Category: 240401-22-3

240401-22-3, Piperidine-4-carbonitrile hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a dry round bottom flask was placed 4-cyanopiperidinium chloride (13, 5g, 45.4 mmol) dichloromethane (150ml) and triethylamine (18.98ml, 136 mmol). To the reaction was added dropwise ethanesulfonyl chloride (4.56 ml, 45.4 mmol) and the solution stirred 1 hour and quenched with water (100 ml). The mixture was extracted with dichloromethane (3x 50 ml) and the combined organic fractions dried (MgSO4), filtered, and the solvent evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with EtOAc/Hexanes to give 1- (ethylsulfonyl)pirhoeridine-4-carbonitrile (14) as a white solid. MS 203 (M+l), 240401-22-3

240401-22-3 Piperidine-4-carbonitrile hydrochloride 22744637, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; MERCK SHARP & DOHME LIMITED; WO2007/53400; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem