Category: 301221-57-8

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: C12H24N2O3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 301221-57-8, Name is tert-Butyl 4-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate, molecular formula is C12H24N2O3. In a Patent, authors is ，once mentioned of 301221-57-8

The present invention relates to 4-alkyl substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H20340N – PubChem

Related Products of 301221-57-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.301221-57-8, Name is tert-Butyl 4-(2-amino-1-hydroxyethyl)piperidine-1-carboxylate, molecular formula is C12H24N2O3. In a article，once mentioned of 301221-57-8

USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason it has gained increasing attention as a potential oncology target for small molecule inhibitors. Herein we describe the biophysical, biochemical, and computational approaches that led to the identification of 4-(2-aminopyridin-3-yl)phenol compounds described by Kategaya et al. (Nature 2017, 550, 534-538) as specific inhibitors of USP7. Fragment based lead discovery (FBLD) by NMR combined with virtual screening and re-mining of biochemical high-throughput screening (HTS) hits led to the discovery of a series of ligands that bind in the “palm” region of the catalytic domain of USP7 and inhibit its catalytic activity. These ligands were then optimized by structure-based design to yield cell-active molecules with reasonable physical properties. This discovery process not only involved multiple techniques working in concert but also illustrated a unique way in which hits from orthogonal screening approaches complemented each other for lead identification.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H20335N – PubChem