Category: 3518-83-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.

Example 2 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene 6-Methoxy-2-(4-methoxyphenyl)-3-(4-hydroxybenzoyl)benzo[b]thiophene (1.17 g, 3.00 mmol), 4-hydroxy-1-ethylpiperidine (775 mg, 6.00 mmol), triphenylphosphine (1.57 g, 6.00 mmol), and DEAD (6.00 mmol) were converted to product by the procedure of Example 1 to give 827 mg of the title compound. Yield: 55%. MS(FD) 501(M+). EA calculated for C30 H31 NO4 S: C, 71.83; H, 6.23; N, 2.79. Found: C, 71.61; H, 5.94; N, 2.69.

3518-83-0, 3518-83-0 N-Ethyl-4-hydroxypiperidine 77056, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Eli Lilly and Company; US6060488; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.

N-Ethyl-4-hydroxypiperidine (3 g, 23.22 mmol) was dissolved in 20 mL of dry THF, TEA was added, and methanesulfonyl chloride (1.98 mL, 25.54 mmol) was slowly added dropwise under ice-cooling, and stirred at room temperature until the reaction was completed. 40 mL of water was added and ethyl acetate (3*50 mL) was used for extraction. The combined organic layer was washed successively with water (3*30 mL) and saturated NaCl solution (50 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed under reduced pressure, and the residue was isolated and purified by flash column chromatography (petroleum ether / ethyl acetate = 4/1, v / v) to give the product 4.0g, yield 81.2%. MS (ESI, m/z): 208(M +H)+., 3518-83-0

3518-83-0 N-Ethyl-4-hydroxypiperidine 77056, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; JIANG, Hualiang; LIU, Hong; GENG, Meiyu; ZHENG, Mingyue; AI, Jing; WANG, Yulan; WU, Xiaowei; LI, Shuangjie; PENG, Xia; LI, Chunpu; CHEN, Kaixian; WANG, Bao; (72 pag.)EP3470415; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3518-83-0, N-Ethyl-4-hydroxypiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-hydroxy-N-ethylpiperidine (267mg, 2.0 mmol) inTHF (5.0 mE) at RT was added NaH(60%w/w, 91 mg, 2.3 mmol) with stirring. The reaction mixturewas stirred at RT under nitrogen for 45 minutes. To the reac-tion mixture was then added 3-(4-chloro-6-methyl-2-pyrim-idinyl)-i-(3,4-dichlorophenyl)guanidine (4) (166 mg, 0.5mmol). The reaction mixture was stirred at RT for 5 hours and then heated to 90 C. for 18 hrs. The reaction mixture was cooled, poured into ice-water mixture and extracted with CH2C12 (2×25 mE). The CH2C12 layerwas washedwith waterand dried (Na2504), filtered and concentrated in vacuo toyield crude compound (200 mg, 94.8%). The crude com-pound was purified by column chromatography several times(silica, eluent, mixture ofCH2C12:MeOH:NH4OH in the ratio400: 50:2 respectively) to obtain the title compound (25) (20mg, 9%) as a solid. HPEC (254 nm): Method 3, Rt 2.89 miMS (ESI) mlz 425.3 [M+H].

3518-83-0, 3518-83-0 N-Ethyl-4-hydroxypiperidine 77056, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Curtana Pharmaceuticals, Inc.; BEATON, Graham; TUCCI, Fabio; RAVULA, Satheesh B.; WANG, Hua-Yu; (104 pag.)US2016/237069; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3518-83-0, N-Ethyl-4-hydroxypiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene 6-Methoxy-2-(4-methoxyphenyl)-3-(4-hydroxybenzoyl)benzo[b]thiophene (1.17 g, 3.00 mmol), 4-hydroxy-1-ethylpiperidine (775 mg, 6.00 mmol), triphenylphosphine (1.57 g, 6.00 mmol), and DEAD (6.00 mmol) were converted to product by the procedure of Example 1 to give 827 mg of the title compound. Yield: 55%. MS(FD) 501(M+). EA calculated for C30H31NO4S: C, 71.83; H, 6.23; N, 2.79. Found: C, 71.61; H, 5.94; N, 2.69.

3518-83-0, As the paragraph descriping shows that 3518-83-0 is playing an increasingly important role.

Reference：
Patent; ELI LILLY AND COMPANY; EP905132; (1999); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.

Example 11 In a 200-ml three-necked flask equipped with dropping funnel, thermometer and reflux condenser, there were placed 4.80 g of N-ethyl-4-hydroxypiperidine, 3.23 g of pyridine and 50 ml of benzene, and 11.60 g of farnesylacetyl chloride was added dropwise under reflux. After completion of the dropping, the mixture was refluxed for a subsequent 2 hour period and then cooled. Addition of 30 ml of 20% aqueous solution of sodium hydroxide, stirring, phase separation and silica gel column chromatography of the upper layer yielded 2.4 g of N-ethyl-4-farnesylacetoxy-piperidine as a pale-yellow liquid.

3518-83-0, The synthetic route of 3518-83-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Kuraray Co., Ltd.; US4289786; (1981); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3518-83-0, N-Ethyl-4-hydroxypiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-ethyl piperidin-4-ol(200 mg1.55 mmol) was added to dry THF (10 mL) and the mixture was cooled to 0oC, then NaH (60%, 124 mg3.1 mmol) was added slowly. The mixture was stirred at 0oC for 0.5 h and then 2,5-dichloropyrodazine(231 mg1.55 mmol) was added and stirred overnight. The reaction was quenched with iced water and extracted with DCM, the organic layer was washed with brine, dried and concentrated to afford compound 12(330 mg, white solid).LC-MS: 242.1(M+H).

3518-83-0, The synthetic route of 3518-83-0 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Fu, Yan; Tang, Shuai; Su, Yi; Lan, Xiaojing; Ye, Yan; Zha, Chuantao; Li, Lei; Cao, Jianhua; Chen, Yi; Jiang, Lei; Huang, Ying; Ding, Jian; Geng, Meiyu; Huang, Min; Wan, Huixin; Bioorganic and Medicinal Chemistry Letters; vol. 27; 23; (2017); p. 5332 – 5336;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.

Add to the reaction flask1-ethylpiperidin-4-ol (1.0 g, 7.7 mmol), 2,5-dibromopyridine (2 g, 8.5 mmol)And dimethylsulfoxide (30 mL) were added sodium tert-butoxide (1.7 g, 15.4 mmol).The mixture was stirred at room temperature for 3 hours, water (30 mL) was added,Dichloromethane extraction (20 mL x 3) .The organic layers were combined,Washed with saturated brine (20 mL), dried over anhydrous sodium sulfate and the filtrate was concentrated in vacuo.The resulting residue was purified by column chromatography (DCM / MeOH = 10: 1)To give the title compound (702 mg, black solid) in 32% yield., 3518-83-0

As the paragraph descriping shows that 3518-83-0 is playing an increasingly important role.

Reference：
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3518-83-0, N-Ethyl-4-hydroxypiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add 20 mg of calcium hydride as a desiccant to a dry 10 ml reaction tube. Nitrogen is introduced to create an oxygen-free environment for the reaction system. Take 1-ethylpiperidin-4-ol (154 mg, 1.2 mmol), Alizarin yellow R (5 mol%) was dissolved in 1.5 ml of acetonitrile and syringe was inserted into the reaction tube. After stirring for 20 minutes, 2-naphthalenesulfonyl chloride (227 mg, 1.0 mmol) was dissolved in 1.5 ml of acetonitrile and injected into the reaction system with a syringe. The reaction was carried out under a normal temperature of 30 W for 24 hours. The organic layer was extracted with ethyl acetate (20 mL×3×). The solvent was evaporated under reduced pressure, and the product was obtained by flash column chromatography to afford 232 mg (yield: 80%).

3518-83-0, As the paragraph descriping shows that 3518-83-0 is playing an increasingly important role.

Reference：
Patent; Northwest Normal University; Fu Ying; Shi Chunzhao; Xu Qinshan; (8 pag.)CN110204465; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem