Category: 256411-39-9

Some tips on 256411-39-9

256411-39-9, The synthetic route of 256411-39-9 has been constantly updated, and we look forward to future research findings.

256411-39-9, 1-Boc-4-(Cyanomethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a round-bottomed flask, 13.4?mL of HCl in dioxane (4?M) was added 32 (400?mg, 1.78?mmol). After 1?h, Boc deprotection was completed and the solvent was removed under vacuum to afford 33 in quantitative yield. The crude material was used without further purification for the next step.

256411-39-9, The synthetic route of 256411-39-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Forcellini, Elsa; Boutin, Sophie; Lefebvre, Carole-Anne; Shayhidin, Elnur Elyar; Boulanger, Marie-Chloe; Rheaume, Gabrielle; Barbeau, Xavier; Laguee, Patrick; Mathieu, Patrick; Paquin, Jean-Francois; European Journal of Medicinal Chemistry; vol. 147; (2018); p. 130 – 149;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Simple exploration of 256411-39-9

The synthetic route of 256411-39-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.256411-39-9,1-Boc-4-(Cyanomethyl)piperidine,as a common compound, the synthetic route is as follows.

256411-39-9, t-BuOK (3 g, 26.7 mmol) was added portionwisely to a solution of tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate (1 g, 4.46 mmol) in DMF (40 mL) at 510 C. After addition, the mixture was stirred for 30 min. A solution of ethyl formate (2 g, 26.7 mmol) in DMF (10 mL) was added dropwise. Then the mixture was allowed to warm to RT and stirred at 35 C. for 12 h (overnight). 10 mL of water was added to quench the reaction. The solvent was removed under reduced pressure. 100 mL of water was added and extracted with EA (20 mL¡Á2). The combined organic phases were dried over Na2SO4, filtered and concentrated to give 1 g (90%) of desired product as a yellow solid. 1H NMR (400 MHz, CDCl3-d1) delta 8.88 (br s, 1H), 4.16-4.08 (m, 2H), 2.84-2.64 (m, 2H), 1.81-1.62 (m, 2H), 1.57-1.38 (m, 2H), 1.46 (s, 9H), 1.31-1.23 (m, 1H). MS (ESI) m/e [M+23]+ 275.1

The synthetic route of 256411-39-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wang, Zhiwei; Guo, Yunhang; US2015/5277; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

New learning discoveries about 256411-39-9

256411-39-9 1-Boc-4-(Cyanomethyl)piperidine 22248390, apiperidines compound, is more and more widely used in various fields.

256411-39-9, 1-Boc-4-(Cyanomethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00860] 2.5 M n-BuLi in THF (0.28 mL, 0.7 mmol) was added to a solution of diisopropylamine (54 mg, 0.536 mmol) in THF (2 mL) at -78 C. The solution was stirred for 30 min and then a solution of tert-butyl 4-(cyanomethyl)piperidine-l-carboxylate (100 mg, 0.446 mmol) was added dropwise at -78 C . The resulting solution was stirred for 1 h and iodoethane (83.6 mg, 0.536 mmol) was added. The reaction mixture was stirred overnight. The reaction was quenched with sat. NH4C1 (5 mL), extracted with EtOAc (30 mLX2), the combined organics were dried over Na2S04, concentrated to yield the product (110 mg, 98% yield) which was used in the next step without purification. [00861] LC-MS: m/z = 197 (M-55)+, RT = 1.70 min., 256411-39-9

256411-39-9 1-Boc-4-(Cyanomethyl)piperidine 22248390, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; QUARTET MEDICINE, INC.; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); TEBBE, Mark, Joseph; ATTON, Holly, Victoria; AVERY, Craig; BROMIDGE, Steven, Mark; KERRY, Mark; KOTEY, Adrian, Kotei; MONCK, Nathaniel, J.; MENICONI, Mirco; RIDGILL, Mark, Peter; TYE, Heather; SAIAH, Eddine; JOHNSSON, Kai, Peter; GORSKA, Katarzyna, Irena; PENG, Hairuo; MCCALL, John, Michael; (356 pag.)WO2017/59191; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Simple exploration of 256411-39-9

The synthetic route of 256411-39-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.256411-39-9,1-Boc-4-(Cyanomethyl)piperidine,as a common compound, the synthetic route is as follows.

Step A: 4-(N-HYDROXYCARBAMIMIDOYLMETHYL) PIPERIDINE-1-CARBOXYLIC acid tert-butyl ester. To a solution OF 4- (CYANOMETHYL) PIPERIDINE-1-CARBOXYLIC acid tert-butyl ester (2.2 g, 10 MMOL, prepared as described in Example 12) in absolute ethanol (20 mL) was added hydroxylamine hydrochloride (2.1 g, 30 MMOL), water (4 mL) and potassium carbonate (2.2 g, 16 MMOL). The reaction mixture was stirred 30 min. at ambient temperature and then heated overnight at reflux for 6 h. Water (10 mL) was added and the mixture was allowed to cool on an ice-bath. The solid inorganic material was removed by filtration and the solvent was evaporated. The residue was treated with DICHLOROMETHANE, dried and evaporated. The oily residue was sub- mitted to column chromatography (100 g, kiselgel 60) with ethyl acetate as eluent. The frac- tions eluting at Rf = 0.32 were collected to give 0.67 g OF 4- (N- HYDROXYCARBAMIMIDOYLMETHYL) PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER.’H NMR (400 MHz, CDCI3) 8 1.07-1. 20 (m, 2H), 1.45 (s, 9H), 1.67-1. 77 (m, 3H), 2.06 (d, 2H), 2.62-2. 77 (m, 2H), 4.1 (brs, 2H), 4.54 (s, 2H), 7.7 (brs, 1H). HPLC: Rt = 6.43 min.

The synthetic route of 256411-39-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVO NORDISK A/S; WO2004/54973; (2004); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem