Category: 32188-75-3

32188-75-3, 5-Nitro-2-(piperidin-1-yl)benzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Subsequently, ammonium chloride (1.6 g) and iron powder (8.4 g) were added to a mixed solvent of water (40 ml) and ethanol (120 ml) and the mixture was heated to 65 C. 5-Nitro-2-piperidinobenzonitrile (10 g) was added by portions over 20 min and the mixture was stirred at the refluxing temperature for 30 min. The reaction mixture was ice-cooled and the reaction solution was filtrated. The solvent was evaporated under reduced pressure. An aqueous sodium hydroxide solution was added and the mixture was extracted with toluene. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. Diisopropyl ether was added to the residue to allow crystallization and the crystals were recrystallized from a mixed solvent of ethyl acetate-n-hexane to give the title compound (8.3 g). melting point: 148-149 C. 1H-NMR (270 MHz, CDCl3)delta(ppm):1.50-1.59 (2H, m), 1.71-1.79 (4H, m), 2.96-3.04 (4H, m), 3.6 (2H, brs), 6.76-6.90 (3H, m).

32188-75-3, 32188-75-3 5-Nitro-2-(piperidin-1-yl)benzonitrile 4811199, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Ushio, Hiroyuki; Naito, Youichiro; Sugiyama, Naoki; Kawaguchi, Takafumi; Ohtsuki, Makio; Chiba, Kenji; US2003/203909; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32188-75-3, 5-Nitro-2-(piperidin-1-yl)benzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2; 2-(1-piperidinyl)-5-(amino)benzonitrile; The 2-(1-piperidinyl)-5-(nitro)benzonitrile (25 g, 108 mmol) was solubilized in methanol (400 ml). A spatula tip of Pd/C was added to the mixture and the crude was stirred for 16 hours under hydrogen atmosphere. The mixture was filtered on Celite, concentrated and the expected product was isolated by recrystallization in an equimolar volume of dichloromethane and cyclohexane. Yield: 87%

32188-75-3, As the paragraph descriping shows that 32188-75-3 is playing an increasingly important role.

Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32188-75-3,5-Nitro-2-(piperidin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.

The compound 5-nitro-2- (piperidin-1-yl) benzoic acid was subjected to reduction reaction by NaBH4 for 30 min, followed by 2.0 g of a yellow solid (Compound 11), 32188-75-3

32188-75-3 5-Nitro-2-(piperidin-1-yl)benzonitrile 4811199, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Long Yaqiu; Xu Zhongliang; Wang Heyao; Cai Mengxin; (31 pag.)CN106892871; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem