Category: 252882-61-4

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Safety of Spiro[indoline-3,4′-piperidin]-2-one, Which mentioned a new discovery about 252882-61-4

The present invention is directed to conformationally constrained compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

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Piperidine – Wikipedia,
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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， HPLC of Formula: C12H14N2O, Which mentioned a new discovery about 252882-61-4

A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11beta-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11beta-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).

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Piperidine | C5H15086N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， category: piperidines, Which mentioned a new discovery about 252882-61-4

The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, category: piperidines, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 252882-61-4

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Piperidine – Wikipedia,
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Electric Literature of 252882-61-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 252882-61-4, Name is Spiro[indoline-3,4′-piperidin]-2-one, molecular formula is C12H14N2O. In a Article，once mentioned of 252882-61-4

We report the synthesis of rigid spirocyclic systems as conformationally constrained variants of the Ala-Phe-NH2 dipeptide amide C-terminus of the calcitonin gene-related peptide (CGRP). CGRP receptor antagonists containing these moieties displayed potent affinity, functional antagonism and excellent oxidative stability. Structure-activity relationship studies demonstrated the relative importance of hydrogen bond donor/acceptor functionalities and the preferred orientation of an aromatic ring. Antagonists showed potent and full reversal of CGRP-induced dilation of ex vivo human intracranial arteries.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Electric Literature of 252882-61-4, you can also check out more blogs about252882-61-4

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Piperidine – Wikipedia,
Piperidine | C5H15077N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252882-61-4,Spiro[indoline-3,4′-piperidin]-2-one,as a common compound, the synthetic route is as follows.

Process 2Production of 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-oneTo a methylene chloride solution (5 mL) of spiro (indole-3,4′-piperidine)-2(1H)-one (50.0 mg, 0.247 mmol), 2-trifluoromethoxyphenoxyacetic acid (58.4 mg, 0.247 mmol), PyBOP (142 mg, 0.272 mmol), and diisopropylethylamine (63.9 mg, 0.494 mmol) were added sequentially at room temperature. The mixture was stirred at the same temperature for 5 hours. The reaction solution was added with water and then extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, followed by a vacuum concentration. The resultant residue was purified by preparative thin-layer chromatography (hexane:ethyl acetate=1:2) and 1′-{2-(2-trifluoromethoxyphenoxy)acetyl}spiro(indole-3,4′-piperidine)-2(1H)-one (33.0 mg, 31.8%) was obtained as a colorless amorphous solid.1H-NMR (400 MHz, CDCl3) delta; 1.83-1.91 (m, 4H), 3.80-3.86 (m, 1H), 3.90-3.97 (m, 1H), 4.03 (quint, J=6.8 Hz, 1H), 4.24-4.30 (m, 1H), 4.79 (d, J=12.9 Hz, 1H), 4.87 (d, J=12.9 Hz, 1H), 6.91 (t, J=7.8 Hz, 1H), 7.00-7.30 (m, 7H), 8.58 (s, 1H).IR(ATR); 3217,1711,1632,1471,1223,755 cm-1.EI-MS m/z; 420(M+)., 252882-61-4

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Reference£º
Patent; KOWA CO., LTD.; US2008/306102; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem