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2-(-BICYCLO)ALKYLAMINO-DERIVATIVES AS MEDIATORS OF CHRONIC PAIN AND INFLAMMATION

Compounds disclosed herein are bradykinin B1 antagonist compounds useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

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Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: A new class of telomerase inhibitors

In developing G-quadruplex interactive telomerase inhibitors two main features have to be taken into account: the hydrophobic interactions with the G-quartet plane and the electrostatic interactions with the negatively charged phosphates of the four grooves. In this paper, we report the synthesis of four hydrosoluble coronene derivatives, which are characterized by a large hydrophobic aromatic core and four orthogonal hydrophilic side chains. We have studied their ability to induce both inter- and intramolecular G-quadruplex structures and found a significant selectivity of all the coronene derivatives for the intramolecular G-quadruplex. The efficiency in inhibiting human telomerase has been evaluated in a cell-free system and the experimental results correlate with the relative affinities of these compounds for the G-quadruplex monomeric structure, as derived by molecular modelling simulations. Thus, the coronene derivatives can be considered as a new class of telomerase inhibitors, although further investigations are surely necessary to fully exploit their features.

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Synthetic Route of 27578-60-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 27578-60-5, Name is N-(2-Aminoethyl)piperidine, molecular formula is C7H16N2. In a Article£¬once mentioned of 27578-60-5

Synthesis and pharmacological properties of 1-(4-substituted)butyl derivatives of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4- tetrahydropyrido[2,3-d]pyrimidine-5-carboxylic acid

The synthesis of 1-(4-substituted)butyl derivatives of amides of 7- methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5- carboxylic acid and the results of the preliminary pharmacological screening are described in this paper. Some of them showed a weak analgesic action and caused suppression of the spontaneous locomotor activity of mice. (C) 2000 Elsevier Science S.A.

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Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C7H16N2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 27578-60-5

[6-(substituted-methyl)-3-cyclohexenyl] formamide derivative, hair growth promoter and external composition for skin

A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is?(CH2)n-NR2R3; Z is ?O?, ?OCO?, ?OCONR6? or ?NR6?; R2 and R3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; ?NR5?(CH2)n-NR2R3 or ?NR6?(CH2)n-NR2R3 may be Group W, and ?OCONR6?(CH2)n-NR2R3 may be ?OCO?W, wherein W is a formula of: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, lower alkyl, phenyl or benzyl group; R4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R5 and R6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

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Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 27578-60-5. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 27578-60-5

[6-(substituted-methyl)-3-cyclohexenyl] formamide derivative, hair growth promoter and external composition for skin

A [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30 expressed by R1 and the other is?(CH2)n-NR2R3; Z is ?O?, ?OCO?, ?OCONR6? or ?NR6?; R2 and R3 individually represent a hydrogen, lower alkyl, phenyl or benzyl group, or together represent a heterocycle having 3-7 members; ?NR5?(CH2)n-NR2R3 or ?NR6?(CH2)n-NR2R3 may be Group W, and ?OCONR6?(CH2)n-NR2R3 may be ?OCO?W, wherein W is a formula of: wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R2 is a hydrogen, lower alkyl, phenyl or benzyl group; R4 is a halogen, lower alkyl, lower acyl, nitro, cyano, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkylamino, lower acylamino, lower alkoxy or lower acyloxy group; each of R5 and R6 is a hydrogen, lower alkyl, lower acyl, lower alkylcarbamoyl group, or a part of said Group W; m is an integer of 0-2; and n is an integer of 0-5. The [6-(substituted-methyl)-3-cyclohexenyl]formamide derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

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Application of 27578-60-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 27578-60-5, Name is N-(2-Aminoethyl)piperidine,introducing its new discovery.

Synthesis, crystal structures, and biological activity of schiff base zinc(II) complexes derived from (2-piperidin-1-ylethyl)-(1-pyridin-2- ylethylidene)amine

Two new similar zinc(II) complexes, [ZnI2L] (1) and [Zn(NCS)2L] (2), derived from the Schiff base (2-piperidin-1-ylethyl) -(1-pyridin-2-ylethylidene)amine(L), were prepared and structurally characterized by X-ray diffraction. The Zn atom in each complex is five-coordinated by the three N atoms of the Schiff base ligand, and by two I or N atoms of the terminal iodide or thiocyanate groups, forming distorted square-pyramidal coordination. The urease inhibitory activities of the complexes and the ligand were evaluated. Copyright Taylor & Francis Group, LLC.

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Application of 27578-60-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.27578-60-5, Name is N-(2-Aminoethyl)piperidine, molecular formula is C7H16N2. In a Article£¬once mentioned of 27578-60-5

Imine Analogues of Tricyclic Antidepressants

Analogues of tricyclic antidepressants were synthesized in which the alpha-carbon of the side chain was replaced by nitrogen.The antidepressant activity of these imines, as measured by the reversal of the effects of tetrabenazine in mice, showed a structure-activity relationship similar to that of the carbon analogues.The most active imine (19) was six times as potent as amitriptyline.Some of the compounds differed from amitriptyline in that they produced stimulation in mice.

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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Recommanded Product: N-(2-Aminoethyl)piperidine, Which mentioned a new discovery about 27578-60-5

NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED-3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides, inter alia, compounds of formula IA,IIA and III as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 27578-60-5, molcular formula is C7H16N2, introducing its new discovery. SDS of cas: 27578-60-5

NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS

The present invention relates to nicotinamide derivatives of formula (I), to compositions containing same, and to the therapeutic use thereof, in particular as anticancer drugs. The invention also relates to the method for preparing said compounds, as well as to some of the intermediate products.

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Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors

A series of 3-anilino-quinoxalinones has been identified as a new class of glycogen phosphorylase inhibitors. The lead compound 1 was identified through high throughput screening as well as through pharmacophore-based electronic screening. Modifications were made to the scaffold of 1 to produce novel analogues, some of which are 25 times more potent than the lead compound.

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