Category: 334618-07-4

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-Piperidin-3-amine dihydrochloride( cas:334618-07-4 ) is researched.Reference of (S)-Piperidin-3-amine dihydrochloride.Ishikawa, Minoru; Hiraiwa, Yukiko; Kubota, Dai; Tsushima, Masaki; Watanabe, Takashi; Murakami, Shoichi; Ouchi, Shokichi; Ajito, Keiichi published the article 《Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part III: Synthesis of potent antagonists with αvβ3/αIIbβ3 dual activity and improved water solubility》 about this compound( cas:334618-07-4 ) in Bioorganic & Medicinal Chemistry. Keywords: pharmacophore integrin aminopiperidine derivative SAR preparation. Let’s learn more about this compound (cas:334618-07-4).

In order to optimize our novel integrin αvβ3/αIIbβ3 dual antagonists, spatial screening at the N-terminus was performed. The αvβ3 antagonistic activity varied depending on the space that was occupied by the N-terminus, but high potency against αIIbβ3 was well maintained. The (3S)-aminopiperidine analog had the strongest activity against αvβ3, and the S isomer at piperidine was more potent than the R isomer. Compounds selected on the basis of SAR anal. of a novel lead compound showed acceptable early absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles and sufficient water solubility for use as infusion drugs. Docking studies with the αvβ3 receptor were performed to confirm the SAR findings.

This compound((S)-Piperidin-3-amine dihydrochloride)Reference of (S)-Piperidin-3-amine dihydrochloride was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Electric Literature of C5H14Cl2N2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (S)-Piperidin-3-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 334618-07-4, about Exploration of Chiral Organic-Inorganic Hybrid Semiconducting Lead Halides. Author is Peng, Yu; Yao, Yunpeng; Li, Lina; Liu, Xitao; Zhang, Xinyuan; Wu, Zhenyue; Wang, Sasa; Ji, Chengmin; Zhang, Weichuan; Luo, Junhua.

Organic-inorganic lead halides have recently emerged as promising alternatives to conventional optoelectronic materials, considering their intriguing phys. properties. However, organic-inorganic lead halides featuring chirality are seldom explored. Here, a pair of enantiomorphic organic-inorganic hybrid semiconducting lead halides, (R-C5H14N2)PbBr4 (1R) and (S-C5H14N2)PbBr4 (2S), were successfully obtained with the templating of chiral amines. These compounds adopt distinct one-dimensional infinite quantum helixes formed by edge-shared transformative lead bromide octahedra. Notably, 1R and 2S present mirror CD signals due to the chirality transfer of the enantiopure amines. Furthermore, 1R and 2S exhibit phase-matchable quadratic nonlinear response and typical semiconducting behaviors. This work highlights the potential of lead halides as a new kind of chiral semiconducting materials in spintronic and chiral optical applications.

《Exploration of Chiral Organic-Inorganic Hybrid Semiconducting Lead Halides》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((S)-Piperidin-3-amine dihydrochloride)Electric Literature of C5H14Cl2N2.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Angewandte Chemie, International Edition called Chirality-Dependent Second-Order Nonlinear Optical Effect in 1D Organic-Inorganic Hybrid Perovskite Bulk Single Crystal, Author is Fu, Dongying; Xin, Jianli; He, Yueyue; Wu, Shichao; Zhang, Xinyuan; Zhang, Xian-Ming; Luo, Junhua, which mentions a compound: 334618-07-4, SMILESS is Cl.Cl.N[C@H]1CCCNC1, Molecular C5H14Cl2N2, Name: (S)-Piperidin-3-amine dihydrochloride.

The introduction of chirality into organic-inorganic hybrid perovskites (OIHPs) is expected to achieve excellent photoelec. and nonlinear materials related to CD. Owing to the existence of asym. center and intrinsic chirality in the chiral OIHPs, the different efficiencies of second harmonic generation (SHG) signal occurs when the circularly polarized light (CPL) with different phases passes through the chiral crystal, which is defined as second harmonic generation CD (SHG-CD). Here, the SHG-CD effect is developed in bulk single crystals of chiral one-dimensional (1D) [(R/S)-3-aminopiperidine]PbI4. It is the first time that CPL is distinguished using chirality-dependent SHG-CD effect in OIHPs bulk single crystals. Such SHG-CD technol. extends the detection range to near IR region (NIR). In this way, the anisotropy factor (gSHG-CD) through SHG-CD signal is as high as 0.21.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Quality Control of (S)-Piperidin-3-amine dihydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (S)-Piperidin-3-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 334618-07-4, about A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Author is Shi, Yihui; Park, Jaehyeon; Lagisetti, Chandraiah; Zhou, Wei; Sambucetti, Lidia C.; Webb, Thomas R..

The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer. Compounds that modulate this process have recently been shown to target a specific vulnerability in tumors. We have developed a novel cell-based assay that specifically activates luciferase in cells exposed to SF3B1 targeted compounds, such as sudemycin D6. This assay was used to screen a combined collection of approved drugs and bioactive compounds This screening approach identified several active hits, the most potent of which were CGP-74514A and aminopurvalanol A, both have been reported to be cyclin-dependent kinases (CDKs) inhibitors. We found that these compounds, and their analogs, show significant cdc2-like kinase (CLK) inhibition and clear structure-activity relationships (SAR) at CLKs. We prepared a set of analogs and were able to ‘dial out’ the CDK activity and simultaneously developed CLK inhibitors with low nanomolar activity. Thus, we have demonstrated the utility of our exon-skipping assay and identified new mols. that exhibit potency and selectivity for CLK, as well as some structurally related dual CLK/CDK inhibitors.

There is still a lot of research devoted to this compound(SMILES：Cl.Cl.N[C@H]1CCCNC1)Quality Control of (S)-Piperidin-3-amine dihydrochloride, and with the development of science, more effects of this compound(334618-07-4) can be discovered.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Lai, Zeng-Wei; Li, Chunhong; Liu, Jun; Kong, Lingyi; Wen, Xiaoan; Sun, Hongbin published an article about the compound: (S)-Piperidin-3-amine dihydrochloride( cas:334618-07-4,SMILESS:Cl.Cl.N[C@H]1CCCNC1 ).COA of Formula: C5H14Cl2N2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:334618-07-4) through the article.

Highly potent DPP-4 inhibitors have been identified by hybrid compound design based on linagliptin and alogliptin. The most promising compound I (IC50 = 0.31 nM) exhibited 8.5-fold and 2.5-fold more potent activity than that of alogliptin (IC50 = 2.63 nM) and linagliptin (IC50 = 0.77 nM), resp. Compound I had a good inhibition selectivity for DPP-4 over DPP-8/9 and thus was selected for further biol. evaluation, including oral glucose tolerance, plasma DPP-4 inhibitory activity, pharmacokinetic profile, acute toxicity and hERG inhibition. The assay results showed that I displayed significant in vivo glucose-lowering effect and low risk of toxicity. Further studies are expected to confirm I as a potential drug candidate for the treatment of type 2 diabetes.

From this literature《Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin》,we know some information about this compound(334618-07-4)COA of Formula: C5H14Cl2N2, but this is not all information, there are many literatures related to this compound(334618-07-4).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem