Category: 223632-64-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.223632-64-2,1-(3-Chloro-4-fluorobenzoyl)piperidin-4-one,as a common compound, the synthetic route is as follows.

To a solution of 1-[(3-chloro-4-fluorophenyl) carbonyl] piperidin-4-one [Example 1, Step 2] (2 g, 7.8 mmol, 1.00 equiv) in dichloromethane (20 mL) was added sodium hydroxide (30.5% in H2O) (5.4 mL, 7.00 equiv), TBAC (108 mg, 0.38 mmol, 0.05 equiv) and 2-chloroacetonitrile (1.18 g, 15.6 mmol, 2.00 equiv) at 0 C. The reaction solution was stirred for 1 h at room temperature. The resulting solution was diluted with water (100 mL). The resulting solution was extracted with dichloromethane (3×100 mL). The organic layers were washed with brine (3×50 mL). The mixture was dried over anhydrous sodium sulfate and concentrated under vacuum to afford 1.1 g (48%) of 6-[(3-chloro-4-fluorophenyl)carbonyl]-1-oxa-6-azaspiro[2.5]octane-2-carbonitril as a brown solid. LC-MS: m/z=295[M+H]+., 223632-64-2

223632-64-2 1-(3-Chloro-4-fluorobenzoyl)piperidin-4-one 10611056, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Auspex Pharmaceuticals, Inc.; ZHANG, Chengzhi; (94 pag.)US2018/79742; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

223632-64-2, 1-(3-Chloro-4-fluorobenzoyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 6-(3-Chloro-4-fluorobenzoyl)-1-oxa-6-azaspiro[2.5]octane-2-carbonitrile (V). A suspension of 1-(3-chloro-4-fluorobenzoyl)piperidin-4-one (4160 g, 16.27 mol) in 28.4 liters of dichloromethane and 11.7 liters of sodium hydroxide at 30.5%, supplemented with 186 g of tetrabutylammonium chloride, is cooled to 15 C. chloroacetonitrile (1540 ml, 24.4 mol) is then added slowly and with vigorous stirring and the mixture is stirred for 3 hours at 20 C. Further addition of chloroacetonitrile (500 ml) is carried out in order to complete the reaction.The reaction medium is diluted with dichloromethane (8.5 liters) and water (20 liters) and then separated by decantation and washed again with water.The brown solution obtained is decolorized with 2 kg of silica and 500 g of animal charcoal and then evaporated to dryness.The residue obtained is crystallized from isopropanol in order to give, after filtration, 3426 g of brown crystals. m.p.=100-101 C., 223632-64-2

As the paragraph descriping shows that 223632-64-2 is playing an increasingly important role.

Reference：
Patent; Maurel, Jean-Louis; Bonnaud, Bernard; Ribet, Jean-Paul; Vacher, Bernard; US2004/116705; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem