Category: 3040-44-6

Related Products of 3040-44-6, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 3040-44-6, Name is 1-(2-Hydroxyethyl)piperidine,introducing its new discovery.

SUBSTITUTED 4- (INDAZOLYL) -1,4-DIHYDROPYRIDINES AND METHODS OF USE THEREOF

This invention relates to novel 4-(indazolyl)-1,4-dihydropyridine og the following formula (I) derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders

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Piperidine – Wikipedia,
Piperidine | C5H5155N – PubChem

 

Electric Literature of 3040-44-6, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 3040-44-6, name is 1-(2-Hydroxyethyl)piperidine. In an article£¬Which mentioned a new discovery about 3040-44-6

Novel fused pyrrolocarbazoles

The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.3040-44-6. In my other articles, you can also check out more blogs about 3040-44-6

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Piperidine – Wikipedia,
Piperidine | C5H5200N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3040-44-6,1-(2-Hydroxyethyl)piperidine,as a common compound, the synthetic route is as follows.

A mixture of 20 mg of 2-(4-bromophenyl)-l,3-benzoxazole-5-carbonitrile (INTERMEDIATE 7), 17 mg of 2-piperidin-l-ylethanol, and 8 mg of sodium hydride (60% dispersion in oil) in 1 mL of toluene was purged and flushed with argon. Tris(dibenzylideneacetone) dipalladium (3 mg) and racemic BINAP (3 mg) were added and the mixture was heated to 800C and stirred overnight at this temperature. The reaction mixture was cooled and added directly to a 1000-muM thin-layer chromatography plate, eluting with 4% isopropanol in CH2Cl2 to provide 3.4 mg (15%) of the title compound. Mass spectrum (ESI)348.3 (M+l). 1H NMR (500 MHz, CDCl3): delta 8.18 (d, J=8.5 Hz, 2H), 8.02 (s, IH), 7.63 (m, 2H), 7.05 (d,J=9 Hz, 2H), 4.26 (t, J=6 Hz, 2H), 3.48 (d, J=3Hz, IH), 2.88 (br t, J=5.5 Hz, 2H), 2.61 (m, 3H), 1.68 (m, 5H), 1.49 (m, IH)., 3040-44-6

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Reference£º
Patent; MERCK & CO., INC.; WO2007/70173; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3040-44-6,1-(2-Hydroxyethyl)piperidine,as a common compound, the synthetic route is as follows.

2) Synthesis of 5-phenyl-4-[2-(1-piperidyl)ethoxy]thieno[2,3-d]pyrimidine (Example 369) Sodium hydride (8 mg, 0.16 mmol) was suspended in dry THF (0.5 mL). To this was added 2-(1-piperidyl)ethanol (16 muL, 0.12 mmol) and the reaction stirred for 10 min until effervescence had ceased. Then 4-chloro-5-phenyl-thieno[2,3-d]pyrimidine (20 mg, 0.08 mmol) in dry THF (0.5 mL) was added and the reaction left to stir at room temperature for 72 hrs. The reaction mixture was diluted with water and extracted with DCM. The organic layers were concentrated and the residue purified by preparative TLC (eluent 10% MeOH in DCM) to give 5-phenyl-4-[2-(1-piperidyl)ethoxy]thieno[2,3-d]pyrimidine as a yellow oil (19.4 mg, 72%). LCMS RT=3.03 min. M+1=340., 3040-44-6

3040-44-6 1-(2-Hydroxyethyl)piperidine 18232, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Madge, David; Chan, Fiona; John, Derek Edward; Edwards, Simon D.; Blunt, Richard; Hartzoulakis, Basil; Brown, Lindsay; US2014/371203; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem