Category: 27469-60-9

Preparation and spectral properties of novel N,S-substituted trichloronitrodienes was written by Gokmen, Zeliha;Hanay, Nur;Deniz, Nahide Gulsah. And the article was included in Journal of the Chemical Society of Pakistan in 2016.Category: piperazines This article mentions the following:

A series of piperazinyl(sulfanyl)trichloronitrodienes I [R¹ = Et, cyclopentyl, 4-ClC₆H₄, 4-t-BuC₆H₄CH₂; R² = 2-tetrahydrofurylmethyl, 2-furylcarbonyl, bis(4-fluorophenyl)methyl, etc.] was synthesized via regioselective substitution of sulfide-containing nitrodienes II with piperazine derivatives The nitrodienes II were obtained by the reaction of polyhalo-3-nitrobutadiene with thiols. The structures of N,S-substituted trichloronitrodienes I were characterized by microanal., FT-IR, ¹H NMR, ¹³C NMR and mass spectrometry. The high temperature NMR technique was used for determination of methylene protons of piperazine ring in the new compound I (R¹ = 4-t-BuC₆H₄CH₂; R² = 2-furylcarbonyl). In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Category: piperazines).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Chemiluminescence detection of piperazine designer drugs and related compounds using tris(2,2′-bipyridine)ruthenium(III) was written by Waite, Rebecca J.;Barbante, Gregory J.;Barnett, Neil W.;Zammit, Elizabeth M.;Francis, Paul S.. And the article was included in Talanta in 2013.COA of Formula: C17H18F2N2 This article mentions the following:

The authors present an exploration of the chemiluminescence from reactions of benzylpiperazines and phenylpiperazines with tris(2,2′-bipyridine)ruthenium(III). The selectivity of the reagent towards these compounds was found to be highly dependent upon the pH of the solution, and the relative emission intensity was strongly influenced by electron donating or withdrawing substituents on the Ph or benzyl ring. In spite of previous investigations showing poor responses for aromatic-substituted amines (compared to their aliphatic amine counterparts), intense emissions were observed with phenylpiperazines under acidic conditions, particularly those with halogen or trifluoromethyl substituents on the aromatic ring. Buffered alk. conditions provided much broader selectivity for the detection of both phenylpiperazine and benzylpiperazine compounds, which the authors have applied to a rapid HPLC procedure for the determination of piperazines of forensic interest in ‘party pill’ samples. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9COA of Formula: C17H18F2N2).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.COA of Formula: C17H18F2N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4 was written by Andonova, Lily;Zheleva-Dimitrova, Dimitrina;Georgieva, Maya;Zlatkov, Alexander. And the article was included in Biotechnology & Biotechnological Equipment in 2014.Recommanded Product: 27469-60-9 This article mentions the following:

Six new aryl/aralkyl substituted piperazine derivatives, containing methylxanthine moiety I (R = Bn, 4-FC₆H₄, 4-HOC₆H₄, etc.) were synthesized. All compounds were in vitro screened for their activity as antioxidants using DPPH (2,2′-Diphenyl-1-picrylhydrazyl), ABTS (2,2′-azinobis-(3-ethylbenzothiazine-6-sulfonic acid)) and FRAP (ferric reducing/antioxidant power) methods. The antioxidant activity of the studied compounds against lipid peroxidation was also measured. The highest antioxidant activity was demonstrated by compound I (R = 4-HOC₆H₄). It is obvious that the presence of a hydroxyl group in the structure is essential for the antioxidant properties and should be taken into consideration in further design of structures with potential antioxidant properties. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Recommanded Product: 27469-60-9).

4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Recommanded Product: 27469-60-9

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics