Category: 32018-96-5

Related Products of 32018-96-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.32018-96-5, Name is 1-Benzyl-4-methylpiperidin-3-one, molecular formula is C13H17NO. In a Patent，once mentioned of 32018-96-5

A method of treating or preventing atherosclerosis comprising administering a compound of the formula [image] wherein R1, R2 and R3 are as defined above.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Related Products of 32018-96-5, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 32018-96-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15121N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 1-Benzyl-4-methylpiperidin-3-one. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 32018-96-5

The invention discloses a method for supporting france for cloth starting material N – ((3 R, 4 R) – 4 – methyl – 1 – benzyl – 3 – piperidinyl) – N – methyl – 7 – paratoluene sulfonyl – 7 H – pyrrolo [2, 3 – D] pyrimidine – 4 – amine (I) synthetic method, specific steps are as follows: to 4 – methyl pyridine as the starting material, with the benzyl chloride undergo nucleophilic substitution by the 4 – methyl – 1 – phenylmethyl – pyridine hydrochloride, under the action of the sodium borohydride reduction reaction, borohydrite – oxidation reaction, hydroxy oxidation, the introduction of the reductive amination of the stereo selectivity of the two chiral center, through a readily available and inexpensive chiral acid (L – DTTA) splitting, to obtain optically pure intermediates (3 R, 4 R) – (1 – benzyl – 4 – methyl – piperidin – 3 – yl) – methylamine, and finally with the 4 – chloro pyrrolo pyrimidine condensation is obtained. The whole method raw materials are easy, simple operation, after treatment is easy, and the cost is low. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 1-Benzyl-4-methylpiperidin-3-one, you can also check out more blogs about32018-96-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15118N – PubChem

Related Products of 32018-96-5, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 32018-96-5, name is 1-Benzyl-4-methylpiperidin-3-one. In an article，Which mentioned a new discovery about 32018-96-5

The invention relates to a supporting france for Nepal intermediate new preparation method, and in particular relates to holds the law for Nepal intermediate (3R, 4R) – 1 – benzyl – N, 4 – dimethyl piperidine – 3 – amine dihydrochloride of the preparation method, in order to 1 – benzyl – 4 – methyl – 1, 2, 3, 6 – tetrahydropyridine as the starting material, through the one-step olefin oxidation cheng Tong II, after amine formation imine III after the with, the use of asymmetric reduction imine amine, removing the trans isomer by crystallization to obtain cis structure IV, finally using the chiral separation to obtain the final product (3R, 4R) – 1 – benzyl – N, 4 – dimethyl piperidine – 3 – amine dihydrochloride I. The preparation method of the innovation process, shortened the process step, greatly improve the yield of the asymmetric synthesis of compounds, to a solid foundation for industrial mass production. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.32018-96-5. In my other articles, you can also check out more blogs about 32018-96-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H15110N – PubChem

32018-96-5, 1-Benzyl-4-methylpiperidin-3-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method A: (1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine To a stirred solution of 1-benzyl-4-methyl-piperidin-3-one (2.3 grams, 11.5 mmol), prepared by the methods of Iorio, M. A. and Damia, G., Tetrahedron, 26, 5519 (1970) and Grieco et al., Journal of the American Chemical Society, 107, 1768 (1985), (modified using 5% methanol as a co-solvent), both references are incorporated by reference in their entirety, dissolved in 23 mL of 2 M methylamine in tetrahydrofuran was added 1.4 mL (23 mmol) of acetic acid and the resulting mixture stirred in a sealed tube for 16 hours at room temperature. Triacetoxy sodium borohydride (4.9 grams, 23 mmol) was added and the new mixture stirred at room temperature in a sealed tube for 24 h, at which time, the reaction was quenched upon addition of 1 N sodium hydroxide (50 mL). The reaction mixture was then extracted 3¡Á80 mL with ether, the combined ether layers dried over sodium sulfate (Na2SO4) and concentrated to dryness in vacuo affording 1.7 grams (69%) of the title compound as a white solid. LRMS: 219.1 (M+1).

32018-96-5, 32018-96-5 1-Benzyl-4-methylpiperidin-3-one 12084828, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BEALS, Channing Rodney; WOLDEMUSSIE, Elizabeth; GUKASYAN, Hovhannes John; MA, Jingwen; US2013/303557; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32018-96-5, 1-Benzyl-4-methylpiperidin-3-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Method A: (1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine To a stirred solution of 1-benzyl-4-methyl-piperidin-3-one (2.3 grams, 11.5 mmol), prepared by the methods of Iorio, M. A. and Damia, G., Tetrahedron, 26, 5519 (1970) and Grieco et al., Journal of the American Chemical Society, 107, 1768 (1985), (modified using 5% methanol as a co-solvent), both references are incorporated by reference in their entirety, dissolved in 23 mL of 2 M methylamine in tetrahydrofuran was added 1.4 mL (23 mmol) of acetic acid and the resulting mixture stirred in a sealed tube for 16 hours at room temperature. Triacetoxy sodium borohydride (4.9 grams, 23 mmol) was added and the new mixture stirred at room temperature in a sealed tube for 24 h, at which time, the reaction was quenched upon addition of 1 N sodium hydroxide (50 mL). The reaction mixture was then extracted 3¡Á80 mL with ether, the combined ether layers dried over sodium sulfate (Na2SO4) and concentrated to dryness in vacuo affording 1.7 grams (69%) of the title compound as a white solid. LRMS: 219.1 (M+1).

32018-96-5, 32018-96-5 1-Benzyl-4-methylpiperidin-3-one 12084828, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BEALS, Channing Rodney; WOLDEMUSSIE, Elizabeth; GUKASYAN, Hovhannes John; MA, Jingwen; US2013/303557; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32018-96-5,1-Benzyl-4-methylpiperidin-3-one,as a common compound, the synthetic route is as follows.

To a stirred solution of 1-benzyl-4-methyl-piperidin-3-one (2.3 grams, 11.5 mmol), prepared by the methods of lorio, M.A. and Damia, G., Tetrahedron, 26, 5519 (1970) and Grieco et aL, Journal of the American Chemical Society, 107. 1768 (1985), (modified using 5% methanol as a co-solvent), both references are incorporated by reference in their entirety, dissolved in 23 mL of 2 M methylamine in tetrahydrofuran was added 1.4 mL (23 mmol) of acetic acid and the resulting mixture stirred in a sealed tube for 16 hours at room temperature. Triacetoxy sodium borohydride (4.9 grams, 23 mmol) was added and the new mixture stirred at room temperature in a sealed tube for 24 h, at which time, the reaction was quenched upon addition of 1 N sodium hydroxide (50 mL). The reaction mixture was then extracted 3 x 80 ml_ with ether, the combined ether layers dried over sodium sulfate (Na2SO4) and concentrated to dryness in vacuo affording 1.7 grams (69%) of the title compound as a white solid. LRMS: 219.1 (M+1 )., 32018-96-5

32018-96-5 1-Benzyl-4-methylpiperidin-3-one 12084828, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER PRODUCTS INC.; WO2008/29237; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

32018-96-5, 1-Benzyl-4-methylpiperidin-3-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The TiCl4(0.2g, 1mmol), NEt3(0.15g, 1 . 5mmol) suspended 200 ml in toluene, then add 1-benzyl-4-methyl-3-ketone piperidine (20.3g, 100mmol), temperature control 35 C methylamine solution is added to the reaction solution (9.32g, 120mmol) reaction 4 hours, adding NaBH (OAC) 3 (0.32g, 1 . 5mmol), glacial acetic acid 2 ml, temperature control 35 C reaction, thin layer monitoring after the reaction is complete. Adding saturated salt water washing, anhydrous sodium sulfate for drying the organic phase, the organic phase concentrated, with residues 35% hydrochloric acid ethanol re-crystallization, to obtain (3R, 4R)-cis-1-benzyl-4-methyl-3-methylamino-piperidine dihydrochloride 17.2g, yield 85.0%, optical purity 99.0% (HPLC method)., 32018-96-5

32018-96-5 1-Benzyl-4-methylpiperidin-3-one 12084828, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Shandong Elohim Pharmaceutical Group Co., Ltd.; Liu, Xiaofeng; Sun, Yuanlong; Yang, Linlin; (12 pag.)CN105884781; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem