Category: 287953-54-2

Downstream synthetic route of 287953-54-2

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

287953-54-2, Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 190 mg (0.6 mmol) of benzyl 4-(chlorosulfonyl)-1-piperidinecarboxylate in 10 mL THF was treated with a 10-fold excess of 40% aq. dimethylamine and the mixture was stirred at room temperature for 2 hrs. The THF was removed under vacuum. The residue was diluted with water, extracted with CH2Cl2, and dried. Chromatography on alumina, eluting with CH2Cl2, gave 175 mg (89% yield) of benzyl 4-[(dimethylamino)sulfonyl]-1-piperidinecarboxylate as an oil: 1H NMR (CDCl3) delta 7.40-7.30 (m, 5H), 5.13 (s, 2H), 4.31 (m, 2H), 3.10 (tt, J=12.0, 3.7 Hz, 1H), 2.92 (s, 6H), 2.85-2.75 (m, 2H), 2.04 (br d, J=13.7 Hz, 2H), 1.76 (dq, J=12.6, 4.5 Hz, 2H).

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pathway Therapeutics Limited; US2010/249099; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 287953-54-2

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287953-54-2,Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(1) To a solution of Compound 1 (1574 mg) in dichloromethane (10 mL) was added an aqueous solution of dimethylamine (50% aqueous solution, 2 mL) under ice-cooling, and then the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added an aqueous solution of hydrochloric acid (0.5 mol/L) and chloroform, stirred, then the organic layer was separated, washed with saturated saline, dried, and then concentrated under reduced pressure to give Compound 2 (1.609 g) as a colorless viscous material. MS (APCI): m/z 327 [M+H] +

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 287953-54-2

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287953-54-2,Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(1) To a solution of Compound 1 (1574 mg) in dichloromethane (10 mL) was added an aqueous solution of dimethylamine (50% aqueous solution, 2 mL) under ice-cooling, and then the mixture was stirred at room temperature for 2 hours. To the reaction mixture were added an aqueous solution of hydrochloric acid (0.5 mol/L) and chloroform, stirred, then the organic layer was separated, washed with saturated saline, dried, and then concentrated under reduced pressure to give Compound 2 (1.609 g) as a colorless viscous material. MS (APCI): m/z 327 [M+H] +

287953-54-2, The synthetic route of 287953-54-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Mitsubishi Tanabe Pharma Corporation; YAMAMOTO, Yasuo; SATO, Atsushi; MOROKUMA, Kenji; SHITAMA, Hiroaki; ADACHI, Takashi; MIYASHIRO, Masahiko; (260 pag.)EP3150578; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Simple exploration of 287953-54-2

As the paragraph descriping shows that 287953-54-2 is playing an increasingly important role.

287953-54-2, Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 301; Preparation of N,N-dimethyl-1-(7-{5-[(phenylsulfonyl)amino]-3-pyridinyl}-2-quinoxalinyl)-4-piperidinesulfonamide; a) Phenylmethyl 4-[(dimethylamino)sulfonyl]-1-piperidinecarboxylate; A suspension of an amine such as dimethylamine (4.72 mmol) and sodium hydride (4.72 mmol) in N,N-dimethylformamide (10 ml) was stirred for five minutes at room temperature. Then phenylmethyl 4-(chlorosulfonyl)-1-piperidinecarboxylate (1.60 mmol) was added to the reaction mixture and stirred at 100 C. for 3 hours. The reaction mixture was poured into water (25 ml) and extracted with ethyl acetate (3¡Á25 ml). The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated to give the title compound (410 mg, 80% yield) as an off-white solid. MS (ES)+ m/e 327.1 [M+H]+.; Intermediate 17; Preparation of N,N-dimethyl-4-piperidinesulfonamide; a) phenylmethyl 4-[(dimethylamino)sulfonyl]-1-piperidinecarboxylate; A suspension of an amine such as dimethylamine (4.72 mmol) and sodium hydride (4.72 mmol) in N,N-dimethylformamide (10 ml) was stirred for five minutes at room temperature. Then phenylmethyl 4-(chlorosulfonyl)-1-piperidinecarboxylate (1.60 mmol) was added to the reaction mixture and stirred at 100 C. for 3 hours. The reaction mixture was poured into water (25 ml) and extracted with ethyl acetate (3¡Á25 ml). The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated to give the title compound (410 mg, 80% yield) as an off-white solid. MS (ES)+ m/e 327.1 [M+H]+.

As the paragraph descriping shows that 287953-54-2 is playing an increasingly important role.

Reference£º
Patent; CHAUDHARI, Amita; DHANAK, Dashyant; DONATELLI, Carla Ann; FAITG, Thomas H.; FENG, Yanhong; KNIGHT, Steven David; PARRISH, Cynthia A.; RALPH, Jeffrey M.; US2008/293706; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem