Category: 3298-16-6

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Product Details of 3298-16-6, Which mentioned a new discovery about 3298-16-6

A process for the preparation of five-membered or six-membered ring lactams from aliphatic alpha,omega-dinitriles has been developed. In the process an aliphatic alpha,omega-dinitrile is first converted to an ammonium salt of an omega-nitrile-carboxylic acid in aqueous solution using a catalyst having an aliphatic nitrilase (EC 3.5.5.7) activity, or a combination of nitrile hydratase (EC 4.2.1.84) and arnidase (EC 3.5.1.4) activities. The ammonium salt of the omega-nitrilecarboxylic acid is then converted directly to the corresponding lactam by hydrogenation in aqueous solution, without isolation of the intermediate omega-nitrilecarboxylic acid or omega-aminocarboxylic acid. When the aliphatic alpha,omega-dinitrile is also unsymmetrically substituted at the alpha-carbon atom, the nitrilase produces the omega-nitrilecarboxylic acid ammonium salt resulting from hydrolysis of the omega-nitrile group with greater than 98% regioselectivity, thereby producing only one of the two possible lactam products during the subsequent hydrogenation. A heat-treatment process to select for desirable regioselective nitrilase or nitrile hydratase activities while destroying undesirable activities is also provided.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H1625N – PubChem

 

Synthetic Route of 3298-16-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3298-16-6, Name is 5-Methylpiperidin-2-one, molecular formula is C6H11NO. In a Article£¬once mentioned of 3298-16-6

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

A series of novel carbazole-containing amides and ureas were synthesized. A structure?activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the desired pharmacokinetic/pharmacodynamic parameters and the results of efficacy studies in db/db mice, compound 50 was selected for further profiling.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H1624N – PubChem