Category: 32559-18-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32559-18-5,Methyl piperidine-2-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

1-(2-Oxo-2-thiophen-2-yl-acetyl)piperidine-2-carboxylic acid N’-(6-methyl-4-trifluoromethyl-pyridin-2-yl)-hydrazide A solution of methyl pipecolinate hydrochloride (7.2 g, 40 mmol) in dry DCM (100 mL) and TEA (8.3 g) was cooled to 0 C. The slurry was stirred for 1 h. Methyl oxalyl chloride was added. The mixture was stirred at 0 C. for 2 h. Water was added, and the organic phase was washed with a NaHCO3 solution, dried with MaSO4. Evaporation of the solvent and drying in vacuum gave a reddish oil; 9.1 g (99%); MS (m/z) 252 (M+Na).

32559-18-5, 32559-18-5 Methyl piperidine-2-carboxylate hydrochloride 13246231, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Sui, Zhihua; Macielag, Mark; Lanter, James; US2003/144262; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32559-18-5,Methyl piperidine-2-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Methyl pipecolinate hydrochloride (9.0 g, 50 mmol) was mixed with pyridine-2- carbaldehyde (5.4 g, 50 mmol) and triethylamine (5.05 g, 50 mmol) in dichloroethane (180 mL) at room temperature. Sodium triacetoxyborohydride (14.8 g, 70 mmol) was added in one portion. After the reaction mixture was stirred at room temperature for 1.5 h, saturated sodium carbonate was added. Then the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried with sodium sulfate, filtered and concentrated to give 10.9 g (93.6%) of the title compound as a pale brown [OIL. LH NMR (CDC13), 6] (ppm): 8.53 (d, 1H), 7.65 (td, 1H), 7.49 (d, 1H), 7.14 (t, 1H), 3.89 (d, 1H), 3.73 (s, 3H), 3. 68 (d, 1H), 3.25 (dd, 1H), 2.97 (m, 1H), 2.25 (m, [1H),] 1.85 (m, 2H), 1.30-1. 76 (m, 4H).

32559-18-5, The synthetic route of 32559-18-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14902; (2004); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32559-18-5, Methyl piperidine-2-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Piperidine-2-carboxamide. A mixture of methyl pipecolinate hydrochloride (15.0 g, 83 mmol, Aldrich) and 8% aqueous solution of ammonium hydroxide (150 mL) was stirred for 18 h at room temperature. The white precipitate was filtered and the filter cake was washed with water, and dried under vacuo to give the title compound. MS (ESI, pos. ion) m/z: 129 (M+1)., 32559-18-5

32559-18-5 Methyl piperidine-2-carboxylate hydrochloride 13246231, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Norman, Mark H.; Pettus, Liping H.; Wang, Xianghong; Zhu, Jiawang; US2006/58308; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32559-18-5, Methyl piperidine-2-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) N-Methylpiperidine-2-carboxamide.; To methyl pipecolinate hydrochloride (5.0 g, 28 mmol, Aldrich) was added methylamine (20 mL, 40 wt. % solution in H2O, Aldrich). The mixture was stirred at 25 C. for 18 h and then evaporated under reduced pressure. The residue was dried in vacuo to give the crude title compound, which was used in the next step without additional purification., 32559-18-5

The synthetic route of 32559-18-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Liao, Hongyu; Norman, Mark H.; Stec, Markian; Tamayo, Nuria; Wang, Xianghong; US2006/183745; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32559-18-5,Methyl piperidine-2-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

32559-18-5, A solution of methyl piperidine-2-carboxylate hydrochloride (5 g, 27 mmol, Aldrich) in NH4OH (100 mL) was stirred at RT for 4 h. Then, the mixture was concentrated in vacuo to give the title compound, which was used in the next step without purification. MS (ESI, positive ion) m/z: 129 (M+1).

As the paragraph descriping shows that 32559-18-5 is playing an increasingly important role.

Reference：
Patent; Gore, Vijay Keshav; Ma, Vu Van; Norman, Mark H.; Ognyanov, Vassil I.; Xi, Ning; US2006/84640; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32559-18-5, Methyl piperidine-2-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(a) Piperidine-2-carboxamide. A mixture of methyl pipecolinate hydrochloride (15.0 g, 83 mmol, Aldrich) and 8% aqueous solution of ammonium hydroxide (150 mL) was stirred for 18 h at room temperature. The white precipitate was filtered and the filter cake was washed with water, and dried under vacuo to give the title compound. MS (ESI, pos. ion) m/z: 129 (M+1).

32559-18-5, 32559-18-5 Methyl piperidine-2-carboxylate hydrochloride 13246231, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Norman, Mark H.; Pettus, Liping H.; Wang, Xianghong; Zhu, Jiawang; US2006/58308; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32559-18-5,Methyl piperidine-2-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,32559-18-5

A solution of methyl piperidine-2-carboxylate hydrochloride (5 g, 27 mmol, Aldrich) in NH4OH (100 mL) was stirred at RT for 4 h. Then, the mixture was concentrated in vacuo to give the title compound, which was used in the next step without purification. MS (ESI, positive ion) m/z: 129 (M+1).

As the paragraph descriping shows that 32559-18-5 is playing an increasingly important role.

Reference：
Patent; Gore, Vijay Keshav; Ma, Vu Van; Norman, Mark H.; Ognyanov, Vassil I.; Xi, Ning; US2006/84640; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32559-18-5, Methyl piperidine-2-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of methyl pipecolate hydrochloride (1 g, 5.57 mmol) in THF (10 ml) was added phenothiazine carbonyl chloride (1.457 g, 5.57 mmol) followed by diisopropylethylamine (2.02 ml, 11.68 mmol). The resulting solution was stirred for 16 h before being partitioned between ethyl acetate and aq. sat. NH4Cl. The organic layer was washed with brine, dried (MgSO4), filtered and evaporated. The residue was purified by flash chromatography (15% ethyl acetate in hexane) to afford the sub-title compound as a colorless oil which crystallized upon standing (1.823 g, 89%): 1H NMR (400 MHz, CDCl3) delta 1.13-1.48 (3H, m), 2.57-2.69 (2H, m), 2.16 (1H, m), 3.00 (1H, m), 3.74 (4H, s+m), 5.00 (1H, m), 7.11 (2H, t), 7.22-7.34 (4H, m), 7.76 (2H, d); 13C NMR (100 MHz, CDCl3) delta 21.3 (CH2), 24.8 (CH2), 27.3 (CH2), 44.9 (CH2), 52.5 (CH3), 55.9 (CH), 122.8 (CH), 125.5 (CH), 127.8 (CH), 128.0 (CH), 129.2 (C), 141.7 (C), 158.4 (C), 172.2 (C), 32559-18-5

As the paragraph descriping shows that 32559-18-5 is playing an increasingly important role.

Reference：
Patent; Randle, John C.R.; US2005/267101; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem