Category: 2403-88-5

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Quality Control of 2403-88-5.

Asif, Muhammad Bilal;Ji, Bingxuan;Maqbool, Tahir;Zhang, Zhenghua research published 《 Algogenic organic matter fouling alleviation in membrane distillation by peroxymonosulfate (PMS): Role of PMS concentration and activation temperature》, the research content is summarized as follows. Membrane distillation (MD) has attracted significant attention in recent years; however, MD membrane fouling is still a big issue. For the first time, this study explored the performance of a standalone direct contact membrane distillation (DCMD) and an integrated peroxymonosulfate (PMS)/DCMD for the treatment of surface water mainly containing algogenic organic matter (AOM) to elucidate pollutant removal as well as fouling propensity and mitigation. The results indicated that the overall conductivity and dissolved organic carbon (DOC) removals by the standalone DCMD and PMS/DCMD were comparable (98-99.8%). However, permeate flux of the standalone DCMD reduced by 62% due to severe membrane fouling. After pre-treatment at 60°C, flux reduction of 27-40% and no flux decline were observed at PMS concentrations of 1-5 mM and 10-15 mM, resp. The optimum PMS concentration of 10 mM was also demonstrated to be effective for membrane fouling mitigation at 40 and 50°C. Characterization of AOM indicated the presence of protein-like and high MW (≥10 kDa) compounds, which were readily degraded by the reactive species (OH. and ¹O₂) generated by heat-activated PMS. Characterization of fouled MD membrane confirmed that fouling was mainly caused by protein-like compounds, consequently affecting permeate flux and membrane properties.

Quality Control of 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Formula: C9H19NO.

Barrios, Benjamin;Mohrhardt, Benjamin;Doskey, Paul V.;Minakata, Daisuke research published 《 Mechanistic Insight into the Reactivities of Aqueous-Phase Singlet Oxygen with Organic Compounds》, the research content is summarized as follows. Singlet oxygen (¹O₂) is a selective reactive oxygen species that plays a key role for the fate of various organic compounds in the aquatic environment under sunlight irradiation, engineered water oxidation systems, atm. water droplets, and biomedical systems. While the initial rate-determining charge-transfer reaction mechanisms and kinetics of ¹O₂ have been studied extensively, no comprehensive studies have been performed to elucidate the reaction mechanisms with organic compounds that have various functional groups. In this study, we use d. functional theory calculations to determine elementary reaction mechanisms with a wide variety of organic compounds The theor. calculated aqueous-phase free energies of activation of single electron transfer and ¹O₂ addition reactions are compared to the exptl. determined rate constants in the literature to determine linear free-energy relationships. The theor. calculated free energies of activation for the groups of phenolates and phenols show excellent correlations with the Hammett constants that accept electron densities by through-resonance. The dominant elementary reaction mechanism is discussed for each group of compounds As a practical implication, we demonstrate the fate of environmentally relevant organic compounds induced by photochem. produced intermediate species at different pH and evaluate the impact of predicting rate constants to the half-life.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Formula: C9H19NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Electric Literature of 2403-88-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, belongs to piperidines compound. In a article, author is Kangani, Mehrnoush, introduce new discover of the category.

Lactic Acid: An Efficient and Green Catalyst for the One-Pot Five-Components Synthesis of Highly Substituted Piperidines

Polyfunctionalized heterocyclic compounds have an important role in the drug discovery process and analysis of drugs in late development. Piperidines and their analogues have received attention owing to their biological activities, because of the importance of these heterocycle compounds, there is still a need to improve the ways for green synthesis of these compounds. In this study, lactic acid was applied as a green and efficient catalyst for the one-pot five-component synthesis of highly substituted piperidines from the reaction between aromatic aldehydes, aromatic amines, and b-ketoester at ambient temperature. This methodology has a number of advantages such as: use of easy access and green catalyst, short reaction times, high yields, and easy work-up (just simple filtration).

Electric Literature of 2403-88-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2403-88-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of 2,2,6,6-Tetramethyl-4-piperidinol, 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, molecular formula is C9H19NO, belongs to piperidines compound. In a document, author is Cui, Peng, introduce the new discover.

