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An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin alphavbeta3antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases:wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR4, >CR5R6, O, S, or -NR4-CR5R6-; X represents CH or N; R7and R8represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R9represents hydrogen, alkyl or the like; J represents a bond or alkylene; R10represents optionally substituted hydroxyl, amino or the like; R11represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H1035N – PubChem

 

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Aldehyde and ketone N,N-dialkylhydrazones behave as a stable class of imine surrogates exhibiting a unique reactivity in the Strecker reaction with in situ generated HCN, that proceeds in pure water in the absence of co-solvents, catalysts or promoters. Experimental evidence suggests that the reaction is assisted by an intramolecular activation of HCN by the dialkyl amino lone pair. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

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Piperidine – Wikipedia,
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Compounds of formula (I): wherein R1, R2, R3, R4, R5, and X are defined herein. Also disclosed are pharmaceutical compositions and methods related to use of these compounds.

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Piperidine – Wikipedia,
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N,N-Disubstituted hydrazines reacted with a mixture of a dialkylnitroxide and tetranitromethane to give nitrosamines and small amounts of hydrazones of dinitroformaldehyde.

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Piperidine – Wikipedia,
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N,N-Dialkyl-N?-arylhydrazines have been prepared usually in high to excellent yields via the reaction of N,N-dialkylhydrazines with aryl chlorides in the presence of Pd2(dba)3, Xphos and NaO-t-Bu in dioxane at 120C. With ortho-substituted aryl chlorides best results have been obtained by using 2-(2?,6?-dimethoxybiphenyl) dicyclohexylphosphine (ligand d) as the ligand.

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Piperidine – Wikipedia,
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A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance which is a pyrrole carboxamide compound of Formula I, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. Also claimed are stable dispersions obtainable by the process, solid particles obtainable by the process and use of such particles. The process provides a dispersion of solid particles in an aqueous medium, which particles exhibit reduced or substantially no particle growth mediated by Ostwald ripening. The process is particlularly suitable for the preparation of small (sub-micron) aqueous dispersions of a substantially water-insoluble pharmacologically active substance.

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Piperidine – Wikipedia,
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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 2213-43-6, molcular formula is C5H12N2, introducing its new discovery. Computed Properties of C5H12N2

The present invention relates to compounds of formula (I): in which R1 and R2 independently represent phenyl, thienyl or pyridyl and R3 represents a group-X-Y-NR4R5 in which X is CO or SO 2; Y is absent or represents NH and the other substituente are as defined in the description and their use in the treatment of obesity, psychiatric and neurological disorders and to pharmaceutical compositions containing them.

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Piperidine – Wikipedia,
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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2213-43-6 is helpful to your research. Product Details of 2213-43-6

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 2213-43-6, name is 1-Aminopiperidine, introducing its new discovery. Product Details of 2213-43-6

The synthesis of a series of azole antifungal compounds which incorporate the aminimide functional moiety is described. The procedure involves the reaction of an epoxide intermediate with 1,1-disubstituted hydrazines to form aminimines which are subsequently treated with acyl chlorides resulting in the desired switterionic aminimides. The aminimides were tested for in vitro antifungal activity and found to be moderately active against Candida and Cryptococcus species, but inactive versus Aspergillus.

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Piperidine – Wikipedia,
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Searching for novel antiobesity agents, a series of cannabinoid LH21 and of Rimonabant-fatty acid amide analogues have been prepared. Synthesis of pyrazoles 2a-2c was achieved by a two steps simple methodology via alpha,beta-unsaturated ketones. Carboxamides 8a-8h were obtained in good yields from esters 7a-7c by a one-pot procedure which takes place under mild conditions. New compounds have been evaluated in vivo as anorectic agents. Some of them showed interesting properties reducing food intake in rats by a mechanism which does not involve the endocannabinoid system.

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Piperidine – Wikipedia,
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Electric Literature of 2213-43-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2213-43-6, Name is 1-Aminopiperidine, molecular formula is C5H12N2. In a Article,once mentioned of 2213-43-6

Hydrazinolysis of the pentacarbonyl[alkyl- or aryl-(methoxy)carbene] complexes of W0 and Cr0 with both 1,1- and 1,2-disubstituted hydrazines affords the corresponding new hydrazinocarbenes 15-18, 21 and 22, and the presence of LiCl in the reaction medium greatly increases their yields.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H956N – PubChem