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This invention relates to imidazole compounds which are useful in promoting smoking cessation and maintaining abstinence.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H619N – PubChem

 

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The synthesis and pharmacological profile of several cyano (1a-e) and carboxamido (2a-h) side-chain-substituted analogues of 1′,1′-dimethyl-Delta8- THC are described. Commercially available cyano compound 3 was transformed to the resorcinol 6 in a three-step sequence. Condensation of 6 with p-menth-2- ene-1,8-diol formed the THC 7a which, with sodium cyanide/DMSO, gave 1b. Protection of the phenol in 7a as the MOM derivative provided the common intermediate 8 for the synthesis of 1a,c,e. Compound 1d was also synthesized from 7a via the aldehyde 9a. Base hydrolysis of 1b gave the acid 10 which, via its acid chloride and subsequent treatment with the appropriate amine, formed the target compounds 2a-h. The pharmacological profile indicated that the cyano analogues 1a-e had very high CB1 binding affinity (0.36-13 nM) and high in vivo potency as agonists. Two analogues (1a,b) had extremely high potency in the mouse tetrad tests. The dimethylcarboxamido analogue 2a showed a similar profile to 1a,b. The high potency was also retained in analogue 2c. In contrast the sulfonamide analogue 2d was unique as it had greater affinity than Delta9-THC, yet it was practically devoid of agonist effects. This study suggests that the incorporation of a cyano or an amide substituent in the side chain of Delta8-THC-DMH can enhance potency and can also lead to compounds with a unique profile which have high binding affinity and are practically devoid of agonist effects.

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Piperidine – Wikipedia,
Piperidine | C5H651N – PubChem

 

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Since their discovery in the 1960s, cytochrome P450-dependent monooxygenases have very much attracted the interest of chemists because of their ability to catalyze the selective transfer of an oxygen atom from O2 to very diverse substrates including alkanes. The huge number of studies performed during these last 30 years on P450s themselves and on iron porphyrin models has led to a detailed understanding of the oxidations catalyzed by iron porphyrins and hemeproteins in general, and to the design of many bioinspired oxidation catalysts. This article gives an overview of what were the main contributions of metalloporphyrin model studies to the fields of P450 chemistry and oxidation catalysis, through a brief comparative history of the development of our knowledge on cytochrome P450 and on the development and use of metalloporphyrin models.

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Piperidine – Wikipedia,
Piperidine | C5H854N – PubChem

 

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A series of non-peptidergic antagonists of NPY have been synthesized and are comprises of amino and piperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. 1where X is CH or N As antagonists of NPY-induced behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

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Piperidine – Wikipedia,
Piperidine | C5H1062N – PubChem

 

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Synthetic Route of 2213-43-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-43-6, Name is 1-Aminopiperidine, molecular formula is C5H12N2. In a Patent,once mentioned of 2213-43-6

Salts of 1,2-diarylimidazole-4-carboxamides and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.

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Piperidine – Wikipedia,
Piperidine | C5H862N – PubChem

 

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The reduction of selected nitrosamines by aqueous TiCl3 has been investigated.In general, aliphatic nitrosamines were converted in good yield to the corresponding hydrazines, with little overreduction to the amines.Reaction proceeded rapidly at room temperature in both alkaline and acidic media.A variety of N,N-dialkylhydrazines have been isolated by using the TiCl3 method, which compares favorably with previously reported procedures for preparatively converting nitrosamines to hydrazines.In the reduction of N-nitroso-N-methylaniline, the proportion of amine in the product increased significantly as the pH of the reaction mixture was lowered, presumably reflecting the known instability of arylalkylnitrosamines in strong acid, coupled with a ready reducibility of the corresponding Fischer-Hepp intermediates; some tendency toward reductive cleavage of the N-aryl-N-alkylhydrazine’s N-N-bond was also noted.Reduction of an alpha-nitrosamino ether gave the monoalkylhydrazine as the major product, while all other reducing agents studied converted this starting material chiefly to a mixture of primary and secondary amines.

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Piperidine – Wikipedia,
Piperidine | C5H660N – PubChem

 

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[Problem] in plant disease resistance-inducing gene expression found thienopyrimidine derivative effect, utilizing the thienopyrimidine derivatives, injuries to plant disease organisms[Solution] some of the thienopyrimidine derivatives, such as gene expression in a plant disease-resistance gene to induce PR-a 1, therefore cruciferous vegetables against plant diseases caused by pathogenic bacillus anthracis, exhibiting excellent control effect was found. [Drawing] no (by machine translation)

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Piperidine – Wikipedia,
Piperidine | C5H1146N – PubChem

 

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Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of: 1-Aminopiperidine. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 2213-43-6

The present invention relates to compounds of formula I or salts thereof, wherein, R1 is selected from the group consisting of hydrogen and R4; R2 is selected from the group consisting of hydrogen, acetyl and R4; R3 is selected from the group consisting of alkyl, ?O-alkyl, ?NH-alkyl, aryl and heterocyclyl; R4 represents a moiety (A) wherein, X is selected from the group consisting of a single bond, alkylene, alkenylene, alkynylene, arylene or a heterocyclylene moiety; R5 and R6 are same or different and are independently selected from hydrogen, alkyl, aryl or heterocyclyl; or R5 and R6 may form together with the nitrogen atom to which they are attached a heterocyclyl ring system.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H724N – PubChem

 

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 2213-43-6, molcular formula is C5H12N2, introducing its new discovery. Quality Control of: 1-Aminopiperidine

Colourless crystals of the carbonyl copper complex [(NH3)3(CO)Cu][Co(CO)4] (1a) are formed in the reaction of [Cu(NH3)4]Cl and Na[Co(CO)4] (T < -8C, pCO = 1 bar); above -5C and under N2-atmosphere 1a converts to [(NH3)2CuCo(CO)4] (C), which serves as a starting material for the synthesis of new copper cobaltates: the amines N-amino piperidine, N,N-dimethyl ethylenediamine (dmed) and N-benzyl N?,N?-dimethyl ethylenediamine (bn-dmed) replace NH3 to form [(C5H10N - NH2)3CuCo(CO)4] (1b), [(dmed)CuCo(CO)4] (1c), [(bn-dmed)CuCo(CO)4] (1d) the Cu - Co-bond remaining intact. [(NH3)2CuFe(CO)3NO] (2a) is isosteric with C; it is synthesized from [Cu(NH3)4]Cl and Na[Fe(CO)3NO] in aqueous solution; 2a reacts with N,N,N?,N?-tetramethyl ethylenediamine (tmed) to form [(tmed)(NH3)CuFe(CO)3NO] (2b). The [Mn(CO)5]- ion reacts with ammine copper ions to form the tetranuclear cluster [{(NH3)CuMn(CO)5}2] (3). All new compounds have been investigated by X-ray structure analysis. Johann Ambrosius Barth 1996. One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Quality Control of: 1-Aminopiperidine, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 2213-43-6

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Piperidine – Wikipedia,
Piperidine | C5H1008N – PubChem

 

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Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 2213-43-6. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 2213-43-6

Terminal alkynes react with secondary amines in the presence of TpRh(C2H4)2/PPh3 (Tp = trispyrazolylborate) to give anti-Markovnikov E-enamines. Both Tp and PPh3 ligands are essential for the reaction. The reaction tolerates functional groups, such as ester, nitrile, and siloxy groups, on the terminal alkynes. Primary amines also add to terminal alkynes in anti-Markovnikov fashion, yielding the corresponding imines. The formation of a vinylidene-rhodium complex followed by the intermolecular nucleophilic attack by an amine nitrogen at the alpha-carbon atom of the vinylidene-metal intermediate may be involved in a key step in the catalytic reaction. Copyright

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H838N – PubChem