Category: 25519-78-2

Reference of 25519-78-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 25519-78-2, Name is (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride, molecular formula is C12H15ClFNO. In a Patent£¬once mentioned of 25519-78-2

Piperidinylalkyl quinazoline compounds, composition and method of use

Novel quinazoline derivatives, comprising in the heterocyclic part of their quinazoline nucleus at least one carbonyl or thiocarbonyl group and a particularly substituted piperidinyl-alkyl side chain, said compounds being potent serotonin-antagonists.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Reference of 25519-78-2, you can also check out more blogs about25519-78-2

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Piperidine – Wikipedia,
Piperidine | C5H20277N – PubChem

 

25519-78-2, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 25519-78-2, Name is (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride,introducing its new discovery.

4-aroylpiperidines and 4-(alpha-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: Synthesis, preliminary pharmacological evaluation and computational studies

Background: Sigma (sigma) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and their potential as alternative targets for antipsychotic agents. Sigma receptors display diverse biological activities and represent potential fruitful targets for therapeutic development in combating many human diseases. Therefore, they present an interesting avenue for further exploration. It was our goal to evaluate the potential of ring opened spipethiane (1) analogues as functional ligands (agonists) for sigma receptors by chemical modification. Results: Chemical modification of the core structure of the lead compound, (1), by replacement of the sulphur atom with a carbonyl group, hydroxyl group and 3-bromobenzylamine with the simultaneous presence of 4-fluorobenzoyl replacing the spirofusion afforded novel potent sigma-1 receptor ligands 7a-f, 8a-f and 9d-e. The sigma-1 receptor affinities of 7e, 8a and 8f were slightly lower than that of 1 and their selectivities for this receptor two to threefold greater than that of 1. Conclusions: It was found that these compounds have higher selectivities for sigma-1 receptors compared to 1. Quantitatitive structure-activity relationship studies revealed that sigma-1 binding is driven by hydrophobic interactions. Graphical abstract Identified pharmacophore features for sigma binding.

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Piperidine – Wikipedia,
Piperidine | C5H20298N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25519-78-2,(4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride,as a common compound, the synthetic route is as follows.

25519-78-2, 5-Methyl-3-phenylisooxazole-4-carboxylic acid (40 mg, 0.197 mmol), 4-(4-Fluorobenzoyl)piperidine hydrochloride (31.4 mg, 0.151 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (37.7 mg, 0.197 mmol) and triethylamine (59.8 mg, 0.591 mmol) were mixed in dichloromethane (2 ml) and stirred at room temperature over night. Solvent was evaporated in vacuo, and the residue was taken up in methanol (1 mL), filtered and purified by preparative chromatography. The fractions were partitioned between NaHCO3 (sat) and ethylacetate. The organic layer was washed with water and concentrated in vacuo to afford the title compound. HRMS (ESI, pos. ion) m/z calcd for C23H21FN2O3: 392.1536, found 392.1542.

25519-78-2 (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride 3084438, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Amgen Inc.; Biovitrum AB; US2008/21022; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem