Category: 22065-85-6

22065-85-6, 1-Benzylpiperidine-4-carbaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 20 Production of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methylpiperidine using a mixed solvent of methanol and toluene and sodium hydroxide and adopting method A Into a 50-mL four-necked flask were charged 2.0 g (10.4 mmol) of 5,6-dimethoxy-1-indanone, 2.5 g (12.3 mmol, 1.2 equivalents) of 1-benzyl-4-formylpiperidine and 24 mL of a mixed solvent (methanol: toluene = 16: 14). After the air in the system was replaced with nitrogen, 0.5 g (12.5 mmol, 1.2 equivalents) of sodium hydroxide was added to the reaction solution with refluxing (65C). After completion of the addition, stirring was continued with refluxing for 1 hour to complete the reaction. Then, the reaction solution was air-cooled until crystals were precipitated. After the precipitation, the reaction solution was further cooled (cooling rate: 36C/hour) and the crystals precipitated at 4C or higher were collected by filtration. The crystals began to be precipitated at 49C. The crystals collected by filtration were washed with water (30 mL) and 6 mL of methanol and dried at 50C (drying time: 2 hours and 35 minutes) to obtain 3.31 g of the crystals of the title compound (yield: 84.3%). 1H-NMR data of these crystals agreed with those obtained in Example 1., 22065-85-6

22065-85-6 1-Benzylpiperidine-4-carbaldehyde 89584, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; EP1911745; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

22065-85-6, 1-Benzylpiperidine-4-carbaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-3) 1-Benzyl-4-[(5,6-diethoxy-1-indanon)-2-ylidene]methylpiperidine To a solution of 24.1 g of 5,6-diethoxy-1-indanone in 70 ml of THF was added 26.7 g of 1-benzyl-4-formylpiperidine in 100 ml of THF, followed by addition of a solution of 23.2 g of sodium methoxide (28% methanol solution) in 30 ml of THF under ice-cooling. After stirring for 2 hours as it was, the mixture was poured onto ice water, and the precipitated solid was collected by filtration and dried. The product was recrystallized from ethyl acetate-ethanol, to give 39.6 g (89%) of the title compound as white crystals., 22065-85-6

The synthetic route of 22065-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai Co., Ltd.; EP1468684; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22065-85-6,1-Benzylpiperidine-4-carbaldehyde,as a common compound, the synthetic route is as follows.

Example 1: Preparation of 2-[(E)-l-(l-benzyl-4-piperidyl)methylidene] -5,6-dimethoxy-l-indanone compound[62] 20 g of 5,6-dimethoxy-l-indanone and 23.27 g of l-benzyl-piperidine-4-carbaldehyde were added to 200 ml of tetrahydrofuran, and 6.75 g of sodium methoxide was added dropwise at 0 to 1O0C under nitrogen current. The resulting mixture was stirred at 0 to 1O0C for 15 minutes, and slowly warmed to a temperature of 20 to 250C and stirred for 3 hours. 160 ml of dichloromethane and 100 ml of purified water were added to the reaction mixture, and then adjusted to a pH range of 9.5 to 9.8 with 20% HCl. Then an organic phase was separated and distilled to remove a solvent. 60 ml of methanol was added to the residue, stirred at reflux for one hour, cooled to a temperature of 0 to 1O0C, and stirred for one hour. The resulting mixture was filtered, washed, and dried under a vacuum condition to obtain 36.53 g of a target compound (yield: 93.0%).[63] m.p. 175-1770C;[64] m/e 377.5 (parent ion);[65] 1U NMR (CDCl ) deltal.62~1.83 (m, 4H), 2.08-2.26 (m, 2H), 2.27-2.42 (m, IH),2.92-3.03 (m, 2H), 3.55-3.67 (m, 4H), 3.92 (s, 3H), 3.97 (s, 3H), 6.65 (d, IH), 6.89 (s, IH), 7.28 (s, IH), 7.30-7.39 (m, 5H) Example 2: Preparation of 2-[(E)-l-(l-benzyl-4-piperidyl)methylidene] -5,6-dimethoxy-l-indanone compound[68] 20 g of 5,6-dimethoxy-l-indanone and 23.27 g of l-benzyl-piperidine-4-carbaldehyde were added to 200 ml of tetrahydrofuran, and 8.50 g of sodium methoxide was added dropwise at 0 to 1O0C under nitrogen current. The resulting mixture was stirred at 0 to 1O0C for 15 minutes, and slowly warmed to a temperature of 20 to 250C and stirred for 3 hours. 160 ml of dichloromethane and 100 ml of purified water were added to the reaction mixture, and then adjusted to a pH range of 9.5 to 9.8 with 20% HCl. Then an organic phase was separated and distilled to remove a solvent. 60 ml of methanol was added to the residue, stirred at reflux for one hour, cooled to a temperature of 0 to 1O0C, and stirred for one hour. The resulting mixture was filtered, washed, and dried under a vacuum condition to obtain 33.86 g of a target compound (yield: 86.2%).

22065-85-6, 22065-85-6 1-Benzylpiperidine-4-carbaldehyde 89584, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; DONG WHA PHARM. IND. CO., LTD.; WO2008/126995; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem