324769-06-4, 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Stage (ii): tert-Butyl 4-(4-methoxybenzylamino)-3,3-dimethylpiperidine-1-carboxylate tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate (3.3 g, 14.53 mmol, 1 eq) and 4-methoxybenzylamine (3.98 g, 29.07 mmol, 2 eq) were dissolved in dichloromethane (40 ml), and stirring was carried out for 2 h at RT. The reaction mixture was cooled to 0 C., and Na(OAc)3BH (9.24 g, 43.61 mmol, 3 eq) was added in portions. Then stirring was carried out for 16 h at RT. The reaction mixture was diluted with dichloromethane (150 ml), washed with water and sat. NaCl solution (in each case 100 ml), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (Alox neutral, 10% ethyl acetate in hexane) (colourless oil). Yield: 38% (1.948 g, 5.59 mmol).
324769-06-4, 324769-06-4 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-oxopiperidine 22278899, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; GRUENENTHAL GmbH; US2012/71461; (2012); A1;,
Piperidine – Wikipedia
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