Category: 24666-56-6

Downstream synthetic route of 24666-56-6

24666-56-6, As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.

24666-56-6, 3-Aminopiperidine-2,6-dione hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-aminopiperidine-2,6- dione hydrochloride (500 mg, 3.04 mmol) and triethylamine (931 muL, 6.68 mmol) in DCM (3 mL) was heated in a sealed 20 mL microwave vial at 50 ¡ãC for 30 min. The mixture was cooled to 0 ¡ãC and di-tert-butyl dicarbonate (663 mg, 3.04 mmol) in DCM (1 mL) was added via syringe, and stirring at 0 ¡ãC was continued for a further 30 min. The mixture was concentrated under vacuum and ethyl acetate (200 mL) added. The resulting mixture was washed with NaHCO3 (100 mL, sat. aq.), brine (50 mL), dried (Na2SO4) and concentrated under vacuum. Trituration of the residue with ethyl acetate/hexanes gave pure product (601 mg, 87percent) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 10.73 (s, 1H), 7.12 (d, J = 8.7 Hz, 1H), 4.20 (ddd, J = 11.5, 8.7, 6.2 Hz, 1H), 2.69 (ddd, J = 17.2, 12.3, 6.5 Hz, 1H), 2.49?2.40 (m, 1H, overlapped with the residual DMSO signal), 1.99?1.81 (m, 2H), 1.38 (s, 9H).

24666-56-6, As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.

Reference£º
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; BURNETTE, Pearlie; LAWRENCE, Harshani; LAWRENCE, Nicholas J.; (285 pag.)WO2017/161119; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Some tips on 24666-56-6

24666-56-6 3-Aminopiperidine-2,6-dione hydrochloride 134548, apiperidines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.

Methyl-4-bromo-2-(bromomethyl) benzoate (100 g, 324.70 mmol), 3-Aminopiperidine-2,6-dione.hydrochloride (53.2 g, 324.70 mmol), triethylamine (113.29 mL, 811.75 mmol), and dry dimethylformamide (400 mL) were combined and stirred at room temperature under inert atmosphere for 18 hours. The reaction was cooled to 5C and diluted with water (400 mL), acetic acid (115 mL), diethylether (300 mL) with continued stirring at room temperature for 2 hours. The resultant solid was filtered, washed with ether (100 mL) and further dried under high vacuum to give 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione (46 g, 142.35 mmol, 43.8 % yield) as a light blue solid. MS(ESI) m/z 325.0 [M+1].

24666-56-6 3-Aminopiperidine-2,6-dione hydrochloride 134548, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; CELGENE CORPORATION; ALEXANDER, Matthew, D.; CORREA, Matthew, D.; HANSEN, Joshua; RAHEJA, Raj, Kumar; SAPIENZA, John; (128 pag.)WO2017/120422; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem