Category: 23794-15-2

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 23794-15-2, is researched, Molecular C7H6ClNO, about Synthesis of some biologically active 2,4′-bipyridine-5-carbonitriles carrying the 4-hydroxyphenylthio moiety, the main research direction is bipyridine carbonitrile hydroxyphenylthio preparation antibacterial fungicide structure activity relationship.Reference of 1-(2-chloropyridine-4-yl)ethanone.

The reaction of 4-hydroxythiophenol with 4-acetyl-2-chloropyridine yielded a key intermediate, 1-{2-[(4-hydroxyphenyl)thio]pyridin-4-yl}ethanone. Further treatment of the key intermediate with Et cyanoacetate and various aromatic aldehydes in the presence of ammonium acetate furnished 4-aryl-2′-[(4-hydroxyphenyl)thio]-6-oxo-1,6-dihydro-2,4′-bipyridine-5-carbonitriles, e.g., I (R = H, MeO, Ph, Cl, Me2N). On the other hand, condensation of the key intermediate with aromatic aldehydes and malononitrile in the presence ammonium acetate of in alc. gave 6-amino-4-aryl-2′-[(4-hydroxyphenyl)thio]-2,4′-bipyridine-5-carbonitriles. All the title compounds were subjected to in vitro antibacterial testing against two strains and antifungal screening against two fungi. Some of the compounds showed promising activity.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Shu, Xiaomin; Jin, Ronghua; Zhao, Zhongrui; Cheng, Tanyu; Liu, Guohua published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Safety of 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

Herein, by utilized hollow-shell-structured silica, hydrogen-bonding immobilization via a ship-in-a-bottle synthesis locks a Pd(carbene) center in a nanocage and covalent-bonding immobilization tethers chiral Ru(diamine) centers within the nanochannels, constructed a hetero-bifunctional catalyst. The benefit of this dual center manipulation enabled a challenging Suzuki coupling-asym. transfer hydrogenation tandem reaction and the advantage of this process provided various chiral biarylols I [Ar = Ph, 3-MeC6H4, 3-thienyl, etc.] with enhanced reactivity and enantioselectivity.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

LaMattina, John L. published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Recommanded Product: 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines I (R = NH2, NHEt, NMe2; R1 = H, Me; R2 = H, NH2, Me), potential histamine H2 antagonists, is based on the Neber rearrangement of 1-(4-pyridyl)-1-alkanone oxime O-tosylates to α-amino ketones or α-amino ketals, which are then converted to the imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of Cl by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.

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Piperidine – Wikipedia,
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Reference of 1-(2-chloropyridine-4-yl)ethanone. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4). Author is Trofymchuk, Serhii; Bugera, Maksym; Klipkov, Anton A.; Ahunovych, Volodymyr; Razhyk, Bohdan; Semenov, Sergey; Boretskyi, Andrii; Tarasenko, Karen; Mykhailiuk, Pavel K..

A general approach to fluorinated (hetero)aromatic derivatives was elaborated. The key reaction was a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation was fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chem. and agrochem., were synthesized.

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Piperidine – Wikipedia,
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Sorna, Venkataswamy; Theisen, Emily R.; Stephens, Bret; Warner, Steven L.; Bearss, David J.; Vankayalapati, Hariprasad; Sharma, Sunil published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Reference of 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

Lysine specific demethylase 1 (LSD1) plays an important role in regulating histone lysine methylation at residues K4 and K9 on histone H3 and is an attractive therapeutic target in multiple malignancies. Here we report a structure-based virtual screen of a compound library containing ∼2 million small mol. entities. Computational docking and scoring followed by biochem. screening led to the identification of a novel N’-(1-phenylethylidene)-benzohydrazide series of LSD1 inhibitors with hits showing biochem. IC50s in the 200-400 nM range. Hit-to-lead optimization and structure-activity relation studies aided in the discovery of compound (I), with a Ki of 31 nM. Compound I is reversible and specific for LSD1 as compared to the monoamine oxidases shows minimal inhibition of CYPs and hERG and inhibits proliferation and survival in several cancer cell lines, including breast and colorectal cancer. Compound I may be used to probe LSD1’s biol. role in these cancers.

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Reference:
Piperidine – Wikipedia,
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Name: 1-(2-chloropyridine-4-yl)ethanone. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Iron-Catalyzed Arylation of Heterocycles via Directed C-H Bond Activation. Author is Sirois, John J.; Davis, Riley; DeBoef, Brenton.

The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0°. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions, published in 2021-09-03, which mentions a compound: 23794-15-2, Name is 1-(2-chloropyridine-4-yl)ethanone, Molecular C7H6ClNO, Recommanded Product: 23794-15-2.

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads, Author is Rombouts, Frederik J. R.; Tresadern, Gary; Delgado, Oscar; Martinez-Lamenca, Carolina; Van Gool, Michiel; Garcia-Molina, Aranzazu; Alonso de Diego, Sergio A.; Oehlrich, Daniel; Prokopcova, Hana; Alonso, Jose Manuel; Austin, Nigel; Borghys, Herman; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Alexander, Richard; Macdonald, Gregor; Moechars, Dieder; Gijsen, Harrie; Trabanco, Andres A., which mentions a compound: 23794-15-2, SMILESS is CC(=O)C1=CC(Cl)=NC=C1, Molecular C7H6ClNO, Quality Control of 1-(2-chloropyridine-4-yl)ethanone.

1,4-Oxazines are presented, which show good in vitro inhibition in enzymic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permitted modulation of properties such as permeation and especially P-glycoprotein efflux. This led to compounds which were orally bioavailable, centrally active, and which demonstrated robust lowering of brain and CSF Aβ levels, resp., in mouse and dog models. The amyloid lowering potential of these mols. makes them valuable leads in the search for new BACE1 inhibitors for the treatment of Alzheimer’s disease.

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Piperidine – Wikipedia,
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Formula: C7H6ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. Author is Ansideri, Francesco; Macedo, Joana T.; Eitel, Michael; El-Gokha, Ahmed; Zinad, Dhafer S.; Scarpellini, Camilla; Kudolo, Mark; Schollmeyer, Dieter; Boeckler, Frank M.; Blaum, Baerbel S.; Laufer, Stefan A.; Koch, Pierre.

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity from the original target p38α MAPK to the closely related JNK3. In particular, a significant improvement for JNK3 selectivity could be achieved by addressing the hydrophobic region I with a small Me group. Furthermore, addnl. structural modifications permitted to explore structure-activity relationships. The most potent inhibitor 4-(4-methyl-2-(methylthio)-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyridin-2-amine showed an IC50 value for the JNK3 in the low triple digit nanomolar range and its binding mode was confirmed by x-ray crystallog.

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Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, anticonvulsant activity and QSAR studies of some new pyrazolyl pyridines, published in 2016-08-31, which mentions a compound: 23794-15-2, mainly applied to anticonvulsant epilepsy QSAR pyrazole pyridine, Safety of 1-(2-chloropyridine-4-yl)ethanone.

Twenty-one new 3,5-bipyridinyl-1H-pyrazole derivatives (pyrazolyl pyridines) have been synthesized and evaluated for their anticonvulsant activity in animal models of epilepsy. The pyrazolyl pyridines I [R1 = H, Cl, Ph, etc.; R2 = H, Cl, Ph, etc.] were obtained through a general one-pot synthesis, from ketones and acid chlorides via formation of 1,3-diketones in situ carried out in hydrocarbon solvent and LiHMDS base. The profile of anticonvulsant activity of final compounds was established in the maximal electroshock (MES) and s.c. pentylenetetrazole (s.c. PTZ) tests, after i.p. injection in rats and mice, resp., at doses of 30, 100, and 300 mg/kg. An observation was carried out at two different time intervals-0.5 and 4 h. Phenytoin was used as a standard antiepileptic against MES convulsions and valproic acid against s.c. PTZ convulsions. Furthermore, in addition to the primary anticonvulsant screening, the acute neurol. toxicity was determined in mice by the rotarod test and in rats by positional sense test. The compounds showed anticonvulsant activity exclusively against MES convulsions. The compounds were found especially active in 100 mg/kg dose at both the time points, i.e., 0.5 and 4 h, depending upon the lipophilicity of mols. as indicated by statistically significant reduction in the time spent in tonic extension phase (p < 0.001). Further, the newly synthesized compounds were subjected to two-dimensional quant. structure-activity relationship (2D QSAR) anal. through multiple linear regression, principal component regression, and partial least square regression anal., and three-dimensional quant. structure-activity relationship (3D QSAR) anal. by k-nearest neighbor mol. field anal. in conjunction with stepwise forward-backward, genetic algorithm, and simulated annealing variable selection methods using the software VLife MDS. The structure-activity relationship (SAR) as well as quant. structure-activity relationship (QSAR) studies for anticonvulsant activity confirmed the crucial role of 3,5-bipyridinyl-1H-pyrazole core fragment for anticonvulsant activity. As far as I know, this compound(23794-15-2)Safety of 1-(2-chloropyridine-4-yl)ethanone can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem