Category: 31251-28-2

Studies on bipiperidines. XXII. Electroreduction of symmetric bipyridines on different metals was written by Artemova, V. M.;Forostyan, Yu. N.;Govorukha, V. G.;Forostyan, E. I.. And the article was included in Elektrokhimiya in 1976.Application of 31251-28-2 The following contents are mentioned in the article:

The relation between the electroreduction degree of 2,2′-bipyridine (I) [366-18-7], 3,3′-bipyridine (II) [581-46-4], and 4,4′-bipyridine (III) [553-26-4] and the nature of the cathode metal was studied on Cu, Cd, Ti, Zr, Pb, Nb, and Ta. The I and III were easily reduced on all metals, II was reduced with difficulty only on Pb and Cd. From I and II resulted erythro- and threo-2,2′-piperidine and erythro- and threo-3,3′-bipiperidine, resp. From III were obtained 4,4′-bipiperidine [15336-72-8] and 4-(4-piperidyl)-1,2,5,6-tetrahydropyridine [50387-17-2]. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Application of 31251-28-2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Application of 31251-28-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

From bipyridines to tobacco alkaloids and related compounds was written by Plaquevent, Jean-Christophe;Chichaoui, Ilhame. And the article was included in Bulletin de la Societe Chimique de France in 1996.Formula: C10H14N2 The following contents are mentioned in the article:

Structural considerations led to the hypothesis that a chem. relationship could exist between pyridine and pyrrolidine alkaloids and experiments were carried out in order to establish a correlation between the two classes. Nicotine holds a central position in these studies and the main part of this work was devoted to the synthesis of nicotine starting from bipyridines. It was thus necessary to determine the conditions for selective reactions on one aromatic ring of bipyridines (N-methylation, N-oxidation and reduction of the heterocycle). A ring contraction procedure gave nicotine from 3,3′-bipyridine. Complementary studies yielded various isomers of piperidinylpyridines in a regiochem. controlled manner. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Formula: C10H14N2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Formula: C10H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Dependence of the inhibiting effect of bipyridines and their hydro-derivatives on configuration was written by Forostyan, Yu. N.. And the article was included in Zashchita Metallov in 1983.Category: piperidines The following contents are mentioned in the article:

The inhibiting effect of bipyridines and their hydroderivs. (concentration 0.1%) on corrosion of steel St3  [39296-41-8] in solutions of 15% H₂SO₄ at 22° and constant mixing was studied. With increasing number at H atoms in mols. of bipyridines, the corrosion inhibition coefficient and protection degree increased due to an increase in the ionization constant (i.e. increase in the amine basicity). The inhibiting effect of bipyridines was directly associated with their configuration. In bipyridine hydroderivs., ionization coefficients were different due to the mutual arrangement of amino groups in mols. The greater the distance between amino groups (adsorption centers) in the bipyridine hydroderiv. mol., the higher the basicity of the compound and, thus, the ionization constant, inhibiting coefficient, and protection degree. 4,4‘-Bipyridine  [553-26-4] and its hydroderivs. had the greatest inhibiting effect. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Category: piperidines).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Bipiperidines. XX. Determination of the basicity of some bipiperidines was written by Forostyan, Yu. N.;Koval’chuk, B. V.;Efimova, E. I.. And the article was included in Zhurnal Obshchei Khimii in 1973.Application of 31251-28-2 The following contents are mentioned in the article:

Basicity values, pKa1 and pKa2, were determined for 8 bipiperidines and 4 piperidylpyridines. The values decreased as the distance between the N atoms decreased. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Application of 31251-28-2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 31251-28-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D₄ receptor agonists was written by Wang, Xueqing;Bhatia, Pramila A.;Daanen, Jerome F.;Latsaw, Steve P.;Rohde, Jeffrey;Kolasa, Teodozyi;Hakeem, Ahmed A.;Matulenko, Mark A.;Nakane, Masaki;Uchic, Marie E.;Miller, Loan N.;Chang, Renjie;Moreland, Robert B.;Brioni, Jorge D.;Stewart, Andrew O.. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Electric Literature of C10H14N2 The following contents are mentioned in the article:

A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D₄ agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Electric Literature of C10H14N2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C10H14N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Regioselective reduction of bipyridines was written by Plaquevent, Jean Christophe;Chichaoui, Ilhame. And the article was included in Tetrahedron Letters in 1993.Product Details of 31251-28-2 The following contents are mentioned in the article:

A method for the specific reduction of bipyridines through the use of the N-oxo derivatives is described. E.g., oxidation of 2,4′-bipyridine by m-chloroperbenzoic acid gave the N-oxo derivative, which was hydrogenated (H₂, Pd) to give 38% piperidinylpyridine I. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Product Details of 31251-28-2).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Product Details of 31251-28-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Bipiperidines. VI. Reaction of hexahydrobipyridines with chloroformates was written by Forostyan, Yu. N.;Efimova, E. I.. And the article was included in Zhurnal Organicheskoi Khimii in 1971.Name: 3-(Piperidin-3-yl)pyridine The following contents are mentioned in the article:

ClCO2R (R = Me, Et, Pr, Bu, iso-Bu, PhCH2) acylated 1′,2′,3′,4′,5′,6′-hexahydro-2,2′-, 3,3′-, 4,4′-, and 2′,3-bipyridines at the N of the piperidine ring, forming the corresponding alkyl pyridylpiperidine-1-carboxylates. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Name: 3-(Piperidin-3-yl)pyridine).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Name: 3-(Piperidin-3-yl)pyridine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Neonicotine and isomeric pyridylpiperidines was written by Smith, C. R.. And the article was included in Journal of the American Chemical Society in 1931.Category: piperidines The following contents are mentioned in the article:

cf. C. A. 18, 2006. Details are given for the isolation of neonicotine (尾-pyridyl-伪-piperidine) (I) from the reaction product of C₅H₅N, Na and O; I b₇₇₅ 280-1掳 and yields a picrate, m. 213掳 (con.); this is probably not identical with nicotimine, isolated by Pictet and Rotschky (Ber. 34, 696(1901)) from the nicotine alkaloids. Reduction of I gives 伪,尾-dipiperidyl, b. 269-70掳. Reduction of 伪,尾-dipyridyl gives isoneonicotine (伪-pyridyl-尾-piperidine), b₇₆₀ 282掳, whose picrate m. 217-8掳 (corrected). 伪,伪-Pyridylpiperidyl, b₇₅₅ 265-6掳, whose picrate m. 187掳; the NO derivative is an oil. Isonicotine (纬,纬-pyridylpiperidine) b₇₆₀ 292掳; the picrate m. 215-8掳 (decomposition); the NO derivative m. 112掳. Nicotidine (尾,尾-pyridylpiperidine) b. 284-5掳; picrate m. about 206掳. 尾-Pyridyl-纬-piperidine yields a picrate, m. 240掳. The ease of reduction by Sn and HCl of the dipyridyls is in the order 纬,纬-, 尾,纬, 伪,伪- and 尾,尾, the first being the most easily reduced. This study involved multiple reactions and reactants, such as 3-(Piperidin-3-yl)pyridine (cas: 31251-28-2Category: piperidines).

3-(Piperidin-3-yl)pyridine (cas: 31251-28-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem