Category: 276872-89-0

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Application In Synthesis of N-Boc-3-Methylenepiperidine, Which mentioned a new discovery about 276872-89-0

The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn’s disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Application In Synthesis of N-Boc-3-Methylenepiperidine, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 276872-89-0

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12964N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C11H19NO2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 276872-89-0

The present invention relates to thienopyridazine compounds of formula (I), their pharmaceutically acceptable salts or hydrates, wherein R1 and R2 are independently H or C1-4 alkyl, R3 is a saturated or unsaturated 5- or 6- membered ring containing N, S or O, or its optical isomers, R4 is a halophenyl monosubstituted or disubstituted at any position. The present invention provides the preparation methods of these compounds, pharmaceutical compositions containing these compounds and the uses of these compounds, particularly in treating cancer.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C11H19NO2, you can also check out more blogs about276872-89-0

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12961N – PubChem

Application of 276872-89-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.276872-89-0, Name is N-Boc-3-Methylenepiperidine, molecular formula is C11H19NO2. In a Article，once mentioned of 276872-89-0

The synthesis of monocyclic, spirocyclic and fused bicyclic secondary amines bearing a gem-difluorocyclopropane moiety via difluorocyclopropanation of unsaturated N-Boc derivatives using the trifluoromethyl(trimethyl)silane/sodium iodide [CF3SiMe3-NaI] system is described. The relative order of the substrate reactivity is established. It is shown that for the reactive alkenes the standard reaction conditions can be used, whereas for the substrates with low reactivity, slow addition of the Ruppert?Prakash reagent is necessary. (Figure presented.).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 276872-89-0

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12960N – PubChem

276872-89-0, N-Boc-3-Methylenepiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of N-Boc-3-methylenepyrazdine (0.4 g) and 9-BBN (12 ml) was cooled to 0 C. for 30 min, and then warmed to room temperature for 2 h. Dioxane (20 ml), PdCl2 (0.05 g), K3PO4 (0.32 g) and 4-chloro-2-(4-chlorophenyl)-thieno[2,3-d]pyridzaine-7-carboxylic acid ethyl ester were heated at 90 C. over night. The reaction mixture was cooled, diluted with ethyl acetate and washed with water. The organic layer was washed with brine, dried over anhydrous Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, PE_EA=5:10) to obtain 4-(1-Boc-3-piperidinemethy)-2-(4-chlorophenyl)-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester as a solid (0.3 g). 1H-NMR (400 MHz, DMSO), delta 8.90 (s, 1H), 8.03 (m, 2H), 7.63 (m, 2H), 4.54 (m, 2H), 3.73 (s, 2H), 3.32 (m, 2H), 3.28 (m, 1H), 2.82 (m, 2H), 2.09 (s, 1H), 1.78 (s, 1H), 1.64 (s, 1H), 1.44 (m, 3H), 1.39 (s, 1H), 1.32 (s, 9H). MS (EI): 515 (M+), 486, 458, 442, 414, 334, 332, 306, 304, 149, 57.

276872-89-0, 276872-89-0 N-Boc-3-Methylenepiperidine 11252594, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Wu, Zhanggui; US2009/275585; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem