Category: 22990-34-7

Some tips on 22990-34-7

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

22990-34-7, 2-(4-Piperidyl)-2-propanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 209 [0728] cis-Methyl 4-((E)-2-(4-fluorobenzoylimino)-6-((4-(2- hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate. To a 0C cooled solution of cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate (1 g, 2.350 mmol) in DCM (25 mL) was added thionyl chloride (0.858 mL, 11.75 mmol) dropwise, and the reaction was stirred at 0C for 30 minutes. After 30 minutes, the solvent was removed at reduced pressure, and the residue was suspended in ACN (5 mL) and re-concentrated to remove residual thionyl chloride. The residue was resuspended in ACN (15 mL), cooled to 0C, and 2-(piperidin-4- yl)propan-2-ol (1.010 g, 7.05 mmol) and TEA (0.655 mL, 4.70 mmol) were added. The reaction was stirred overnight at RT. After 16 hours, the reaction mixture was concentrated and partitioned between EtOAc and water. The organic layer was concentrated and the residual product was purified by column chromatography, eluting with 0-100% (90:9:1 DCM/MeOH/NH4OH)/DCM to provide cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-((4-(2-hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro- lH-benzo[d]imidazol-l-yl)cyclohexanecarboxylate as a white powder (1.05 g, 81 % yield). .H NMR (400 MHz, DMSO-d6) delta ppm 1.03 (s, 6 H), 1.09 – 1.35 (m, 3 H), 1.56 – 1.91 (m, 8 H), 2.21 – 2.29 (m, 2 H), 2.53 – 2.64 (m, 2 H), 2.77 – 2.95 (m, 3 H), 3.50 (s, 2 H), 3.77 (s, 3 H), 3.99 (s, 1 H), 4.74 (br. s., 1 H), 7.14 (d, J=6.9 Hz, 1 H), 7.26 (dd, J=8.8 Hz, 8.8 Hz, 2 H), 7.37 – 7.58 (m, 2 H), 8.26 (dd, J=8.7, 5.9 Hz, 2 H), 12.77 (s, 1 H). MS, m/z (C31H39FN4O4): calcd, 550.3; found, 551.1 [M+H].

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; BODE, Christiane, M.; CHENG, Alan, C.; CHOQUETTE, Deborah; LEWIS, Richard, T.; POTASHMAN, Michele, H.; ROMERO, Karina; STELLWAGEN, John, C.; WHITTINGTON, Douglas, A.; WO2012/18668; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Some tips on 22990-34-7

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

22990-34-7, 2-(4-Piperidyl)-2-propanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 209 [0728] cis-Methyl 4-((E)-2-(4-fluorobenzoylimino)-6-((4-(2- hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate. To a 0C cooled solution of cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate (1 g, 2.350 mmol) in DCM (25 mL) was added thionyl chloride (0.858 mL, 11.75 mmol) dropwise, and the reaction was stirred at 0C for 30 minutes. After 30 minutes, the solvent was removed at reduced pressure, and the residue was suspended in ACN (5 mL) and re-concentrated to remove residual thionyl chloride. The residue was resuspended in ACN (15 mL), cooled to 0C, and 2-(piperidin-4- yl)propan-2-ol (1.010 g, 7.05 mmol) and TEA (0.655 mL, 4.70 mmol) were added. The reaction was stirred overnight at RT. After 16 hours, the reaction mixture was concentrated and partitioned between EtOAc and water. The organic layer was concentrated and the residual product was purified by column chromatography, eluting with 0-100% (90:9:1 DCM/MeOH/NH4OH)/DCM to provide cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-((4-(2-hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro- lH-benzo[d]imidazol-l-yl)cyclohexanecarboxylate as a white powder (1.05 g, 81 % yield). .H NMR (400 MHz, DMSO-d6) delta ppm 1.03 (s, 6 H), 1.09 – 1.35 (m, 3 H), 1.56 – 1.91 (m, 8 H), 2.21 – 2.29 (m, 2 H), 2.53 – 2.64 (m, 2 H), 2.77 – 2.95 (m, 3 H), 3.50 (s, 2 H), 3.77 (s, 3 H), 3.99 (s, 1 H), 4.74 (br. s., 1 H), 7.14 (d, J=6.9 Hz, 1 H), 7.26 (dd, J=8.8 Hz, 8.8 Hz, 2 H), 7.37 – 7.58 (m, 2 H), 8.26 (dd, J=8.7, 5.9 Hz, 2 H), 12.77 (s, 1 H). MS, m/z (C31H39FN4O4): calcd, 550.3; found, 551.1 [M+H].

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; BODE, Christiane, M.; CHENG, Alan, C.; CHOQUETTE, Deborah; LEWIS, Richard, T.; POTASHMAN, Michele, H.; ROMERO, Karina; STELLWAGEN, John, C.; WHITTINGTON, Douglas, A.; WO2012/18668; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Brief introduction of 22990-34-7

22990-34-7 2-(4-Piperidyl)-2-propanol 5200321, apiperidines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22990-34-7,2-(4-Piperidyl)-2-propanol,as a common compound, the synthetic route is as follows.,22990-34-7

(a) A/-(2,2,2-Trifluoroethyl)-2-[4-(1-hydroxy-1-methyl-ethyl)-piperidinyl]-4-methy nitro-benzoic acid amideA mixture of 4-(1-hydroxy-1-methyl-ethyl)-piperidine (24 mg, 0.17 mmol), NaH-suspension (50% in mineral oil, 8 mg, -0.17 mmol) and THF (1 ml_) is stirred for 10 min. Then, Lambda/-(2,2,2- trifluoro-ethyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide is added and it is stirred for 1.5 h. The mixture is diluted with EtOAc, washed with water, concentrated, dried and directly used in the next step.HPLC Rt = 1.34 min (method A). MS m/z: 419 [M+H]+.

22990-34-7 2-(4-Piperidyl)-2-propanol 5200321, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PRIEPKE, Henning; DOODS, Henri; HEIM-RIETHER, Alexander; KUELZER, Raimund; PFAU, Roland; RUDOLF, Klaus; STENKAMP, Dirk; WO2012/76673; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem