Category: 352673-16-6

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A series of caspase inhibitors containing gamma-amino acid moiety have been synthesized. A systemic study on their structure-activity relationship of anti-apoptotic cellular activity is presented. These efforts led to the discovery of compound 20o as a potent caspase inhibitor, which demonstrated preclinical ameliorating total bilirubin efficacy with a significantly improved pharmacokinetic profile.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H21688N – PubChem

352673-16-6, 1-(2-Chlorobenzoyl)piperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of1-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)piperidine-4-carboxylic acid(900.00 mg, 2.71 mmol, 1.05eq) and HOBt (488.23 mg, 3.61 mmol, 1.40eq) in DCM (100.00 mL) was added EDCI (692.68 mg, 3.61 mmol, 1.40eq) . The reaction mixture was stirred for 15 min, at which time a solution of(3S)-tert-butyl 3-amino-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy) pentanoate(911.00 mg, 2.58 mmol, 1.00eq) and NMM (783.19 mg, 7.74 mmol, 851.29 uL, 3.00eq) in DCM (100.00 mL) was added and then the mixture was stirred for an additional 60 h at 25 C . The solution was diluted with DCM (100 mL) and washed with saturated aqueous sodium hydrogen carbonate (2 * 50 mL), saturated aqueous sodium chloride (1*100 mL), dried (MgSO4) and concentrated under reduced pressure. The residue was purified by flash silica gel chromatography (ISCO; 12 g SepaFlash Silica Flash Column, Eluent of 0~30%EtOAc/Petroleum ether gradient 36 mL/min) to give(3S)-tert-butyl 3-(1-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)piperidine- 4-carboxamido)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate(16)(1.24 g, 1.71 mmol, 66% yield) as a yellow oil., 352673-16-6

352673-16-6 1-(2-Chlorobenzoyl)piperidine-4-carboxylic acid 778084, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Mou, Jianfeng; Wu, Songliang; Luo, Zhi; Guo, Fengying; He, Haiying; Wang, Jianhua; Lin, Fusen; Guo, Fengxun; Sun, Jianping; Shen, Liang; Zeng, Minggao; Wang, Chuan; Xu, Deming; Gu, Zhengxian; Tian, Xin; Zhang, Aiming; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Li, Jian; Chen, Shuhui; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1874 – 1878;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem