MnO2 with conservation of both N-oxide moieties, and the products were 4-amino- and 4-methylamino-5-nitrospiro[benzimidazole-2,1′-cyclohexane] 1,3-dioxides. The reactions with aromatic amines were accompanied by removal of both N-oxide oxygen atoms with formation of N-aryl-5-nitrospiro[benzimidazole-2,1′- cyclohexane]-4-amines. In the reactions of 5-nitrospiro- [benzimidazole-2,1′- cyclohexane] 1,3-dioxide with sodium azide and aromatic amine hydrochlorides nucleophilic replacement of the 5-nitro group by azido or arylamino occurred, in the first case both N-oxide fragments being conserved. The reactions with aromatic amine hydrochlorides afforded N-aryl-5-nitrospiro[benzimidazole- 2,1′-cyclohexan]-4-amine 1-oxides. Treatment of 5-nitrospiro[benzimidazole-2,1′- cyclohexane] 1,3-dioxide with sodium cyanide led to the formation of 5-oxo-3,5-dihydrospiro[benzimidazole-2,1′-cyclohexane]-4- carbonitrile 1-oxide. Pleiades Publishing, Ltd., 2012.

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Piperidine – Wikipedia,
Piperidine | C5H8721N – PubChem

 

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Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 36768-62-4. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 36768-62-4

A novel water-soluble macromolecular light stabilizer was synthesized by grafting 2-chloro-4,6-bis-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,3,5- triazine onto polyvinylamine. The intermediate 2-chloro-4,6-bis-[(2,2,6,6- tetramethylpiperidin-4-yl)amino]-1,3,5-triazine and the obtained macromolecular light stabilizer were characterized by 1H NMR, HRMS, IR and UV spectroscopy. Cotton fabrics dyed with C.I. Reactive Yellow 145, C.I. Reactive Red 195 and C.I. Reactive Blue 19 were finished with the macromolecular light stabilizer, and the lightfastness of the dyes was tested. The results showed that the lightfastness of the reactive dyes was improved by 0.5-1.0 grade after being finished and the macromolecular light stabilizer exhibited good wash fastness and thermal stability.

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Piperidine – Wikipedia,
Piperidine | C5H8843N – PubChem

 

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Related Products of 36768-62-4, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 36768-62-4, name is 4-Amino-2,2,6,6-tetramethylpiperidine. In an article,Which mentioned a new discovery about 36768-62-4

Several small molecule CD4 mimics have been reported previously as HIV-1 entry inhibitors, which block the interaction between the Phe43 cavity of HIV-1 gp120 and the host CD4. Known CD4 mimics such as NBD-556 possess significant anti-HIV activity but are less soluble in water, perhaps due to their hydrophobic aromatic ring-containing structures. Compounds with a pyridinyl group in place of the phenyl group in these molecules have been designed and synthesized in an attempt to increase the hydrophilicity. Some of these new CD4 mimics, containing a tetramethylpiperidine ring show significantly higher water solubility than NBD-556 and have high anti-HIV activity and synergistic anti-HIV activity with a neutralizing antibody. The CD4 mimic that has a cyclohexylpiperidine ring and a 6-fluoropyridin-3-yl ring has high anti-HIV activity and no significant cytotoxicity. The present results will be useful in the future design and development of novel soluble-type molecule CD4 mimics.

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Piperidine – Wikipedia,
Piperidine | C5H8712N – PubChem

 

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The present invention relates to 1 H-pyrazolo[3,4-b]pyridine compounds of the formula (I) in which R 1, R2, R3 and R4 are defined as indicated below. The compounds of the formula I are protein kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

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Piperidine – Wikipedia,
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A new class of low-cost, easily-synthesizable and modifiable chiral amine bis(phenolate) ligand (L), its chiral boron complex (LB), and five different salen groups (1-(3-Aminopropyl) imidazole (LB1), N,N-Diethyl-p-phenylenediamine (LB2), 2-Picolylamine (LB3), 4?-Aminoacetophenone (LB4), and 4-Amino-2,2,6,6-tetramethyl piperidine (LB5)) containing chiral boron complexes were synthesized in this study. These newly synthesized chiral compounds were fully characterized by 1H and 13C NMR, FT-IR, UV?Vis, and LC-MS/MS spectroscopy, melting point, elemental analysis, and cyclic voltammetry techniques. The in vitro antibacterial activity of the synthesized different chiral boron complexes was tested against four pathogenic bacteria strains using the resazurin-based broth microdilution method, and the MIC values of each boron complex were determined. Based on the overall results, the N, N-Diethyl-p-phenylenediamine group containing chiral boron complex (LB2) showed the highest activity against all bacterial strains, with the lowest MIC value of 4 mug/mL which is nearly in the range of values for commercial antibacterial drugs.

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Piperidine – Wikipedia,
Piperidine | C5H8854N – PubChem

 

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Process for the preparation of modified zinc oxide nanoparticles, which comprises reacting zinc oxide nanoparticles, which are dissolved in a solvent, in the presence of ammonia or amines with a tetraalkyl orthosilicate and optionally with an organosilane, with the proviso that the reaction takes place at a content of less than 5% by weight of water, based on the total amount of solvent and water. Modified zinc oxide nanoparticles which have Si?O-alkyl groups and are soluble in organic solvents, obtainable by this process for the preparation. Liquid or solid formulations which comprise modified ZnO nanoparticles. Inanimate organic materials, for example plastics or coatings, which comprise modified ZnO nanoparticles. Method of stabilizing inanimate organic materials against the effect of light, free radicals or heat, where modified ZnO nanoparticles, which optionally comprise UV absorbers and/or stabilizers as further additives, are added to the materials.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H8726N – PubChem

 

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Reference of 36768-62-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.36768-62-4, Name is 4-Amino-2,2,6,6-tetramethylpiperidine, molecular formula is C9H20N2. In a Article,once mentioned of 36768-62-4

Two zinc phosphates (ZnPO), [H2(N2C9H 20)]·[Zn(H2PO4)4] (I) and [H2(N2C9H20)]2· [Zn2(HPO4)3(H2PO4) 2]·H2O (II), are synthesized under hydrothermal conditions using 4-amino-2.2.6.6-tetramethylpiperidine as organic template. I crystallizes in P1 space group with a=8.7398(3)A, b=9.0417(3)A, c=15.3822(1)A, alpha=92.57(1), beta=89.76(1), gamma=102.16(2), V=1187.1(1)A3 and Z=2. Its structure, refined to R=0.029 and Rw=0.076 for 4279 independent reflections, consists of [Zn(H2PO4)4]2- clusters held together through strong hydrogen bonds to form pseudo-layers between which the doubly protonated amine molecules are inserted. II is monoclinic, C2, with a=27.57(2)A, b=9.745(5)A, c=14.08(1)A, beta=103.72(5), V=3675(4)A3 and Z=4 (R=0.079, Rw=0.268, 2477 independent reflections). The structure of II consists of ?[Zn2(HPO 4)3(H2PO4)2] 4- inorganic (2D) layers built up from vertex-sharing [ZnO 4] and [(H2/H)PO4] tetrahedra. Organic cations and water molecules ensure the connection between these layers via hydrogen bonds. It is shown that numerous (1D), (2D), e.g., [H2(N 2C9H20)]2·[Zn 2(HPO4)3(H2PO4) 2]·H2O, and (3D) (ZnPO) result from the condensation of the [Zn(H2PO4)4]2- clusters.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H8573N – PubChem