Proteomic and metabolic profile analysis of low-temperature storage responses inIpomoea batataLam. tuberous roots

Background Sweetpotato (Ipomoea batatasL.) is one of the seven major food crops grown worldwide. Cold stress often can cause protein expression pattern and substance contents variations for tuberous roots of sweetpotato during low-temperature storage. Recently, we developed proteometabolic profiles of the fresh sweetpotatoes (cv. Xinxiang) in an attempt to discern the cold stress-responsive mechanism of tuberous root crops during post-harvest storage. Results For roots stored under 4 degrees C condition, the CI index, REC and MDA content in roots were significantly higher than them at control temperature (13 degrees C). The activities of SOD, CAT, APX, O(2)(.-)producing rate, proline and especially soluble sugar contents were also significantly increased. Most of the differentially expressed proteins (DEPs) were implicated in pathways related to metabolic pathway, especially phenylpropanoids and followed by starch and sucrose metabolism. L-ascorbate peroxidase 3 and catalase were down-regulated during low temperature storage. alpha-amylase, sucrose synthase and fructokinase were significantly up-regulated in starch and sucrose metabolism, while beta-glucosidase, glucose-1-phosphate adenylyl-transferase and starch synthase were opposite. Furthermore, metabolome profiling revealed that glucosinolate biosynthesis, tropane, piperidine and pyridine alkaloid biosynthesis as well as protein digestion and absorption played a leading role in metabolic pathways of roots. Leucine, tryptophan, tyrosine, isoleucine and valine were all significantly up-regulated in glucosinolate biosynthesis. Conclusions Our proteomic and metabolic profile analysis of sweetpotatoes stored at low temperature reveal that the antioxidant enzymes activities, proline and especially soluble sugar content were significantly increased. Most of the DEPs were implicated in phenylpropanoids and followed by starch and sucrose metabolism. The discrepancy between proteomic (L-ascorbate peroxidase 3 and catalase) and biochemical (CAT/APX activity) data may be explained by higher H(2)O(2)levels and increased ascorbate redox states, which enhanced the CAT/APX activity indirectly. Glucosinolate biosynthesis played a leading role in metabolic pathways. Leucine, tryptophan, tyrosine, isoleucine and valine were all significantly up-regulated in glucosinolate biosynthesis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2403-88-5. Safety of 2,2,6,6-Tetramethyl-4-piperidinol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 2403-88-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, belongs to piperidines compound. In a article, author is Abd Alhameed, Rakia, introduce new discover of the category.

Novel 4,6-Disubstituted s-Triazin-2-yl Amino Acid Derivatives as Promising Antifungal Agents

A novel series of 4,6-disubstituted s-triazin-2-yl amino acid derivatives was prepared and characterized. Most of them showed antifungal activity against Candida albicans compared to clotrimazole (standard drug). Compounds bearing aniline derivatives, piperidine and glycine on the triazine core showed the highest inhibition zones at concentrations of 50, 100, 200, and 300 mu g per disc. In addition, docking studies revealed that all the compounds accommodated well in the active site residues of N-myristoltransferase (NMT) and exhibited complementarity, which explains the observed antifungal activity. Interestingly, none of these compounds showed antibacterial activity.

Electric Literature of 2403-88-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2403-88-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Stumpf, Andreas, once mentioned the application of 2403-88-5, Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol, Name is 2,2,6,6-Tetramethyl-4-piperidinol, molecular formula is C9H19NO, molecular weight is 157.25, MDL number is MFCD00005983, category is piperidines. Now introduce a scientific discovery about this category.

Practical Early Development Synthesis of Nav1.7 Inhibitor GDC-0310

The concise early development route to the Nav1.7 inhibitor GDC-0310 is described. The active pharmaceutical ingredient (API) contains one stereocenter, which was obtained with high enantiomeric excess (>99:1) by using an S(N)2 displacement approach to connect two intermediates: a chiral benzyl alcohol and a piperidine. The synthesis of the piperidine building block proceeded via a regioselective SNAr reaction on 1-chloro-2,4-difluorobenzene byN-Boc-4-piperidinemethanol, followed by installation of the methyl ester group by electrophilic aromatic bromination and a palladium-catalyzed alkoxycarbonylation. A subsequent Suzuki-Miyaura cross-coupling reaction was then telescoped directly into cleavage of the Boc group to provide the advanced piperidine intermediate. The key feature of the synthesis is the highly selective S(N)2 displacement of the chiral mesylate of (R)-1-(3,5-dichlorophenyl)ethan-1-ol with the piperidine intermediate, followed by a chiral purity upgrade via the corresponding (1S)-(+)-camphorsulfonic acid salt. After standard hydrolysis of the methyl ester and CDI mediated amidation to couple the resulting acid with methanesulfonamide, enantiomerically pure GDC-0310 was obtained in high overall yield (37%) on a 6.5 kilogram scale.

If you are interested in 2403-88-5, you can contact me at any time and look forward to more communication. Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of C9H19NO, 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, belongs to piperidines compound. In a document, author is Nonn, Melinda, introduce the new discover.

Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing beta-Amino Acid Derivatives

Structural diversity-oriented synthesis of some azaheterocyclic beta-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic beta-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted beta-amino acid derivatives with a piperidine or azepane core.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 2403-88-5. Computed Properties of C9H19NO.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 2403-88-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, belongs to piperidines compound. In a article, author is Luo, Xiaoyu, introduce new discover of the category.

Curcumin-loaded electrospun nonwoven as a colorimetric indicator for volatile amines

Colorimetric indicators are useful in intelligent food packaging applications. As a natural food colorant, curcumin is a promising colorimetric indicator for the detection of alkaline compounds produced during food spoilage. In this study, curcumin-loaded electrospun nonwovens were developed for the detection of amines, which are principal spoilage volatiles of fish and aquatic products. The spin dope solution for electrospinning was prepared by dispersing curcumin (0.32% w/w) in 14% (w/w) polyvinylpyrrolidone (PVP) or 9% (w/w) ethylcellulose (EC)/0.2% (w/w) poly(ethylene oxide) (PEO) solution in anhydrous ethanol. Curcumin-loaded nonwovens were obtained by free surface electrospinning and subsequently characterized for amine detection. When exposed to amine volatiles, the nonwoven indicators exhibited striking yellow-to-orange/red color transition, along with a reduction in curcumin’s fluorescence intensity. Both EC/PEO- and PVP-based nonwovens were capable of discriminating six different volatile amines (trimethylamine, ammonia, dimethylamine, trie-thylamine, piperidine and hydrazine) at 0.2 mmol level. Comparing the two nonwoven carriers, EC/PEO resulted in smaller fiber diameter (1.06 mu m) and higher curcumin loading efficiency (91%) than those derived from PVP (83% loading efficiency and 1.52 mu m diameter). The limit of detection (LOD) and limit of quantitation (LOQ) of using EC/PEO-based fiber for amine detection were lower than PVP-based fiber, except for TMA.

Synthetic Route of 2403-88-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2403-88-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 2403-88-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, SMILES is CC1(C)CC(O)CC(C)(C)N1, belongs to piperidines compound. In a article, author is Morissette, Marie-France, introduce new discover of the category.

Trace level determination of chloroacetyl chloride and degradation products by derivatization gas chromatography

A gas chromatographic procedure has been developed for the trace determination of chloroacetyl chloride (CAC) and two of its impurities: methyl chloroacetate (MCA) and chloroacetic acid (CAA). All three compounds are derivatized using piperidine in dichioroethane prior to their analysis via gas chromatography coupled with a flame ionization detection (GC-FID). Recoveries of each compound were assessed in two different pharmaceutical matrices (intermediate and final active pharmaceutical ingredient) and ranged from 75 to 125%. The limit of quantitation has been determined to be 0.10% wt/wt for CAA and 0.03% wt/wt for CAC and MCA. The linearity ranged from 0.03 to 5.00% wt/wt for CAC and MCA and from 0.10 to 5.00% wt/wt for CAA, with correlation coefficients from 0.9995 to 1.0000. Repeatability was evaluated at LOQ and at 5.00% wt/wt and was found to be between 1.4-3.0%. (C) 2017 Elsevier B.V. All rights reserved.

Synthetic Route of 2403-88-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2403-88-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 2403-88-5, Name is 2,2,6,6-Tetramethyl-4-piperidinol, molecular formula is C9H19NO, belongs to piperidines compound, is a common compound. In a patnet, author is Raj, N. Ugin Inba, once mentioned the new application about 2403-88-5, SDS of cas: 2403-88-5.

Synthesis, single crystal XRD and CT DNA/BSA binding studies of new paracetamol derivatives

N-(4-hydroxy-3-(morpholino(phenyl)methyl)phenyl) acetamide and N-(4-hydroxy-3-(piperidin-1-yl(phenyl)methyl)phenyl) acetamide derivatives have been synthesized via three component reaction of paracetamol, morpholine/piperidine and benzaldehyde. The reaction afforded these novel paracetamol derivatives in moderate to good yield. The solid state structures of some compounds were examined by X-rays from single crystals.The DNA-binding interactions of the compounds with calf thymus DNA have been studied by UV, visible, emission studies. The results were observed hypochromism with red shift suggesting that compounds interact with CT DNA via intercalation. The protein-binding interactions of the compounds with BSA were examined by fluorescence, synchronous fluorescence and UV, visible spectroscopic methods. All the compounds have the ability to bind strongly with BSA and a static quenching mechanism was observed. (C) 2020 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 2403-88-5. The above is the message from the blog manager. SDS of cas: 2403-88-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem