Category: 3202-33-3

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ HPLC of Formula: C11H15NO, Which mentioned a new discovery about 3202-33-3

NEW USE OF PYRIMIDINE – OR TRIAZINE- 2-CARBONITILES FOR TREATING DISEASES ASSOCIATED WITH CYSTEINE PROTEASE ACTIVITY AND NOVEL PYRIMIDINE-2-CARBONITILE DERIVATIVES

The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition, this invention also discloses processes for the preparation of such inhibitors.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 3202-33-3, help many people in the next few years.HPLC of Formula: C11H15NO

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H10701N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 3202-33-3, name is 4-Phenoxypiperidine, introducing its new discovery. COA of Formula: C11H15NO

Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides

(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structure-activity relationship (SAR) and to attempt the improvement of the ADME properties of the lead, a series of compounds were prepared and tested. Several derivatives showed low nanomolar activity both in the binding and in the functional assay. In a formalin-induced hyperalgesia model in mice, 6a and (4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimidazol-2- yl]-methanone (60a) were as active as besonprodil (2) after oral administration. A CoMS1A model was developed based on binding data of a series of indole- and benzimidazole-2-carboxamides.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 3202-33-3 is helpful to your research. COA of Formula: C11H15NO

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H10743N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3202-33-3,4-Phenoxypiperidine,as a common compound, the synthetic route is as follows.

To a solution of 4-phenoxypiperidine (500 mg, 2.82 mmol) in DMF (6 mL) was added K2CO3 (0.78 g, 5.64 mmol) and 2-bromoethanol (0.39 g, 3.1 mmol). The reaction mixture was heated to 50C and stirred at that temperature for 3 h. TLC showed most of the product. The reaction was poured into water and extracted with DCM (3 x 40 mL). The combined organics were washed with saturated aqueous NaCl (2 x 20 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with a gradient elution of DCM (95%) and MeOH (5%) to DCM (85%) and MeOH (15%) to provide 2-(4- phenoxypiperidin-1-yl)ethanol (260 mg, 1.17 mmol) as a yellow solid.

3202-33-3, 3202-33-3 4-Phenoxypiperidine 18878, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SUNOVION PHARMACEUTICALS INC.; HEFFERNAN, Michele L.R.; HARDY, Larry Wendell; BROWN, Scott P.; HERMAN, Lee W.; (180 pag.)WO2018/26371; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem