Category: 23794-15-2

Bellale, Eknath; Naik, Maruti; Varun, V. B.; Ambady, Anisha; Narayan, Ashwini; Ravishankar, Sudha; Ramachandran, Vasanthi; Kaur, Parvinder; McLaughlin, Robert; Whiteaker, James; Morayya, Sapna; Guptha, Supreeth; Sharma, Sreevalli; Raichurkar, Anandkumar; Awasthy, Disha; Achar, Vijayshree; Vachaspati, Prakash; Bandodkar, Balachandra; Panda, Manoranjan; Chatterji, Monalisa published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Quality Control of 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chem. exploration, the authors demonstrated chem. opportunities to optimize the potency and physicochem. properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochem. properties. The potent antimycobacterial activity, in conjunction with low mol. weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational anal. showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.

This compound(1-(2-chloropyridine-4-yl)ethanone)Quality Control of 1-(2-chloropyridine-4-yl)ethanone was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Product Details of 23794-15-2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. Author is Green, Jeremy; Cao, Jingrong; Bandarage, Upul K.; Gao, Huai; Court, John; Marhefka, Craig; Jacobs, Marc; Taslimi, Paul; Newsome, David; Nakayama, Tomoko; Shah, Sundeep; Rodems, Steve.

The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with cellular motility, morphol., and contraction and are of therapeutic interest in diseases associated with cellular migration and contraction, such as hypertension, glaucoma, and erectile dysfunction. Beginning with compound 4, an inhibitor of ROCK1 identified through high-throughput screening, systematic exploration of SAR, and application of structure-based design, led to potent and selective ROCK inhibitors. Compound 37 represents significant improvements in inhibition potency, kinase selectivity, and CYP inhibition and possesses pharmacokinetics suitable for in vivo experimentation.

This compound(1-(2-chloropyridine-4-yl)ethanone)Product Details of 23794-15-2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation, published in 2021-03-29, which mentions a compound: 23794-15-2, mainly applied to semipinacol azetidine preparation strain release rearrangement azabicyclo Bu carbinol; spiroepoxy azetidine divergent preparation strain release nucleophilic ring expansion; azabicyclo[1.1.0]butane; azetidines; epoxides; ring expansion; strained molecules, Application In Synthesis of 1-(2-chloropyridine-4-yl)ethanone.

The azetidine moiety is a privileged motif in medicinal chem. and new methods that access them efficiently are highly sought after. Towards this goal, we have found that azabicyclo[1.1.0]butyl carbinols, readily obtained from the highly strained azabicyclo[1.1.0]butane (ABB), can undergo divergent strain-release reactions upon N-activation. Treatment with trifluoroacetic anhydride or triflic anhydride triggered a semipinacol rearrangement to give keto 1,3,3-substituted azetidines. More than 20 examples were explored, enabling us to evaluate selectivity and the migratory aptitude of different groups. Alternatively, treatment of the same alcs. with benzyl chloroformate in the presence of NaI led to iodohydrin intermediates which gave spiroepoxy azetidines upon treatment with base. The electronic nature of the activating agent dictates which pathway operates.

《Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-(2-chloropyridine-4-yl)ethanone)Application In Synthesis of 1-(2-chloropyridine-4-yl)ethanone.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Identification of pyrimidine derivatives as hSMG-1 inhibitors, published in 2012-11-01, which mentions a compound: 23794-15-2, mainly applied to pyrimidine derivative preparation structure SMG1 kinase inhibitor cancer, SDS of cas: 23794-15-2.

HSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. From our screening efforts, we have identified pyrimidine derivatives as hSMG-1 kinase inhibitors. We report structure-based optimization of this pan-kinase scaffold to improve its biochem. profile and overall kinome selectivity, including mTOR and CDK, to generate the first reported selective hSMG-1 tool compound

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chowdhury, Morshed A.; Abdellatif, Khaled R. A.; Dong, Ying; Das, Dipankar; Suresh, Mavanur R.; Knaus, Edward E. researched the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2 ).Safety of 1-(2-chloropyridine-4-yl)ethanone.They published the article 《Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity》 about this compound( cas:23794-15-2 ) in Journal of Medicinal Chemistry. Keywords: dihydropyridone difluoromethyl derivative preparation cyclooxygenase lipoxygenase inhibition antiinflammatory activity; celecoxib analog preparation cyclooxygenase lipoxygenase dual inhibition antiinflammatory activity. We’ll tell you more about this compound (cas:23794-15-2).

A novel class of hybrid cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LOX) inhibitory anti-inflammatory agents I (R = Me, NH2) was designed. Replacement of the tolyl ring present in celecoxib by the N-difluoromethyl-1,2-dihydropyrid-2-one moiety provided compounds showing dual selective COX-2/5-LOX inhibitory activities. Sulfonamide I (R = NH2) exhibited good anti-inflammatory (AI) activity (ED50 = 27.7 mg/kg po) that compares favorably with the reference drugs celecoxib (ED50 = 10.8 mg/kg po) and ibuprofen (ED50 = 67.4 mg/kg po). The N-difluoromethyl-1,2-dihydropyrid-2-one moiety provides a novel 5-LOX pharmacophore for the design of cyclic hydroxamic mimetics for exploitation in the development of COX-2/5-LOX inhibitory AI drugs.

Different reactions of this compound(1-(2-chloropyridine-4-yl)ethanone)Safety of 1-(2-chloropyridine-4-yl)ethanone require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2 ) is researched.HPLC of Formula: 23794-15-2.Mayekar, Anil N.; Li, Hongqi; Yathirajan, H. S.; Narayana, B.; Kumari, N. Suchetha published the article 《Synthesis, characterization and antimicrobial study of some new cyclohexenone derivatives》 about this compound( cas:23794-15-2 ) in International Journal of Chemistry (Toronto, ON, Canada). Keywords: antimicrobial single crystal XRD chalcone cyclohexenone derivative MSBAR. Let’s learn more about this compound (cas:23794-15-2).

A series of chalcones and its cyclohexenone derivatives derived from 6-methoxy-2-naphthaldehyde are described. The chalcones synthesized through Claisen-Schmidt condensation reaction were treated with ethylacetoacetate in presence of NaOH to get the cyclocondensed product ethyl-4-(aryl)-6-(6-methoxy-2-naphthyl)-2-oxo-cyclohex-3-ene-1-carboxylate. The synthesized compounds were characterized from elemental anal. and spectral data. Et 4-(4-chlorophenyl)-6-(6-methoxy-2-naphthyl)-2-oxo-cyclohex-3-ene-1-carboxylate was studied by single crystal X-ray diffraction. The newly synthesized compounds were screened for their antimicrobial activity.

The article 《Synthesis, characterization and antimicrobial study of some new cyclohexenone derivatives》 also mentions many details about this compound(23794-15-2)HPLC of Formula: 23794-15-2, you can pay attention to it, because details determine success or failure

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23794-15-2, is researched, SMILESS is CC(=O)C1=CC(Cl)=NC=C1, Molecular C7H6ClNOPreprint, bioRxiv called Generation of strong casein kinase 1 inhibitor of Arabidopsis thaliana, Author is Saito, Ami N.; Matsuo, Hiromi; Kuwata, Keiko; Ono, Azusa; Kinoshita, Toshinori; Yamaguchi, Junichiro; Nakamichi, Norihito, the main research direction is Arabidopsis casein kinase inhibitor eukaryote.Computed Properties of C7H6ClNO.

Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase among eukaryotes. Studies on yeast, fungi, and animals have revealed that CK1 plays roles in divergent biol. processes. By contrast, the collective knowledge regarding the biol. roles of plant CK1 lags was behind those of animal CK1. One of reasons for this is that plants have more multiple genes encoding CK1 than animals. To accelerate the research for plant CK1, a strong CK1 inhibitor that efficiently inhibits multiple members of CK1 proteins in vivo (in planta) is required. Here, we report a novel strong CK1 inhibitor of Arabidopsis (AMI-331). Using a circadian period-lengthening activity as estimation of the CK1 inhibitor effect in vivo, we performed a structure-activity relationship (SAR) study of PHA767491 (1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride), a potent CK1 inhibitor of Arabidopsis, and found that PHA767491 analogs bearing a propargyl group at the pyrrole nitrogen atom (AMI-212) or a bromine atom at the pyrrole C3 position (AMI-23) enhance the period-lengthening activity. The period lengthening activity of a hybrid mol. of AMI-212 and AMI-23 (AMI-331) is about 100-fold stronger than that of PHA767491. An in vitro assay indicated a strong inhibitory activity of CK1 kinase by AMI-331. Also, affinity proteomics using an AMI-331 probe showed that targets of AMI-331 are mostly CK1 proteins. As such, AMI-331 is a strong potent CK1 inhibitor that shows promise in the research of CK1 in plants.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2).Formula: C7H6ClNO.

A new class of potent kinase inhibitors selective for mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) for the treatment of rheumatoid arthritis has been prepared and evaluated. These inhibitors have IC50 values as low as 10 nM against the target and have good selectivity profiles against a number of kinases including CDK2, ERK, JNK, and p38. These MK-2 inhibitors have been shown to suppress TNFα production in U937 cells and to be efficacious in an acute inflammation model. The structure-activity relationships of this series, the selectivity for MK-2 and their activity in both in vitro and in vivo models are discussed. The observed selectivity is discussed with the aid of an MK-2/inhibitor crystal structure.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Quality Control of 1-(2-chloropyridine-4-yl)ethanone. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Synthesis of some new 4-(2-chloropyridin-4-yl)-N-aryl-1,3-thiazol-2-amine derivatives as possible antifungal and antibacterial agents. Author is Narayana, B.; Raj, K. K. Vijaya; Ashalatha, B. V.; Kumari, N. Suchetha.

Novel 4-(2-chloropyridin-4-yl)-N-aryl-1,3-thiazol-2-amines were prepared by reacting (4-bromoacetyl)-2-chloropyridine with thiourea and substituted thioureas. The newly synthesized compounds were characterized by anal. and spectral data. All the compounds were screened for their antifungal and antibacterial activities. Almost all the compounds possess excellent antifungal and antibacterial activities.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Alvey, Luke; Prado, Soizic; Huteau, Valerie; Saint-Joanis, Brigitte; Michel, Sylvie; Koch, Michel; Cole, Stewart T.; Tillequin, Francois; Janin, Yves L. published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Reference of 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

From the structure of 3,3-dimethyl-3H-benzofuro[3,2-f][1]-benzopyran, a selective in vitro inhibitor of mycobacterial growth, a structure-activity relationship investigation has been undertaken. Reported here are the results on the use of [2+3] cycloadditions between 2-formylbenzoquinone and various enol derivatives to give various 4-formyl-5-hydroxy benzofurans. In the next step, an ytterbium triflate-catalyzed reaction with 2-methylpropene allowed the preparation of various original furo[3,2-f]chromenes derivatives Their biol. evaluation on the growth of Mycobacterium smegmatis as well as Mycobacterium tuberculosis pointed out that some analogs were four times more active than the initial hit.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem