Category: 309956-78-3

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The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.

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Piperidine – Wikipedia,
Piperidine | C5H13403N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 309956-78-3, name is (R)-tert-Butyl piperidin-3-ylcarbamate, introducing its new discovery. Product Details of 309956-78-3

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1

A series of reversible inhibitors of lysine specific demethylase 1 (LSD1) with a 5-hydroxypyrazole scaffold have been developed from compound 7, which was identified from the patent literature. Surface plasmon resonance (SPR) and biochemical analysis showed it to be a reversible LSD1 inhibitor with an IC50 value of 0.23?muM. Optimisation of this compound by rational design afforded compounds with Kd values of <10?nM. In human THP-1 cells, these compounds were found to upregulate the expression of the surrogate cellular biomarker CD86. Compound 11p was found to have moderate oral bioavailability in mice suggesting its potential for use as an in vivo tool compound. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 309956-78-3 is helpful to your research. Product Details of 309956-78-3

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Piperidine – Wikipedia,
Piperidine | C5H13504N – PubChem

 

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Pyrimidine and three nitrogen azole compounds, its preparation and use (by machine translation)

The invention belongs to the field of medical technology, in particular to the formula I structure pyrimidine and three nitrogen azole compound and its pharmaceutically acceptable salt, and its preparation method, pharmaceutical compositions containing them, and they are used for the preparation of medicine for treating rheumatoid arthritis, psoriasis, organ rejection reaction and other autoimmune disease use of medicament. (by machine translation)

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Piperidine – Wikipedia,
Piperidine | C5H13426N – PubChem

 

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A synthetic […] intermediates (by machine translation)

The present invention provides a method for synthesizing an intermediate V. The method comprises: (a) allowing a compound I and a compound II to react while being heated in a solvent under an alkaline condition to obtain an intermediate III; and (b) the intermediate III reacting with a compound IV in the solvent under the alkaline condition to obtain the intermediate V. The intermediate V can be used to synthesize alogliptin.

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Piperidine – Wikipedia,
Piperidine | C5H13356N – PubChem

 

Electric Literature of 309956-78-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.309956-78-3, Name is (R)-tert-Butyl piperidin-3-ylcarbamate, molecular formula is C10H20N2O2. In a Patent£¬once mentioned of 309956-78-3

A synthetic […] intermediates (by machine translation)

The present invention provides a method for synthesizing an intermediate V. The method comprises: (a) allowing a compound I and a compound II to react while being heated in a solvent under an alkaline condition to obtain an intermediate III; and (b) the intermediate III reacting with a compound IV in the solvent under the alkaline condition to obtain the intermediate V. The intermediate V can be used to synthesize alogliptin.

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Piperidine – Wikipedia,
Piperidine | C5H13356N – PubChem

 

Related Products of 309956-78-3, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 309956-78-3, name is (R)-tert-Butyl piperidin-3-ylcarbamate. In an article£¬Which mentioned a new discovery about 309956-78-3

Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3)

The design, synthesis, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na+/H+ exchanger type 3 (NHE3) are described based on a hit from high-throughput screening (HTS). The chemical optimization resulted in the discovery of potent, selective, and orally bioavailable NHE3 inhibitors with 13d as best compound, showing high in vitro permeability and lacking CYP2D6 inhibition as main optimization parameters. Aligning 1-phenoxy-2-aminoindanes onto the X-ray structure of 13d then provided 3D-QSAR models for NHE3 inhibition capturing guidelines for optimization. These models showed good correlation coefficients and allowed for activity estimation. In silico ADMET models for Caco-2 permeability and CYP2D6 inhibition were also successfully applied for this series. Moreover, docking into the CYP2D6 X-ray structure provided a reliable alignment for 3D-QSAR models. Finally 13d, renamed as SAR197, was characterized in vitro and by in vivo pharmacokinetic (PK) and pharmacological studies to unveil its potential for reduction of obstructive sleep apneas.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.309956-78-3. In my other articles, you can also check out more blogs about 309956-78-3

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Piperidine – Wikipedia,
Piperidine | C5H13431N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, name: (R)-tert-Butyl piperidin-3-ylcarbamate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 309956-78-3, Name is (R)-tert-Butyl piperidin-3-ylcarbamate, molecular formula is C10H20N2O2. In a Patent, authors is £¬once mentioned of 309956-78-3

DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS

The instant invention relates to derivatives of formula (I) and their application in therapeutics

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Piperidine – Wikipedia,
Piperidine | C5H13428N – PubChem

 

Application of 309956-78-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.309956-78-3, Name is (R)-tert-Butyl piperidin-3-ylcarbamate, molecular formula is C10H20N2O2. In a Article£¬once mentioned of 309956-78-3

Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma

Harboring MYD88 L265P mutation triggers tumors growth through the activation of NF-kappaB by interleukin-1 receptor associated kinase 4 (IRAK4) in diffuse large B-cell lymphoma (DLBCL), highlighting IRAK4 as a therapeutic target for tumors driven by aberrant MYD88 signaling. Herein, we report the design, synthesis, and structure?activity relationships of imidazo[1,2-b]pyridazines as potent IRAK4 inhibitors. The representative compound 5 exhibited excellent IRAK4 potency (IRAK4 IC50 = 1.3 nM) and favorable kinase selectivity profile. It demonstrated cellular selectivity for activated B cell?like (ABC) subtype DLBCL with MYD88 L265P mutation in cytotoxicity assay. The kinase inhibitory efficiency of compound 5 was further validated by Western blot analysis of phosphorylation of IRAK4 and downstream signaling in OCI-LY10 and TMD8 cells. Besides, combination of compound 5 and BTK inhibitor ibrutinib synergistically reduced the viability of TMD8 cells. These results indicated that compound 5 could be a promising IRAK4 inhibitor for the treatment of mutant MYD88 DLBCL.

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Piperidine – Wikipedia,
Piperidine | C5H13470N – PubChem

 

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Polymorphs of a xanthine compound and its preparation method, use (by machine translation)

The invention relates to medicine field of chemical synthesis, in particular to compound 1 – [(5-fluoro -1,3-benzothiazole-2-yl) methyl] – 3-methyl-7 – (2-butyne-1-yl) – 8 – [(R) – 3-amino-piperidin-1-yl]-xanthine polymorphic form of the compound and its preparation method and its as the therapeutic drug, especially as inhibitors of dipeptidyl peptidase IV(DPP-IV) use. (by machine translation)

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Piperidine – Wikipedia,
Piperidine | C5H13386N – PubChem

 

Reference of 309956-78-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 309956-78-3, Name is (R)-tert-Butyl piperidin-3-ylcarbamate, molecular formula is C10H20N2O2. In a Patent£¬once mentioned of 309956-78-3

Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions

The present invention relates to bicyclic imidazole compounds of general formula wherein R1 to R3 and A are defined as in claims 1 to 8, the tautomers, the enantiomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

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Piperidine – Wikipedia,
Piperidine | C5H13334N – PubChem