28936-94-9 | Heterocyclic Building Blocks-piperidine

Sep 2021 News Some scientific research about 28936-94-9

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. COA of Formula: C14H17N3O2

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C14H17N3O2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 28936-94-9, Name is 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, molecular formula is C14H17N3O2. In a Patent, authors is ，once mentioned of 28936-94-9

The present invention relates to compounds having dual pharmacological activity towards both the sigma (sigma) receptor, and the mu-opiod receptor and more particularly to 1,9-diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H21289N – PubChem

Properties and Exciting Facts About 28936-94-9

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Related Products of 28936-94-9, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 28936-94-9

Related Products of 28936-94-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.28936-94-9, Name is 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, molecular formula is C14H17N3O2. In a Article£¬once mentioned of 28936-94-9

Synthesis and pharmacologic study of several spirohydantoins: relation to conformation

Using two routes starting from cyclanones, it has been possible to prepare two series of spirohydantoins substituted or not on the hydantoin nucleus nitrogen. These compounds exhibited low toxicity on pig lens aldose reductase (except for two compounds). A discussion is given on the steric and geometric requirements for effective enzyme inhibiting activity.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H21286N – PubChem

Brief introduction of 28936-94-9

The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.

28936-94-9, 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 20 L reactor 2.4 kg sodium hydroxide were dissolved in 10 L water. The solution was mixed with 614 g 1.38 (8-benzyl-1 ,3,8-triaza-spiro[4.5]decane-2,4-dione) and the resulting reaction suspension was heated to 80C. When 80C was reached, the reaction mixture was heated in steps of 10C. When the temperature reached 105C the mixture started to foam strongly. Stirring was continued at 108C overnight. The reaction mixture was cooled to 10C and 5 L concentrated hydrochloric acid were added dropwise to obtain a pH 7-8. During the addition the temperature was kept at 23C. The precipitate was filtered and dried in vacuo at 40C over 3 days, then at 80C overnight.Yield: 469.7 g I.39 (85% of theory), 28936-94-9

The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; FIEGEN, Dennis; FLECK, Martin; HOFFMANN, Matthias; KLICIC, Jasna; EAST, Stephen, Peter; NAPIER, Spencer, Charles, R.; SCOTT, John; WO2012/101013; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

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28936-94-9, The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28936-94-9,8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione,as a common compound, the synthetic route is as follows.

Exemplary Procedure for the Synthesis of Spiro-piperidine Hydantoin Scaffold for R1 Analogs. As depicted in Scheme 7 above, N-benzyl-4-piperidone (20 g, 106 mmol), NaCN (7.9 g, 160.4 mmol), and (NH4)2CO3 (52 g, 542 mmol) in EtOH (50 mL) and H2O (50 mL) was heated at 60 C. overnight. Upon cooling to ambient temperature, the white solid was filtered, washed with warm H2O, and dried in vacuo to provide 27.4 g. The solid (3.0 g, 11.6 mmol) was dissolved in DMF (30 mL), NaH (0.51 g of 60% dispersion in mineral oil, 12.8 mmol) was added, stirred at ambient temperature 2 hours, then 3-methoxybenzyl bromide (11.6 mmol) was added and the reaction was stirred overnight. Typical aqueous work-up provided 5.5 g ER-811159 as a solid which could be recrystallized from MeOH.

28936-94-9, The synthetic route of 28936-94-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gallagher, Brian M.; Carlson, Eric; Chen, Qian; Davis, Heather; Schiller, Shawn; Shaffer, Christina; Spyvee, Mark; Wong, Nancy; US2006/270696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

Brief introduction of 28936-94-9

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28936-94-9, 8-Benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Alternative Procedure for the Synthesis of Spiro-piperidine Hydantoin Scaffold for R1 Analogs. As depicted in Scheme 8 above, N-benzyl-4-piperidone (20 g, 106 mmol), NaCN (7.9 g, 160.4 mmol), and (NH4)2CO3 (52 g, 542 mmol) in EtOH (50 mL) and H2O (50 mL) was heated at 60 C. overnight. Upon cooling to ambient temperature, the white solid was filtered, washed with warm H2O, and dried in vacuo to provide 27.4 g. The solid (3.5 g, 13.3 mmol), 3-methoxybenzyl bromide (13.3 mmol), and DBU (20 mmol) were dissolved in NMP (30 mL), separated into 5 vials and each vial was microwave heated at 180 C. for 60 s. The batches were combined, subjected to typical aqueous work-up, then recrystallized from MeOH/MTBE/hexanes to provided 2.2 g ER-811159.

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